Effect of Adrenergic Beta-Receptor Blocking Drugs on Blood Flow in the Coronary and Other Vascular Fields

Nayler, Winifred G.; McInnes, Iain B.; Swann, J. B.; Race, D.; Lowe, T. E.

doi:10.1093/cvr/2.4.371

Cited by 9 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reduction in coronary flow due to an increase in coronary resis tance, which has been reported earlier with the use of f3-blocking agents, has been confirmed recently in patients (158) and attributed to a reduction in oxygen consumption deriving from reduction in heart rate and myocar dial contractile force (134,138,180,181). Two-thirds of this effect is attrib uted to f3-blockade and one-third to direct action, since it is obtained follow ing pre-treatment with reserpine and is also produced by D-propranolol, which is almost devoid of any adrenergic f3-blocking action (182).…”

Section: The B-adrenergic Blocking Agentsmentioning

confidence: 53%

Cardiac Pharmacology

Méndez¹,

Kabela²

1970

Annu. Rev. Pharmacol.

View full text Add to dashboard Cite

Section: The B-adrenergic Blocking Agentsmentioning

confidence: 53%

Cardiac Pharmacology

Méndez¹,

Kabela²

1970

Annu. Rev. Pharmacol.

View full text Add to dashboard Cite

“…Propranolol is known to reduce stress-related augmentation of cardiac rate, contractility, and work-all of which have prominent oxygen-sparing effects (Dwyer et al, 1968;Wiener et al, 1969). Some have suggested that this agent also directly affects the coronary circulation and reduces myocardial flow (Parratt, 1965;Wolfson et al, 1966;Nayler et al, 1967Nayler et al, , 1968Stein et al, 1968;Marchetti et al, 1972) and oxygen consumption (Jorgensen et al, 1973;Mueller et al, 1974) while increasing coronary resistance. Since the Received for publication 22 November 1977 effect of propranolol on heart rate also uniformly decreases oxygen requirements, significant direct coronary actions may be obscured.…”

mentioning

confidence: 99%

Coronary and myocardial metabolic effects of combined glyceryl trinitrate and propranolol administration. Observations in patients with and without coronary disease.

Schang¹,

Pepine²

1978

Heart

View full text Add to dashboard Cite

SUMMARY Coronary haemodynamic and metabolic effects of propranolol and glyceryl trinitrate were studied in 12 patients with coronary artery disease and 5 without coronary heart disease, at rest and during tachycardia stress. Propranolol-associated reductions in indices of myocardial oxygen demand, left ventricle work, tension time, and left ventricle oxygen utilisation (LVV02) were reversed when heart rate was controlled by atrial pacing. Adding glyceryl trinitrate at rest also restored heart rate but decreased the left ventricular work index and tension time index as coronary resistance declined paradoxically. Tachycardia-related increases in tension time index and LVV02 were unchanged after propranolol, and ischaemia (angina, ST depression, and reduced lactate extraction) was not altered in most of the patients. During tachycardia, the addition of glyceryl trinitrate decreased the tension time index and LVV02; angina recurred in only 4 patients, and ST depression and lactate extraction improved. Similar haemodynamic changes occurred in the patients with normal coronary arteries.In contrast with propranolol administered alone, propranolol plus glyceryl trinitrate enhances tachycardia tolerance and prevents tachycardia-induced manifestations of ischaemia. This action is attributed to glyceryl trinitrate-associated improvement in the adequacy of myocardial perfusion.Although nitrates are frequently used in combination with propranolol and have been justified by clinical and haemodynamic rationale (Russek, 1968;Wiener et al., 1969;Aronow, 1972), there is no information on the effect of this combination on the coronary circulation. Propranolol is known to reduce stress-related augmentation of cardiac rate, con-

show abstract

Effects of Adrenergic Activators and Inhibitors on the Coronary Circulation

Parratt¹

1980

Adrenergic Activators and Inhibitors

View full text Add to dashboard Cite

Effect of Adrenergic Beta-Receptor Blocking Drugs on Blood Flow in the Coronary and Other Vascular Fields

Cited by 9 publications

References 0 publications

Cardiac Pharmacology

Cardiac Pharmacology

Coronary and myocardial metabolic effects of combined glyceryl trinitrate and propranolol administration. Observations in patients with and without coronary disease.

Effects of Adrenergic Activators and Inhibitors on the Coronary Circulation

Contact Info

Product

Resources

About