Effect of Adrenergic Activators and Inhibitors on the Electrical Activity of the Heart

Szekeres, L.; Papp, Julius Gy.

doi:10.1007/978-3-642-67505-8_17

Cited by 14 publications

(10 citation statements)

References 207 publications

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“…17 This decreases intercellular resistance 18 and increases the rate of rise of the zero phase of the action potential, 19 thereby increasing conduction velocity in the AV node, the atria, and the ventricles. 20 Repetition of the postablation pacing protocol under isoproterenol (1 to 3 g/min) infusion at the same or faster pacing cycle lengths as at baseline resulted in reversal of apparent BIC block in 7 (15.9%) of 44 patients. In 6 patients, there was evidence to suggest resumption of BIC.…”

Section: Discussionmentioning

confidence: 92%

Isoproterenol to Evaluate Resumption of Conduction After Right Atrial Isthmus Ablation in Type I Atrial Flutter

et al. 1999

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Background-After radiofrequency (RF) ablation of atrial flutter (AFL), the demonstration of bidirectional isthmus conduction (BIC) block is considered the hallmark of a successful procedure. The purpose of our study was to test the persistence of BIC block after isoproterenol administration and to evaluate the importance of this finding with regard to AFL recurrences. Methods and Results-RF ablation of AFL was performed in 44 consecutive patients with type I AFL by linear ablation of the posterior isthmus (nϭ29 patients), septal isthmus (nϭ4 patients), or both right atrial (RA) isthmi (nϭ11 patients).The procedural end point was complete BIC block and noninducibility of AFL. In case of noninducibility and apparent BIC block, the pacing protocol was repeated under isoproterenol infusion (1 to 3 g/min). Reversal of apparent BIC block occurred in 7 (15.9%) of 44 patients. Six patients had bidirectional and 1 had unidirectional resumption of isthmus conduction. Counterclockwise AFL could be reinduced in 4 of these patients. Two to 24 (median, 4) additional RF applications were required to achieve permanent BIC block. At a mean follow-up of 7.3Ϯ7.6 months (range, 2 to 31 months), 2 (4.5%) of 44 patients had AFL recurrences. Conclusions-Partial linear RF ablation could possibly aggravate preexisting nonuniform anisotropic conduction in the RA isthmus, resulting in profound conduction slowing and apparent BIC block. Isoproterenol can unmask apparent BIC block, thus providing an opportunity to assess the possibility of reversal of BIC block and completeness of isthmus ablation during the same procedure. The low incidence (4.5%) of AFL recurrences at follow-up suggests that noninducibility and BIC block under isoproterenol infusion may be a better end point for successful AFL ablation. (Circulation. 1999;99:3286-3291.)

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Section: Discussionmentioning

confidence: 92%

Isoproterenol to Evaluate Resumption of Conduction After Right Atrial Isthmus Ablation in Type I Atrial Flutter

et al. 1999

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“…The physiological relevance of cardiac a!adrenoreceptors mediating positive chronotropic responses is not clear, but some recent studies suggest that cardiac cy,-adrenoreceptors may be involved in disorders of cardiac rhythm (Sheridan et al, 1980). or-Adrenoreceptors in the central nervous system also appear to play some role and the influence of some psychotropic agents in CaC1,induced arrhythmias in the rat has been studied (Grimaldi, Maggi & Meli, 1981). However, it is not easy to dissociate actions at central and peripheral adrenoreceptors and the mechanism of the antiarrhythmic effects of wadrenoreceptor antagonists remains unclear (Szekeres & Papp, 1980).…”

Section: Discussionmentioning

confidence: 99%

In Vitro and in Vivo Antiarrhythmic Effects of Prazosin in the Rat

Miñano

Serrano

Durán

1984

Journal of Autonomic Pharmacology

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The possible antiarrhythmic action of prazosin was studied on two experimental models: a focus of ectopic automaticity in the rat isolated right ventricle and arrhythmias induced by i.v. CaCl2 in anaesthetized animals. In vitro, prazosin at 10(-5)M abolished the ectopic automaticity focus in 83% of cases (10/12). The effects of prazosin were not modified by reserpine pretreatment. In vivo, prazosin modified the range of CaCl2 arrhythmias, reduced the mean control sinus rate (by 21.7% at 1 mg/kg), reduced incidence and mortality by ventricular fibrillation and lengthened survival time of animals that eventually died. The results indicate that antagonism of postsynaptic alpha 1-adrenoreceptors may partly explain the efficacy of prazosin against some experimental cardiac arrhythmias.

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“…Logarithmic values (−log ED 50 ) are listed in Table 1 as AA observed activity. Each ED 50 (mg/kg) value was obtained from independent experiments in adrenaline included arrhythmia in anaesthetized rats (Szekeres and Papp, 1975). …”

Section: Methodsmentioning

confidence: 99%

QSAR studies on a number of pyrrolidin-2-one antiarrhythmic arylpiperazinyls

Nowaczyk

Kulig

2011

Med Chem Res

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The activity of a number of 1-[3-(4-arylpiperazin-1-yl)propyl]pyrrolidin-2-one antiarrhythmic (AA) agents was described using the quantitative structure–activity relationship model by applying it to 33 compounds. The molecular descriptors of the AA activity were obtained by quantum chemical calculations combined with molecular modeling calculations. The resulting model explains up to 91% of the variance and it was successfully validated by four tests (LOO, LMO, external test, and Y-scrambling test). Statistical analysis shows that the AA activity of the studied compounds depends mainly on the PCR and JGI4 descriptors.Electronic supplementary materialThe online version of this article (doi:10.1007/s00044-010-9540-x) contains supplementary material, which is available to authorized users.

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Effect of Adrenergic Activators and Inhibitors on the Electrical Activity of the Heart

Cited by 14 publications

References 207 publications

Isoproterenol to Evaluate Resumption of Conduction After Right Atrial Isthmus Ablation in Type I Atrial Flutter

Isoproterenol to Evaluate Resumption of Conduction After Right Atrial Isthmus Ablation in Type I Atrial Flutter

In Vitro and in Vivo Antiarrhythmic Effects of Prazosin in the Rat

QSAR studies on a number of pyrrolidin-2-one antiarrhythmic arylpiperazinyls

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