Effect of administration of nonsteroidal anti-inflammatory drugs before surgery on renal function in clinically normal dogs

Lobetti, Remo; Joubert, K.E.

doi:10.2460/ajvr.2000.61.1501

Cited by 62 publications

(39 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A previous study of ketoprofenassociated adverse renal effects found decreased endogenous creatinine clearance in dogs receiving ketoprofen before castration surgery [8]. Likewise, a separate study [22] reported decreased FC Na and urine specific gravity, and increased renal tubular epithelial cells in urine sediment after ovariohysterectomies in dogs receiving ketoprofen before surgery. Even short-term administration of ketoprofen may carry the risk of adverse renal effects under inhalation anesthesia.…”

Section: Discussionmentioning

confidence: 94%

Effects of Long-Term Oral Administration of Ketoprofen in Clinically Healthy Beagle Dogs

Narita

Tomizawa

Sato

et al. 2005

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. To investigate the adverse effects of long-term administration of ketoprofen in dogs, ketoprofen (1 mg/kg) was administered to five clinically healthy beagle dogs (ketoprofen group) and gelatin capsules (control group) were administered to four clinically healthy beagle dogs for 30 days. We monitored the dogs through periodic physical examination, blood analyses, endoscopic examinations, fecal occult blood tests, renal function tests, urinalysis, urinary enzyme indices and cuticle bleeding time analysis. The lesions in the stomach, especially in the pyloric antrum, and fecal occult blood progressively worsened in the ketoprofen group. However, the differences between the ketoprofen group and the control group were not statistically significant. One dog in the ketoprofen group temporarily exhibited a decrease in renal plasma flow and two dogs exhibited enzymuria. However, these changes did not persist and the other examinations showed no significant difference between premedication and postmedication in the ketoprofen group. Therefore, the adverse effects of long-term administration of ketoprofen observed in this study were not clinically important in healthy dogs. Nevertheless, further investigation of adverse renal effects from long-term administration of ketoprofen is necessary in the dogs with subclinical renal disease. KEY WORDS: adverse effect, canine, Ketoprofen, long-term administration.

show abstract

Section: Discussionmentioning

confidence: 94%

Effects of Long-Term Oral Administration of Ketoprofen in Clinically Healthy Beagle Dogs

Narita

Tomizawa

Sato

et al. 2005

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

show abstract

“…Opioid analgesics have traditionally been the most widely used analgesics in veterinary practice 31 . The classification of opioid analgesics as controlled drugs, concerns regarding their adverse effects and lack of familiarity with opioids available make veterinarians reluctant to use them for pre-emptive analgesia 6,23 . Moreover, opioids are known to cause cardiopulmonary depression and increase depth of sedation and thus prolong recovery, which can, depending on practice circumstances, be interpreted as undesirable effects of opioid use 20,27 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of morphine and carprofen administered alone or in combination for analgesia in dogs undergoing ovariohysterectomy

Dzikiti¹,

Joubert²,

Venter³

et al. 2006

J. S. Afr. Vet. Assoc.

View full text Add to dashboard Cite

In this study the analgesic efficacy of the pure agonistic opioid morphine and the cyclo-oxygenase type-2-selective carprofen were compared since there is no previous specific comparative study for these two common analgesics. Forty-five bitches undergoing elective ovariohysterectomy were randomly assigned to one of three groups; receiving morphine 0.4 mg/kg bodyweight pre-operatively and 0.2 mg/kg every 4-6 hours thereafter (Morphine group), receiving a once-off carprofen 4 mg/kg injection (Carprofen group) or receiving both morphine and carprofen (MorphCarp group). The dogs were premedicated with acepromazine 0.01 mg/kg and induced with either thiopentone 5-10 mg/kg or propofol 4-6 mg/kg. General anaesthesia was maintained with halothane in oxygen. The degree of pain was assessed over a 24-hour period under blinded conditions using a pain scale modified from the University of Melbourne pain scale and the Glasgow composite pain tool. Physiological parameters such as respiratory rate, pulse rate and body temperature were also assessed over the same time period. There was no significant difference in pain-scores and thus analgesia offered by the three analgesia protocols at any assessment point across the three groups, but there were differences within groups across time points. Baseline total pain-scores were lower than scores at all post-operative points within all three groups. Both morphine and carprofen provided good analgesia without any obvious adverse effects. This study indicates that at the dosages indicated above, carprofen administered on its own produces analgesia equal to that produced by morphine and that the two drugs administered together do not produce better analgesia than either drug administered on its own.

show abstract

“…Its increased activity in urine has been associated with proximal tubular damage in dogs (Heiene et al 1991). Excretion of urinary alkaline phosphatase is used to evaluate renal function in different conditions (Lobetti and Joubert 2000;Lobetti and Lambrechts 2000;Heiene et al 2001;Raekallio et al 2006). …”

Section: Alkaline Phosphatasementioning

confidence: 99%

Urinary biomarkers of renal function in dogs and cats: a review

Kovaříková¹

2015

Vet. Med.

View full text Add to dashboard Cite

Kidney diseases commonly affect dogs and cats. Early diagnosis of renal impairment may be challenging even when urinalysis is used to provide additional information. Serum creatinine concentration is often used in the diagnosis, but it is a relatively insensitive marker of renal function. Particular attention is aimed at the investigation of certain molecules that may occur in urine at elevated levels as a result of glomerular or tubular dysfunction. These changes may be found before the increase of serum creatinine levels. This review article summarises reports of urine biomarkers and their utility in detecting early kidney disease in dogs and cats. Detection of multiple urinary biomarkers in diagnosis of acute kidney injury and chronic kidney disease may increase specificity and sensitivity. Early diagnosis of reduced renal functional mass allows early therapeutic interventions which may decrease morbidity and mortality. Keywords: microalbuminuria; neutrophil gelatinase-associated lipocalin; N-acetyl-β-d-glucosaminidase; gammaglutamyl transpeptidase; immunoglobulin GAbbreviations AKI = acute kidney injury; ARF = acute renal failure; CKD = chronic kidney disease; CRP = C-reactive protein; GFR = glomerular filtration rate; GGT = gamma-glutamyl transpeptidase; HMW = high molecular weight; ICU = intensive care unit; IgG = immunoglobulin G; NAG = N-acetyl-β-d-glucosaminidase; NGAL = neutrophil gelatinaseassociated lipocalin; PTH = parathormone; RBP = retinol binding protein; UAC = urinary albumin to creatinine ratio; uGGT = urinary gamma-glutamyl transpeptidase; uNAG = urinary N-acetyl-β-d-glucosaminidase; UNCR = urinary neutrophil gelatinase-associated lipocalin to creatinine ratio; UPC = urinary protein to creatinine ratio; uRBP = urinary retinol binding protein; UTI = urinary tract infection

show abstract

Effect of administration of nonsteroidal anti-inflammatory drugs before surgery on renal function in clinically normal dogs

Abstract: In clinically normal dogs undergoing general anesthesia and elective surgery, the use of NSAID as analgesics is not contraindicated. Compared with ketorolac or ketoprofen, carprofen had the least effect on renal function and integrity.

Cited by 62 publications

References 23 publications

Effects of Long-Term Oral Administration of Ketoprofen in Clinically Healthy Beagle Dogs

Effects of Long-Term Oral Administration of Ketoprofen in Clinically Healthy Beagle Dogs

Comparison of morphine and carprofen administered alone or in combination for analgesia in dogs undergoing ovariohysterectomy

Urinary biomarkers of renal function in dogs and cats: a review

Contact Info

Product

Resources

About