Effect of adenomyosis on adverse obstetrical outcomes in twin pregnancies achieved with assisted reproductive technology

Kim, Mi Sun; Jang, Ji Hyon; Park, Seulgee; Ahn, Eun Hee; Jung, Sang Hee

doi:10.1080/01443615.2020.1867969

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…Restricting the analysis to twin gestations, we registered a higher frequency of intrauterine fetal demise among patients with adenomyosis, confirming a recent report by Kim et al [ 42 ].…”

Section: Discussionsupporting

confidence: 90%

The Prevalence and Clinical Impact of Adenomyosis in Pregnancy-Related Hysterectomy

Orsi

Somigliana

Cribiù

et al. 2022

JCM

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Background: The epidemiology of adenomyosis has been traditionally based on patients undergoing hysterectomy for gynecological indications, while its prevalence among hysterectomies performed for obstetric complications is unknown. The aim of this study was to assess the prevalence and clinical impact of adenomyosis diagnosed through histology among women undergoing pregnancy-related hysterectomy (PH). Methods: This was a retrospective cohort study. Women who delivered at a tertiary care regional obstetric hub in Milan between 2009 and 2020 were reviewed to identify cases of PH. Histopathological reports of surgical specimens were examined. Cases with adenomyosis were compared to those without adenomyosis for baseline characteristics, obstetric history and outcomes. Results: During the study period there were 71,061 births and a total of 130 PH, giving a PH incidence of 1.83 per 1000 deliveries. Adenomyosis cases were 18, giving a prevalence of 13.8%. Adenomyosis was associated with placenta previa (77.8 vs. 45.5%, p = 0.01), chorionamnionitis (27.8 vs. 5.4%, p = 0.008), lower gestational age at birth (32 ± 4.6 vs. 35.5 ± 3.6 weeks’ gestation, p = 0.0004), and intrauterine fetal demise among twin pregnancies (50 vs. 4.5%, p = 0.048). Conclusion: Adenomyosis entails a relevant impact on obstetric and perinatal outcomes related to PH. More evidence is needed on the clinical relevance of an ultrasonographic diagnosis of adenomyosis before conception.

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“…Restricting the analysis to twin gestations, we registered a higher frequency of intrauterine fetal demise among patients with adenomyosis, confirming a recent report by Kim et al [ 42 ].…”

Section: Discussionsupporting

confidence: 90%

The Prevalence and Clinical Impact of Adenomyosis in Pregnancy-Related Hysterectomy

Orsi

Somigliana

Cribiù

et al. 2022

JCM

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“…Meanwhile we have collected the clinicopathological data of pregnant women with adenomyosis who received treatment in the Women and Children's Hospital of Chongqing Medical University during the same period as the validation cohort. The inclusion criteria were as follows: (1) Patients with de nitive diagnosis of adenomyosis; (2) This pregnancy was a singleton pregnancy with a de nite pregnancy outcome; (3) Patients have conceived naturally or through ART, and B-ultrasound found embryo and primitive cardiac tube beat in the uterus during early pregnancy. The exclusion criteria were as follows:(1) Patients with assisted reproductive implantation failure, biochemical pregnancy, and ectopic pregnancy; (2) Patients with other diseases (including uterine malformations, chromosomal abnormalities, chronic hypertension, diabetes, nephropathy, thyroid disease and other basic medical diseases, immune system diseases, diseases of the blood system etc.)…”

Section: Study Populationmentioning

confidence: 99%

“…[1] Therefore, most of these women must use assisted reproduction technology (ART) to get pregnant. [2,3] However, even with the help of ART, many women are also unable to get the desired fertility outcomes, conversely, adverse pregnancy outcomes such as miscarriage, premature delivery, and SGA often occur. [4,5] Currently, there are few studies about the effect of adenomyosis (AD) on adverse pregnancy outcomes.…”

Section: Introductionmentioning

confidence: 99%

Establishment and validation of a nomogram model for predicting adverse pregnancy outcomes of pregnant women with adenomyosis

Kong²,

Jiang³

et al. 2022

Preprint

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Purpose To establish a reliable nomogram model to predict the risk of major adverse pregnancy outcomes in pregnant women with adenomyosis, and to provide a reference tool for the hierarchical management and the prenatal examination of pregnant women. Methods We collected the clinical data of pregnant women with adenomyosis who were treated in the First Affiliated Hospital of Chongqing Medical University and the Women and Children’s Hospital of Chongqing Medical University from January 2014 to June 2020. They were divided into the training cohort and the validation cohort, respectively. In the training cohort, we screened out risk factors associated with major adverse pregnancy outcomes and established a model, which was subsequently validated. Results In the training cohort, we found that natural conception or not, type of adenomyosis, previous parity, history of infertility or adverse pregnancy outcomes, history of uterine body surgerywere associated with major adverse pregnancy outcomes of pregnant women with adenomyosis, and based on these factors, a nomogram model was constructed. The calibration curves of the model were well fitted in both the training and validation cohorts. The receiver operating characteristic curve (ROC curve) showed that the area under the curve (AUC) was 0.862 and 0.836 in the training and validation cohorts, respectively. The optimal risk threshold of the model was 0.24, and this threshold can be applied to risk stratification of pregnant women. Conclusion The nomogram model established in this study can reliably predict the risk of major APO in pregnant women with AD.

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“…For patients who have no symp-Am J Transl Res 2024; 16(2):584-591 toms and no fertility requirements, expectant observational treatment can be performed. Patients with mild symptoms, fertility requirements, and near-menopausal patients can try drug treatment (hormone therapy is the most common drug therapy), but there are potential adverse drug reactions and risk of reoccurrence after drug withdrawal [4]. Patients with severe symptoms and ineffective medical treatment can be treated with surgery.…”

Section: Introductionmentioning

confidence: 99%

Effects of Shixiao Huoxue Decoction on pain, tumor necrosis factor-α, and interleukin-8 in patients with adenomyosis

2024

Am J Transl Res

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Objective: To explore the effect of Shixiao Huoxue Decoction on pain and tumor necrosis factor (TNF)-α and interleukin (IL)-8 levels in patients with adenomyosis. Methods: A total of 65 patients with adenomyosis admitted to South District of Guang'anmen Hospital from January 2020 to December 2021 were divided into two groups according to the treatment methods. The control group was treated with pregnatrienone, and the study group was treated with additional Shixiaohuoxue decoction. The incidence of complications, treatment efficacy, levels of inflammatory factors, Traditional Chinese Medicine symptom score, dysmenorrhea score, menstrual volume score, dysmenorrhea symptom score, changes in uterine volume, level of insulin-like growth factor 1 (IGF-1), and changes in the level of carbohydrate antigen (CA125) were observed before and after treatment in both two groups. Univariate Logistic analysis showed that uterine volume, IGF-1, CA125, serum IL-8 and TNF-α were correlated with the short-term efficacy of Meixiaohuoxue Decoction in the treatment of uterine adenomyosis (P<0.05). Results: The levels of IL-8 and TNF-α in the study group were significantly lower than those in the control group after treatment (P<0.05). The scores of dyspareunia and non-menstrual pelvic pain in the study group were significantly lower than those in the control group (P<0.05). The overall response rate in the study group (93.75%) was significantly higher than that in the control group (66.66%) (P<0.05). The scores of Traditional Chinese Medicine symptoms, dysmenorrhea, menstrual volume, and dysmenorrhea symptoms in the study group were significantly lower than those in the control group after treatment (P<0.05). The IGF-1 and CA125 levels in the study group were significantly lower than those in the control group after treatment (P<0.05). However, no significant difference in uterine volume was found between the two groups after treatment (P>0.05). Conclusion: Xiaoxiao Huoxue Decoction demonstrated a better treatment efficacy in patients with adenomyosis through improving dysmenorrhea and Traditional Chinese Medicine symptoms, as well as reducing the levels of body inflammatory factors, non-menstrual pelvic pain, and dyspareunia, thus contributing to early recovery of patients. Therefore, Xiaoxiao Huoxue Decoction is worthy of promotion in clinical treatment of adenomyosis.

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Effect of adenomyosis on adverse obstetrical outcomes in twin pregnancies achieved with assisted reproductive technology

Cited by 4 publications

References 21 publications

The Prevalence and Clinical Impact of Adenomyosis in Pregnancy-Related Hysterectomy

The Prevalence and Clinical Impact of Adenomyosis in Pregnancy-Related Hysterectomy

Establishment and validation of a nomogram model for predicting adverse pregnancy outcomes of pregnant women with adenomyosis

Effects of Shixiao Huoxue Decoction on pain, tumor necrosis factor-α, and interleukin-8 in patients with adenomyosis

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