1973
DOI: 10.1093/infdis/128.5.658
|View full text |Cite
|
Sign up to set email alerts
|

Effect of Adenine Arabinoside on Severe Herpesvirus hominis Infections in Man

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
8
0

Year Published

1974
1974
2006
2006

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 96 publications
(8 citation statements)
references
References 16 publications
0
8
0
Order By: Relevance
“…A wide range of agents and procedures which are able to inhibit or suppress HSV replication in vivo or in vitro with varying degrees of success have emerged (with others being added to the list continually). Noteworthy among these are: several antimitotic chemicals (253), cancer cell extracts (2), human gamma globulin (1), trifluorothymidine (261), trifluorodeoxyuridine (124), lysine (123), iododeoxycytidine (144), iododeoxyuridine (IudR or IDU; 56, 138, 261), polyinosinic-cytidylic acid (179,231,260), interferon (126), ara-c (109), ara-c with L-asparaginase (34), arabinofuranosyladenine (138,200), phosphonoacetic acid (238), adenine arabinoside (45,199), rifamycin (181), ethyl ether (186), various photodynamic dyes (1C4), X irradiation (7,139), a vaccinia virus vaccine (72), a herpesvirus vaccine (127, 251), cryotherapy (19,83,104), and psychotherapy (25). However, HSV has proven to be resistant to glutathione (124), fl-methazone (124), pyran copolymers (231), lysozyme (124), 6-azauridine (138), and kethoxal (256).…”
Section: Treatment Of Recurrent Hsvmentioning
confidence: 99%
“…A wide range of agents and procedures which are able to inhibit or suppress HSV replication in vivo or in vitro with varying degrees of success have emerged (with others being added to the list continually). Noteworthy among these are: several antimitotic chemicals (253), cancer cell extracts (2), human gamma globulin (1), trifluorothymidine (261), trifluorodeoxyuridine (124), lysine (123), iododeoxycytidine (144), iododeoxyuridine (IudR or IDU; 56, 138, 261), polyinosinic-cytidylic acid (179,231,260), interferon (126), ara-c (109), ara-c with L-asparaginase (34), arabinofuranosyladenine (138,200), phosphonoacetic acid (238), adenine arabinoside (45,199), rifamycin (181), ethyl ether (186), various photodynamic dyes (1C4), X irradiation (7,139), a vaccinia virus vaccine (72), a herpesvirus vaccine (127, 251), cryotherapy (19,83,104), and psychotherapy (25). However, HSV has proven to be resistant to glutathione (124), fl-methazone (124), pyran copolymers (231), lysozyme (124), 6-azauridine (138), and kethoxal (256).…”
Section: Treatment Of Recurrent Hsvmentioning
confidence: 99%
“…Of them, 5-iodo-2'-deoxyuridine and 1-fl-D-arabinofuranosylcytosine (cytosine arabinoside) have been administered systemically to treat human infections of serious life-threatening character (2, 8). In the past 3 years, 9-fl-D-arabinofuranosyladenine (adenine arabinoside, ara-A) also has been used in clinical trials against serious or life-threatening human HVH infections; this purine nucleoside has proved to be much less toxic than cytosine arabinoside or 5-iodo-2'-deoxyuridine (1,2). In fact, evidence of any severe immediate side effects has not been documented at doses of 10 to 20 mg per kg per day during or after 14-to 20-day treatment courses (1, 2).…”
mentioning
confidence: 99%
“…In fact, evidence of any severe immediate side effects has not been documented at doses of 10 to 20 mg per kg per day during or after 14-to 20-day treatment courses (1, 2). At these doses, there has been some evidence of clinical and virological response based upon studies in patients with both HVH and varicella-zoster infections (1,2).…”
mentioning
confidence: 99%
“…Trials with cytosine arabinoside in zoster and iododeoxyuridine in herpes encephalitis have indicated the inadequacy of these drugs (Boston Interhospital Group, 1975;Stevens et al, 1973). At the present time, adenosine arabinoside is undergoing clinical trials and shows some promise (Ch'ien et al, 1973;Whitley, 1976). mised patients, evaluation of antiviral agents is particularly important.…”
Section: Discussionmentioning
confidence: 99%