Effect of acute swimming exercise at different intensities but equal total load over metabolic and molecular responses in swimming rats

Forte, Lucas Dantas Maia; Rodrigues, Natália de Almeida; Cordeiro, André V.; Fante, Thaís de; Simino, Laís Angélica de Paula; Torsoni, Adriana; Torsoni, Márcio Alberto; Gobatto, Cláudio Alexandre; Manchado-Gobatto, Fúlvia de Barros

doi:10.1007/s10974-022-09614-4

Cited by 5 publications

(4 citation statements)

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“…No studies investigating the effect of low/moderate intensity on mRNA in humans were included in the present review. In rodents, the use of low/moderate intensity has been more common than high‐intensity exercise, observing an increase in SLC16A1 mRNA at some point in most cases, 18,30–33 except one study 34 . Of the nine exercise sessions (applied by the six studies), five of them produced increases in SLC16A1 mRNA, and four produced increases in SLC16A3 .…”

Section: Resultsmentioning

confidence: 99%

“…Although based on scarce studies, single‐session interventions with high‐intensity do not appear to be sufficient stimulus to generate changes in mRNA for any of the muscle SLC16A1 or SLC16A3 in male humans (no human study utilize low‐/moderate‐intensity exercise) 16,17 . On the contrary, the four interventions in rodents with single‐session interventions show increases at some point both in SLC16A1 18,30–32 and SLC16A3 mRNA 18,30,31 . The discrepancies between humans and animals could be due to several reasons, like the training status of the sample (training status is not usually evaluated in rodents) or the setting of the exercise intensity (relative intensity in humans vs. absolute intensity in rodents).…”

Section: Discussionmentioning

confidence: 99%

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Exercise influence on monocarboxylate transporter 1 (MCT1) and 4 (MCT4) in the skeletal muscle: A systematic review

Benítez‐Muñoz,

Cupeiro,

Rubio‐Arias

et al. 2024

Acta Physiologica

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This review aims to systematically analyze the effect of exercise on muscle MCT protein levels and mRNA expression of their respective genes, considering exercise intensity, and duration (single‐exercise session and training program) in humans and rodents, to observe whether both models offer aligned results. The review also aims to report methodological aspects that need to be improved in future studies. A systematic search was conducted in the PubMed and Web of Science databases, and the Preferred Reporting Items for Systematic review and Meta‐Analyses (PRISMA) checklist was followed. After applying inclusion and exclusion criteria, 41 studies were included and evaluated using the Cochrane collaboration tool for risk of bias assessment. The main findings indicate that exercise is a powerful stimulus to increase MCT1 protein content in human muscle. MCT4 protein level increases can also be observed after a training program, although its responsiveness is lower compared to MCT1. Both transporters seem to change independently of exercise intensity, but the responses that occur with each intensity and each duration need to be better defined. The effect of exercise on muscle mRNA results is less defined, and more research is needed especially in humans. Moreover, results in rodents only agree with human results on the effect of a training program on MCT1 protein levels, indicating increases in both. Finally, we addressed important and feasible methodological aspects to improve the design of future studies.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Exercise influence on monocarboxylate transporter 1 (MCT1) and 4 (MCT4) in the skeletal muscle: A systematic review

Benítez‐Muñoz,

Cupeiro,

Rubio‐Arias

et al. 2024

Acta Physiologica

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“…Although experiments with rodents submitted to physical training allow a refined control of factorial variables, individualized prescription and load monitoring are recurrently overlooked. This perspective enables deep interpretations of the physical training on stress biomarkers ( de Araujo et al, 2012 ) and molecular adaptations ( Rodrigues et al, 2021 ; Forte et al, 2022 ). Previous studies have submitted BALB/c (Nu/Nu) mice to physical training lasting 8 ( Jones et al, 2005 ; Hagar et al, 2019 ) or 12 weeks ( Lee et al, 2017 ; Lee et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Validity of the peak velocity to detect physical training improvements in athymic mice

et al. 2022

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This study comprises two complementary experiments with athymic Balb/c (Nu/Nu) mice. In experiment 1, the aim was to verify the reproducibility of the peak velocity (VPeak) determined from the incremental test. The second experiment aimed to assess the VPeak sensitivity to prescribe and detect modulations of the physical training in athymic nude mice. Sixteen mice were submitted to two incremental treadmill tests separated by 48-h (Experiment 1). The test consisted of an initial warm-up of 5 minutes. Subsequently, animals initiated the tests at 8 m min−1 with increments of 2 m min−1 every 3 minutes. The VPeak was determined as the highest velocity attained during the protocol. In experiment 2, these animals were randomly allocated to an exercise group (EG) or a control group (CG). The training protocol consisted of 30-min of treadmill running at 70% of the VPeak five times a week for 4 weeks. High indexes of reproducibility were obtained for VPeak (Test = 19.7 ± 3.6 m min−1; Retest = 19.2 ± 3.4 m min−1; p = 0.171; effect size = 0.142; r = 0.90). Animals from the EG had a significant increase of VPeak (Before = 18.4 ± 2.7 m min−1; After = 24.2 ± 6.0 m min−1; p = 0.023). Conversely, a significant decrease was observed for the CG (Before = 21.1 ± 3.9 m min−1; After = 15.9 ± 2.7 m min−1; p = 0.038). The VPeak is a valid parameter for exercise prescription in studies involving athymic nude mice.

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“…Many patients will complain of peripheral pulmonary respiratory embolism. Many aerobic swimming exercise findings of heart failure are related to the neurohormonal changes that help compensate for the reduced cardiac output and acute pulmonary respiratory embolism [31]. An increased CRF may be present as a result of decreased sympathetic tone.…”

Section: Cardiorespiratory Fitness (Crf)mentioning

confidence: 99%

Swimming Exercise-Induced Improvements in Cardiorespiratory Fitness (CRF) are Caused by Nitric Oxide Functional Adaptations in the Oxygen Transport System

Wu¹

2023

Cardiorespiratory Fitness - New Topics

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Cardiorespiratory fitness (CRF) is associated with referring to enhance oxygen transport capacity to respiratory systems and increasing oxygen transport circulatory to skeletal muscle to produce energy. The aim of this report on the health-related CRF in the oxygen transport system-mediated physiological nitric oxide (NO) functional adaptations. Therefore, we want to know that swimming exercise-induced improvements in CRF resulted in increased oxygen transport capacity during physical activity of the respiratory systems. Therefore, the oxygen circulatory transport system is related to NO signaling and has been associated with various pathophysiologic functions and neuronal activity. Besides mediating normal functions, NO is implicated in inflammation and hypertension disease states. Swimming exercise is a good way to increase the rate of metabolism. Swimming exercise improves heart rate and oxygen circulatory, and increases the rate of metabolism and burning of heat. In this context, this review summarizes the roles of NO in improvements in cardiorespiratory fitness.

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Effect of acute swimming exercise at different intensities but equal total load over metabolic and molecular responses in swimming rats

Cited by 5 publications

References 53 publications

Exercise influence on monocarboxylate transporter 1 (MCT1) and 4 (MCT4) in the skeletal muscle: A systematic review

Exercise influence on monocarboxylate transporter 1 (MCT1) and 4 (MCT4) in the skeletal muscle: A systematic review

Validity of the peak velocity to detect physical training improvements in athymic mice

Swimming Exercise-Induced Improvements in Cardiorespiratory Fitness (CRF) are Caused by Nitric Oxide Functional Adaptations in the Oxygen Transport System

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