Effect of acute stress on sexual behavior in female rats: Participation of the central angiotensinergic system

Cecconello, Ana Lúcia; Raineki, Charlis; Sebben, Vanise; Lucion, Aldo Bolten; Sanvitto, Gilberto Luiz

doi:10.1016/j.bbr.2009.10.026

Cited by 13 publications

(11 citation statements)

References 60 publications

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“…Although the RAS is known to influence the function of amygdalar neurons (Breigeiron et al 2002; Cecconello et al 2010; Heshmatian et al 2007; Llano Lopez et al 2012; von Bohlen und Halbach et al 2001) the contribution of AT2R to these effects is not clear. Activation of the RAS within the amygdala, has been found to impact blood pressure (Heshmatian et al 2007), hydromineral balance (Sakai et al 2000; Yan et al 2014), and sexual behavior (MeA) (Breigeiron et al 2002; Cecconello et al 2010). Pharmacological inhibition of amygdalar AT1R via bilateral infusion of losartan is anxiolytic in acutely stressed rats when tested in the elevated plus maze (Llano Lopez et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system

et al. 2014

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Angiotensin-II acts at its type-1 receptor (AT1R) in the brain to regulate body fluid homeostasis, sympathetic outflow and blood pressure. However, the role of the angiotensin type-2 receptor (AT2R) in the neural control of these processes has received far less attention, largely because of limited ability to effectively localize these receptors at a cellular level in the brain. The present studies combine the use of a bacterial artificial chromosome transgenic AT2R-enhanced green fluorescent protein (eGFP) reporter mouse with recent advances in in situ hybridization (ISH) to circumvent this obstacle. Dual immunohistochemistry (IHC)/ ISH studies conducted in AT2R-eGFP reporter mice found that eGFP and AT2R mRNA were highly co-localized within the brain. Qualitative analysis of eGFP immunoreactivity in the brain then revealed localization to neurons within nuclei that regulate blood pressure, metabolism and fluid balance (e.g., NTS and median preoptic nucleus [MnPO]), as well as limbic and cortical areas known to impact stress responding and mood. Subsequently, dual IHC/ISH studies uncovered the phenotype of specific populations of AT2R-eGFP cells. For example, within the NTS, AT2R-eGFP neurons primarily express glutamic acid decarboxylase-1 (80.3 ± 2.8 %), while a smaller subset express vesicular glutamate transporter-2 (18.2 ± 2.9 %) or AT1R (8.7 ± 1.0 %). No co-localization was observed with tyrosine hydroxylase in the NTS. Although AT2R-eGFP neurons were not observed within the paraventricular nucleus of the hypothalamus (PVN), eGFP- immunoreactivity is localized to efferents terminating in the PVN and within GABAergic neurons surrounding this nucleus. These studies demonstrate that central AT2R are positioned to regulate blood pressure, metabolism and stress responses.

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Section: Discussionmentioning

confidence: 99%

Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system

et al. 2014

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“…Microinjection of Ang II in the amygdala of the rat increases the discharge rate of amygdalar neurons and the increase can be blocked by AT 1 receptor antagonists [28]. Although studies of the specific role of Ang II in the amygdala are limited, it has been shown that Ang II microinjection into the CeA reduced sexual behaviour [29] and the blockade of AT 1 or AT 2 receptors in the CeA prevented the effect of stress and the effect of Ang II microinjection into this nucleus on sexual receptivity [30]. Moreover, the CeA has been implicated in anxiety, meanwhile, the basolateral amygdala in the stress response and memory [16].…”

Section: Discussionmentioning

confidence: 99%

Fear-Potentiated Behaviour Is Modulated by Central Amygdala Angiotensin IIAT1Receptors Stimulation

Marinzalda

Pérez

Gargiulo

et al. 2014

BioMed Research International

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Central nucleus of the amygdala (CeA) is one of the most important regulatory centres for the emotional processes. Among the different neurotransmitter systems present in this nucleus, AT1 receptors have been also found, but their role in the generation and modulation of emotions is not fully understood. The present work evaluated the effect of intra-amygdalar injection of losartan (AT1 receptor antagonist) and angiotensin II (Ang II) in the anxiety state induced by fear-potentiated plus maze in male Wistar rats. Fear in the elevated plus maze can be potentiated by prior inescapable footshock stress. The decrease in the time spent in the open arms induced by the inescapable footshock was totally prevented by losartan (4 pmol) administration in CeA. It was also found that Ang II (48 fmol) administration decreased the time spent in the open arms in animals with or without previous footshock exposure. The locomotor activity and grooming behaviour were also evaluated. The results obtained from the different parameters analyzed allowed us to conclude that the Ang II AT1 receptors in CeA are involved in the anxiety state induced by stress in the fear-potentiated plus-maze behaviour.

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“…Nevertheless, effects of Ang II on sexual behavior are still controversial. Blockade of both Ang II receptor subtypes in the medial amygdala does not alter sexual behavior in female rats [31]. The Ang II receptor blockers in hypertension also do not show any alterations of sexual behavior in male rats [56].…”

Section: Effect Of Losartan On Reproductive Parametersmentioning

confidence: 94%

“…Ovulation and oocyte maturation seem to be stimulated by Ang II produced in ovaries [27]. Our research group has demonstrated the involvement of Ang II on stress-induced secretions of prolactin in lactating and non-lactating female rats [28][29][30] and on sexual behavior in female [31] and male rats [32].…”

Section: Introductionmentioning

confidence: 95%

Prevention of metabolic disorders and reproductive performance deficits by the blockade of Angiotensin II AT1 receptor in female rats fed with cafeteria diet

Sagae

Lubaczeuski

Zacharias

et al. 2013

Physiology & Behavior

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Effect of acute stress on sexual behavior in female rats: Participation of the central angiotensinergic system

Cited by 13 publications

References 60 publications

Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system

Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system

Fear-Potentiated Behaviour Is Modulated by Central Amygdala Angiotensin IIAT1Receptors Stimulation

Prevention of metabolic disorders and reproductive performance deficits by the blockade of Angiotensin II AT1 receptor in female rats fed with cafeteria diet

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