Effect of acute respiratory acidosis on mesenteric circulation of dogs

Dp, Tashkin; Goldstein, PJ; Simmons, D H

doi:10.1152/ajplegacy.1969.217.6.1549

Cited by 17 publications

(6 citation statements)

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“…The increase in liver flow with carbon dioxide seen in this study confirms previous results (Tashkin, Goldstein and Simmons, 1969;Scholtholt and Shiraishi, 1970) obtained with e.m.f. probes.…”

Section: Discussionsupporting

confidence: 93%

Effect of Hypercarbia on Hepatic Blood Flow and Oxygen Consumption in the Greyhound

Hughes

Mathie

Campbell

et al. 1979

British Journal of Anaesthesia

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The stability of a technique for measuring hepatic blood flow and oxygen consumption was established in six greyhounds anaesthetized with pentobarbitone (group A). Subsequently, the effects of increased PaCO2 were studied in another six animals (group B). With one exception (splenic blood flow) no significant changes were observed in any of the indices measured in group A. In group B, although hepatic arterial blood flow (HABF) decreased when PaCO2 increased, both portal venous blood flow (PVBF) and total liver blood flow (HABF+PVBF) increased. However, these changes were much less marked after 20 min. Hepatic oxygen consumption and splenic venous blood flow were unchanged with an increase in PaCO2.

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Section: Discussionsupporting

confidence: 93%

Effect of Hypercarbia on Hepatic Blood Flow and Oxygen Consumption in the Greyhound

Hughes

Mathie

Campbell

et al. 1979

British Journal of Anaesthesia

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“…Hypercapnia may have a direct vasodilatory effect and indirect sympathetically mediated vasoconstrictor effect on gut blood vessels (45,46). In our model, we cannot distinguish between these two effects and the effect of increased pressure.…”

Section: Discussionmentioning

confidence: 89%

Gastrointestinal microcirculation and cardiopulmonary function during experimentally increased intra-abdominal pressure*

Olofsson

Berg

Ahn

et al. 2009

Critical Care Medicine

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Our animal model of low and high IAP by intraperitoneal CO2-insufflation worked well for studies of microcirculation, hemodynamics, and pulmonary function. During stepwise increases of pressure there were marked effects on global hemodynamics, respiratory function, and microcirculation. The results indicate that intestinal mucosal flow, especially small bowel mucosal flow, although reduced, seems better preserved in response to intra-abdominal hypertension caused by CO2-insufflation than other intra-abdominal microvascular beds.

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“…The local addition of either acid or CO 2 to portal venous blood increases portal resistance and reduces portal flow whereas slight changes in the opposite direction are noted in the hepatic arterial circulation, with an overall reduction of total hepatic blood flow (133). On the other hand, systemicacute hypercapnia (PaC0 2 60 to 100 mm Hg) has been observed to increase mesenteric, portal, and total hepatic blood flow in anesthetized dogs (134)(135)(136); the enhancement of mesenteric flow has recently been confirmed in the sheep (137). A note of caution is in order because these results were all obtained by mounting flow probes around relevant arteries, thus potentially interfering with vessel innervation.…”

Section: Hepatic Intestinal and Renal Circulationmentioning

confidence: 99%