Effect of Acute Renal Failure upon Cell Division in the Jejunum

McDermott, Francis T.; Nayman, Jack; Boer, W.G.R.M. de

doi:10.1097/00000658-197108000-00014

Cited by 18 publications

(7 citation statements)

References 5 publications

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“…The normal appearance of the small intestine by light microscopy is in agreement with earlier studies [7][8][9][10]. The shortening of the microvilli in the uremic rats found in the electron microscopic examina tion could be explained by an inhibition of cell division and differentiation as demonstrated in previous studies [7][8][9][10]. In a recent study a reduced thickening of the glycocalyx was seen [20].…”

Section: Discussionsupporting

confidence: 90%

“…Previous studies have shown lesions, such as inflammation and ulceration in the ce cum, but not in other parts of the intestine after bilateral nephrectomy [6,11]. The normal appearance of the small intestine by light microscopy is in agreement with earlier studies [7][8][9][10]. The shortening of the microvilli in the uremic rats found in the electron microscopic examina tion could be explained by an inhibition of cell division and differentiation as demonstrated in previous studies [7][8][9][10].…”

Section: Discussionsupporting

confidence: 89%

“…These changes might have effects on enterocyte growth and differentiation including changes in the expression of brush border enzymes. In fact inhibition of cell divi sion and proliferation has been demonstrated in acute uremic mice [7][8][9][10]. This might allow accumulation of certain enzymes (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…Intestinal lesions such as submucosal inflammation, edema, focal ulcerations and necrosis have been demon strated in the cecum after bilateral nephrectomy in rats [6]. In acute uremia, previous investigations have not demonstrated morphological lesions, but displayed an inhibition of cell division and proliferation in the esopha gus, jejunum and ileum in mice subjected to urinary outflow obstruction and/or uranyl nitrate nephrotoxicity [7][8][9][10][11]. A decreased activity of alkaline phosphatase, a jejunal brush border enzyme, has been demonstrated by histoenzymatic methods in acutely uremic rats probably due to decreased cell differentiation [11].…”

Section: Introductionmentioning

confidence: 99%

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Small Intestinal Peptidases and Disaccharidases in Rats with Acute Uremia

Magnusson

Sjöström²,

Norén³

et al. 1991

Nephron

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Acute uremia was induced in rats with temporary clamping of the left renal pedicle and contralateral nephrectomy. Jejunal peptidase activities (aminopeptidase N, dipeptidyl peptidase IV and aminopeptidase A), disaccharidase activities (maltase, sucrase, lactase and trehalase) and morphology were studied. A significant (p < 0.05) increase in aminopeptidase N activity and a positive correlation between aminopeptidase N activity and serum urea was found in the uremic rats. The other peptidase activities showed a slight increase in the uremic rats. A shortening of the microvilli of the small intestinal epithelial cells in the uremic rats was seen by electron microscopy. The disaccharidase activities were unaltered. This study shows the presence of functional alterations in the small intestine in rats with acute uremia. The observations are also compatible with different regulation mechanisms for the brush border peptidases and disaccharidases.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Small Intestinal Peptidases and Disaccharidases in Rats with Acute Uremia

Magnusson

Sjöström²,

Norén³

et al. 1991

Nephron

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“…In this context, it is of interest to note that uremic man has an increased number of mitoses in the crypts [I], whereas the contrary is true in the uremic mouse [2,17]. An explanation for these discre pancies between man and animal, besides species differ ences, might be a different intake of energy and nutrients, e.g., protein.…”

Section: Resultsmentioning

confidence: 99%

Small Intestinal Dipeptidases and Disaccharidases in Experimental Uremia in Rats

Sterner¹,

Asp²,

Dahlqvist³

et al. 1980

Nephron

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Rats were made severely uremic with partial nephrectomy (24-hour creatinine clearance 10% of normal). Jejunal dipeptidase activities (substrates: glycyl-L-leucine, L-alanyl-L-proline, and L-methionyl-L-methionine), disaccharidase activities (maltase, sucrase, trehalase, and lactase) and morphology were studied. A highly significant increase in glycyl-L-leucine and L-methionyl-L-methionine dipeptidases was found in uremic rats compared with controls. Proline dipeptidase activities were unaltered. Disaccharidase activities showed a slight increase in sucrase in uremic rats; otherwise no change was found.

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