Effect of acute peppermint oil administration on gastric sensorimotor function and nutrient tolerance in health

Papathanasopoulos, Athanasios; Rotondo, Alessandra; Janssen, Pieter; Boesmans, Werend; Farré, Ricard; Berghe, Pieter Vanden; Tack, Jan

doi:10.1111/nmo.12102

Cited by 49 publications

(52 citation statements)

References 41 publications

(96 reference statements)

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“…These observations confirm that duodenal nutrients can induce or enhance gastric relaxation, but do not reveal how much this contributes to the GA reflex under physiological circumstances. In the present study, we used IGP to quantify changes in gastric tone, and similar to previous studies, we observed a pressure drop upon intragastric nutrient infusion, representing gastric relaxation. When the passage of nutrients to the duodenum was blocked by a pyloric balloon, the magnitude of the IGP drop was significantly inhibited.…”

Section: Discussionsupporting

confidence: 75%

Duodenal nutrient exposure contributes to enhancing gastric accommodation

Carbone

Verschueren

Rotondo

et al. 2019

Neurogastroenterology Motil

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Background The gastric accommodation reflex consists of a relaxation which creates a reservoir for the ingested food before emptying to the duodenum occurs. The mechanisms that control gastric accommodation are not fully understood. This study aims to use intragastric pressure (IGP) measurement and pyloric balloon obstruction to determine the contribution of duodenal nutrient exposure to gastric accommodation and meal‐induced satiation. Methods Two conditions were tested in 11 healthy subjects (28.3 ± 3.2 years; 23.6 ± 0.7 kg/m2; four females). IGP was measured during an intragastric nutrient drink (ND) infusion at a constant rate (60 mL/min) in the presence of a deflated (control) or inflated (pyloric obstruction) balloon placed into the pylorus. During the study, subjects filled out Likert scales for satiation scores and visual analogue scale for 9 epigastric symptoms (hunger, expected amount to eat, satiation, bloating, fullness, nausea, belching, gastric cramps, and pain) before and during ND infusion until maximal satiation. Key Results During pyloric obstruction, the IGP drop and the area above the IGP curve (AAC) were significantly smaller compared with the control condition (6.7 ± 1.0 mm Hg vs3.6 ± 0.8 mm Hg, P = .03 and 69.7 ± 13.5 mm Hg × min vs 20.1 ± 9.0 mm Hg × min, P = .001, respectively). Pyloric obstruction decreased nutrient tolerance compared with the control condition (787.9 ± 73.1 mL vs 970.9 ± 79.2 mL, respectively, P < .05). Pyloric obstruction increased symptoms of bloating (1.3 ± 0.4 vs 2.6 ± 0.6; P = .04), fullness (2.3 ± 0.5 vs 3.6 ± 0.3; P = .03), and nausea (0.4 ± 0.2 vs 1.3 ± 0.4; P = .04) compared to control. Conclusion & Inferences Duodenal nutrient exposure contributes to enhancing gastric accommodation. Preventing the passage of nutrients from the stomach to the duodenum inhibits gastric accommodation and increases meal‐induced satiation, bloating, nausea, and fullness.

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Section: Discussionsupporting

confidence: 75%

Duodenal nutrient exposure contributes to enhancing gastric accommodation

Carbone

Verschueren

Rotondo

et al. 2019

Neurogastroenterology Motil

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“…In healthy volunteers, peppermint oil has been shown to reduce gastric and duodenal motility, but not gastric satiation, postprandial symptom scores, or accommodation as measured by barostat, in response to a nutrient drink meal. 34 Caraway oil has also been associated with inhibition of antroduodenal motility upon intra-duodenal infusion in healthy subjects. 35 A randomized, controlled trial of two combination of peppermint/caraway oil (90 mg/50 mg vs 36 mg/ 20 mg) in 223 patients with non-ulcer dyspepsia reported reduction in pain scores for both preparations.…”

Section: Peppermint Oil Caraway Oilmentioning

confidence: 99%

Standardized herbal treatments on functional bowel disorders: moving from putative mechanisms of action to controlled clinical trials

Cremonini

2014

Neurogastroenterology Motil

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Symptom relief in functional gastrointestinal disorders (FGID) is frequently sought with complementary and alternative medicine, and various herbal medicine compounds are popular in different parts of the world. Only a few products, however, are standardized and are backed by scientific evidence. This review mainly focuses on mechanistic and clinical data in support of the Japanese traditional compound Rikkunshi-to (RKT) and of STW-5. Their effects on gut sensori-motor function, neurohormonal network, and controlled clinical data in FGID are revised. RKT and STW-5 appear to possess some degree of gastroprokinetic, visceral analgesic properties, and seem to increase the gastric accommodation response. Controlled trials of RKT and STW-5 support at least a modest effect on symptoms of functional dyspepsia and irritable bowel syndrome, with low side effects profile. With the widespread use of herbals and the relative paucity of effective pharmacological options for FGID, rigorous studies to further elucidate pharmacological actions and clinical applications of herbal compounds are a priority.

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“…Peppermint oil (PO; Mentha piperita L), a natural oil obtained by steam distilling fresh leaves of the peppermint plant, is a perennial herb commonly found across North America and Europe. PO been associated with reduced GI spasms and gastric pressure, decreased frequency and severity of abdominal pain, stimulated bile flow, and antibacterial properties . The antispasmodic and GI‐soothing effects of PO have made it a common herb in complementary and alternative medicine for ailments that include irritable bowel syndrome (IBS), dyspepsia, nausea, and general abdominal discomfort and cramping .…”

Section: Methodsmentioning

confidence: 99%

Natural Bioactive Food Components for Improving Enteral Tube Feeding Tolerance in Adult Patient Populations

2017

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Tube feeding (TF) is the most common form of nutrition support. In recent years, TF administration has increased among patient populations within and outside hospital settings, in part due to greater insurance coverage, reduced use of parenteral nutrition, and improved formularies suitable for sole source nutrition. With increasing life expectancy and improved access to TFs, the number of adults dependent on enteral nutrition is expected to grow. However, enteral TF intolerance (ETFI) is the most common complication of TFs, typically presenting with at least 1 adverse gastrointestinal event, including nausea, diarrhea, and constipation. ETFI often leads to reductions in TF volume with associated energy and protein deficits. Potentially ensuing malnutrition is a major public health concern due its effects on increased risk of morbidity and mortality, infections, prolonged hospital length of stay, and higher healthcare costs. As such, there is a need for intervention strategies to prevent and reduce ETFI. Incorporating whole foods with bioactive properties is a promising strategy. Emerging research has elucidated bioactive properties of whole foods with specific benefits for the prevention and management of adverse gastrointestinal events commonly associated with TFs. However, lack of evidence-based recommendations and technological challenges have limited the use of such foods in commercial TF formulas. This review addresses research gaps by discussing 5 whole foods (rhubarb, banana, curcumin, peppermint oil, and ginger) with bioactive attributes identified through literature searches and clinical experience as having substantial scientific rationale to consider their application for ETFI in adult populations. (Nutr Clin Pract. 2018;33:107-120) Keywords enteral nutrition; enteral formulas; tube feeding; dietary supplements; digestive signs and symptoms SummaryTube feeding (TF) is the most common form of nutrition support. In recent years, TF administration has increased among patient populations within and outside hospital settings, in part due to greater insurance coverage, reduced use of parenteral nutrition (PN), and improved formularies suitable for sole source nutrition. With increasing life expectancy and improved access to TFs, the number of adults dependent on enteral nutrition (EN) is expected to grow. However, enteral TF intolerance (ETFI) is the most common complication of TFs, typically presenting with at least 1 adverse gastrointestinal (GI) event, including nausea, diarrhea, and constipation. ETFI often leads to reductions in TF volume with associated energy and protein deficits. Potentially ensuing malnutrition is a major public health concern due its effects on increased risk of morbidity and mortality, infections, prolonged hospital length of stay, and higher healthcare costs. As such, there is a need for intervention strategies to prevent and reduce ETFI. Incorporating whole foods with bioactive properties is a promising strategy. Emerging research has elucidated bioactive properties ...

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Effect of acute peppermint oil administration on gastric sensorimotor function and nutrient tolerance in health

Abstract: Peppermint oil reduces IGP, proximal phasic contractility, and appetite, with negligible effects on gastric sensitivity, tone, accommodation, and nutrient tolerance in health.

Cited by 49 publications

References 41 publications

Duodenal nutrient exposure contributes to enhancing gastric accommodation

Duodenal nutrient exposure contributes to enhancing gastric accommodation

Standardized herbal treatments on functional bowel disorders: moving from putative mechanisms of action to controlled clinical trials

Natural Bioactive Food Components for Improving Enteral Tube Feeding Tolerance in Adult Patient Populations

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