Effect of Acute Kidney Injury on Long-Term Mortality in Patients with ST-Segment Elevation Myocardial Infarction Complicated with Cardiogenic Shock and Underwent Primary Percutaneous Coronary Intervention in a High-Volume Tertiary Center

Hayıroğlu, Mert İlker; Bozbeyoğlu, Emrah; Yıldırımtürk, Özlem; Tekkeşin, Ahmet İlker; Pehlivanoğlu, Seçkin

doi:10.5543/tkda.2019.84401

Cited by 36 publications

(33 citation statements)

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“…Previous studies have confirmed that baseline renal dysfunction and acute kidney injury are strong predictors of in-hospital adverse cardiovascular outcomes after STEMI. 27 , 28 Our study has shown that hyperuricemia on admission was frequently observed in patients with AMI who underwent PCI similar to previous studies. 1 , 8 The nomogram shows that the SI may be the critical individual factor determining intrahospital mortality in STEMI patients with hyperuricemia on admission.…”

Section: Discussionsupporting

confidence: 88%

Nomogram for the Prediction of Intrahospital Mortality Risk of Patients with ST-Segment Elevation Myocardial Infarction Complicated with Hyperuricemia: A Multicenter Retrospective Study

Bai¹,

Ma²,

ZhiYun³

et al. 2021

TCRM

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Section: Discussionsupporting

confidence: 88%

Nomogram for the Prediction of Intrahospital Mortality Risk of Patients with ST-Segment Elevation Myocardial Infarction Complicated with Hyperuricemia: A Multicenter Retrospective Study

Bai¹,

Ma²,

ZhiYun³

et al. 2021

TCRM

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“…Previous studies have demonstrated prognostic value of renal function in patients with STEMI. [26][27][28] In present study, we found no significant impact of chronic renal dysfunction or creatinine on LOS. Interestingly, although numerous studies proved more advantages of transradial approach than transfemoral access in percutaneous coronary intervention (PCI), 29 even for STEMI patients with cardiogenic shock, 30 transradial approach was not an independent associated factor of LOS in this analysis.…”

Section: Discussioncontrasting

confidence: 55%

Length of Stay and Short-Term Outcomes in Patients with ST-Segment Elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention: Insights from the China Acute Myocardial Infarction Registry

Zhao

Yang

et al. 2021

IJGM

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Background Length of stay (LOS) in patients with ST-segment elevation myocardial infarction (STEMI) is directly associated with financial pressure and medical efficiency. This study aimed to determine impact of LOS on short-term outcomes and associated factors of LOS in patients with ST-segment elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PPCI). Methods A total of 3615 patients with STEMI after PPCI in the China Acute Myocardial Infarction registry were included in the analysis. Predictors of prolonged LOS were analyzed by multivariate logistic regression model with generalized estimating equation. The impact of LOS on 30-day clinical outcomes was assessed. Results The median LOS was 9 (7, 12) days. Patients with a longer LOS (>7 days) were older, more often in lower-level hospitals, had more periprocedural complications and hospitalization expense. Fourteen variables, such as weekend admission and lower-level hospitals, were identified as independent associated factors of prolonged LOS. There were no significant difference in 30-day major adverse cardiac and cerebrovascular events (MACCE), readmission, and functional status between patients with LOS≤7d and LOS>7d after multivariate adjustment and propensity score matching. However, patients who discharged over one week had better medication adherence (adjusted odds ratio: 0.817, 95% confidence interval: 0.687–0.971, P=0.022). Significant interaction was observed in medication use between gender and LOS (P interaction =0.038). Conclusion Patients with STEMI undergoing PPCI experienced a relatively long LOS in China, which resulted in more medical expenses but no improvement on 30-day MACCE, readmission, and functional recovery. Poor 30-day medication adherence with short LOS reflects unsatisfying transition of management from hospital to community. More efforts are needed to reduce LOS safely and improve the efficiency of medical care.

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“…A previous study reported that among patients with AMI, any degree of preexisting renal impairment should be considered a potent, independent, and easily identifiable risk factor for cardiovascular complications, with each 10-unit reduction in eGFR being associated with a 10% increased risk for death and nonfatal cardiovascular outcomes [26]. In general, patients with chronic kidney disease have more cardiovascular risk factors and a higher incidence of MACE with AMI and acute kidney injury (AKI) was revealed to be an independent longterm prognostic indicator in patients with STEMI [27]. Even small, subclinical elevations of serum creatinine that do not fulfil the consensus criteria for acute kidney injury have been independently associated with a twofold increased risk of adverse in-hospital outcomes after AMI [28].…”

Section: Table 3 Multivariate Analysis Of Variables Associated With Imentioning

confidence: 99%

Predictive value of elevated alanine aminotransferase for in-hospital mortality in patients with acute myocardial infarction

Zhao

Jiang

et al. 2021

BMC Cardiovasc Disord

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Background and aims Liver enzymes, including alanine aminotransferase (ALT) and aspartate aminotransferase (AST), are markers of hepatic dysfunction and fatty liver disease. Although ALT and AST have been suggested as risk factors for cardiovascular disease, their role as predictors of mortality after acute myocardial infarction (AMI) has not been established. The objective of this study was to investigate the predictive value of ALT and AST for mortality in patients with AMI. Methods We analyzed records of 712 patients with AMI and no known liver disease treated at the Department of Cardiovascular Center in the First Hospital of Jilin University. The primary outcome was all-cause in-hospital mortality. Relationships between primary outcome and various risk factors, including serum transaminase levels, were assessed using multivariate logistic regression analysis. Results Age (P < 0.001), hypertension (P = 0.034), prior myocardial infarction (P < 0.001), AST (P < 0.001), ALT (P < 0.001), creatinine (P = 0.007), blood urea nitrogen (P = 0.006), and troponin I (P < 0.001) differed significantly between ST-segment elevation myocardial infarction (STEMI) and non-STEMI. The following factors were associated with an increased risk of in-hospital all-cause mortality in patients with AMI: ALT ≥ 2ULN (adjusted odds ratio [AOR] 2.240 [95% confidence interval (CI), 1.331–3.771]; P = 0.002); age ≥ 65 year (AOR 4.320 [95% CI 2.687–6.947]; P < 0.001); increased fasting plasma glucose (FPG) (AOR 2.319 [95% CI 1.564–3.438]; P < 0.001); elevated D-dimer (AOR 2.117 [95% CI 1.407–3.184]; P < 0.001); elevated fibrinogen (AOR 1.601 [95% CI 1.077–2.380]; P = 0.20); and reduced estimated glomerular filtration rate (eGFR) (AOR 2.279 [95% CI 1.519–3.419]; P < 0.001). Conclusions Our findings demonstrated that elevated ALT was independently associated with increased in-hospital all-cause mortality in patients with AMI. Other risk factors were increased age, FPG, D-dimer, and fibrinogen and decreased eGFR.

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Effect of Acute Kidney Injury on Long-Term Mortality in Patients with ST-Segment Elevation Myocardial Infarction Complicated with Cardiogenic Shock and Underwent Primary Percutaneous Coronary Intervention in a High-Volume Tertiary Center

Cited by 36 publications

References 0 publications

Nomogram for the Prediction of Intrahospital Mortality Risk of Patients with ST-Segment Elevation Myocardial Infarction Complicated with Hyperuricemia: A Multicenter Retrospective Study

Nomogram for the Prediction of Intrahospital Mortality Risk of Patients with ST-Segment Elevation Myocardial Infarction Complicated with Hyperuricemia: A Multicenter Retrospective Study

Length of Stay and Short-Term Outcomes in Patients with ST-Segment Elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention: Insights from the China Acute Myocardial Infarction Registry

Predictive value of elevated alanine aminotransferase for in-hospital mortality in patients with acute myocardial infarction

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