Effect of Acute Intravenous Growth Hormone-Releasing Factor on Plasma Prolactin in Short Children and Patients with Growth Hormone Deficiency

Chatelain, Pierre; Sassolas, G.; Catbeh, N; Bio-Laporte, S.; Ferry, Serge; Bruno, Claudio; Dávid, M; François, R

doi:10.1159/000180070

Cited by 7 publications

(4 citation statements)

References 7 publications

(17 reference statements)

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“…In this study we found no temporary increase in prolactin after GHRH injection (2 pg/kg). This con trasts with the findings of other investiga tors, who have found a dose-dependent in crease in prolactin levels after GHRH [18,19]. No other hypophyseal hormone was found to be affected by GHRH in this study.…”

Section: Arginine-insulin Testsupporting

confidence: 91%

Growth Hormone Release in Children after Cranial Irradiation

Lannering

Albertsson‐Wikland

1987

Horm Res

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Growth retardation due to growth hormone (GH) deficiency is common in children after radiotherapy to the brain. Different methods for assessment of GH secretion were compared in 19 children who had received radiotherapy to the brain as part of treatment for a tumor of the brain, eye or epipharynx. GH was measured over a 24-hour period (72 sampling periods of 20 min each), as well as after administration of growth hormone-releasing hormone (GHRH) and arginine-insulin (AITT) tests. We found the 24-hour GH profile to be disturbed in all children; there was a low overall secretion with few peaks of low amplitude but a diurnal rhythm still discemable. In 16 children a prompt rise in GH after GHRH_1-40 was seen indicating hypothalamic damage. The GH response after GHRH was not found to be correlated to the spontaneous secretion over 24 h. The results of the AITT showed discrepancies to the 24-hour GH profile in individual cases making this test unreliable in spite of a good overall correlation between the tests. Therefore, we suggest measurement of spontaneous secretion when GH-secretory capability is to be evaluated after cranial irradiation for a brain tumor.

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Section: Arginine-insulin Testsupporting

confidence: 91%

Growth Hormone Release in Children after Cranial Irradiation

Lannering

Albertsson‐Wikland

1987

Horm Res

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“…The normal basal PRL levels and the lack of an acute increase in PRL after GHRH in Turner's syn¬ drome suggest that the decreased GH responsive¬ ness to GHRH of these patients is not due to a primary GHRH deficiency: we (13) and others (16) have shown that such an increase in PRL after GHRH is a hallmark of children with hypothalamic GHRH deficiency, although its precise mechanism remains unknown (17).…”

Section: Discussionmentioning

confidence: 99%

Decreased growth hormone response to growth hormone-releasing hormone in Turner's syndrome: Relation to body weight and adiposity

Reiter

Craen²,

Vliet³

1991

Acta Endocrinologica

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Abstract. A decreased growth hormone response to various secretagogues has been described in Turner's syndrome, but the mechanisms responsible for this decrease are unknown. Seventeen prepubertal girls with Turner's syndrome (age 6.4 to 15.7 years; height −0.2 to −5.4 sd, bone age −3.7 to −0.3 sd; weight 93 to 169% of ideal body weight) underwent a stimulation test with GHRH (0.5 μg/kg). Plasma GH and prolactin were measured by radioimmunoassay from −30 to +120 min and insulin-like growth factor-I at time 0. These values were compared with those observed in lean children with constitutional short stature. Peak plasma GH after GHRH was 17.0±3.6 μg/l (mean±sem), significantly lower (p<0.001) than in the short lean children (39.2±5.1 μg/l. In Turner's syndrome patients, the peak GH value was negatively correlated with the percentage of ideal body weight (r=−0.58, p<0.02) and of body fat (r=−0.59, p<0.02). Plasma prolactin levels in Turner's syndrome did not rise after GHRH and showed a normal circadian variation, from 8.0±1.0 μg/l at 08.30 h to 5.0±0.7 μg/l at 11.00 h (mean ±sem). Mean (±sem) baseline plasma insulin-like growth factor-I concentrations was 0.88±0.14 kU/l, higher than in the short lean children (0.49±0.08 kU/l, p<0.05). We conclude that the decreased GH response to GHRH of girls with Turner's syndrome is related, at least in part, to their excess body weight and fat and is associated with higher IGF-I levels than in short lean children.

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“…Gelato et al [11] showed in healthy adults that a dose of 10 pg/kg promoted an increase in prolactin concentration, whereas no effect on prolactin concentrations was ob served up to a dose of 1 pg/kg of GHRH 1 -44. Chatelain et al [5] showed that in 4 healthy adults a similar increase in serum concentrations of prolactin was seen after doses of 80, 160 and 320 pg of GHRH. Van Vliet et al [37,38] found that a dose of 0.5 pg/kg of GHRH promoted an increase in prolactin concentrations in GHdeficient children, but not in short normal children.…”

Section: Discussionmentioning

confidence: 87%

Effects of Acute Intravenous Injection of Two Growth Hormone-Releasing Hormones (GHRH 1–40 and 1–29) on Serum Growth Hormone and Other Pituitary Hormones in Short Children with Pulsatile Growth Hormone Secretion

Gelander

Lindstedt²,

Selstam³

et al. 1989

Horm Res

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We administered two different growth hormone-releasing hormones (GHRH) to 20 short, prepubertal children who had spontaneous secretion of growth hormone (GH), assessed from 24-hour GH secretion profiles (72 sampling periods of 20 min). We compared one i.v. injection of 1 µg/kg of GHRH 1–40 with that of GHRH 1–29 regarding serum concentrations of GH, prolactin, luteinizing hormone, follicle-stimulating hormone and IGF-I. The children were allocated to two groups without statistical randomization. Both groups were given both peptides, with at least 1 week in between. The first group started with GHRH 1–40, the other with GHRH 1–29. The peptides both induced an increased serum concentration of GH of the same magnitude: mean maximal peak of 89 ± 12 mU/1 after GHRH 1–40 and 94 ± 10 mU/1 after GHRH 1–29 (n.s.). The mean difference in maximum serum GH concentration in each child after injection was 52 ± 9 mU/1, range 1–153 mU/1. GHRH 1–29 also induced a short-term, small increase in the concentrations of prolactin (p < 0.05), luteinizing hormone (p < 0.01) and follicle-stimulating hormone (p < 0.05). We conclude that the shorter sequence GHRH 1–29, when given in a dose of 1 µg/kg, gives a rise in serum concentration of GH similar to that after the native form GHRH 1–40.

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Effect of Acute Intravenous Growth Hormone-Releasing Factor on Plasma Prolactin in Short Children and Patients with Growth Hormone Deficiency

Cited by 7 publications

References 7 publications

Growth Hormone Release in Children after Cranial Irradiation

Growth Hormone Release in Children after Cranial Irradiation

Decreased growth hormone response to growth hormone-releasing hormone in Turner's syndrome: Relation to body weight and adiposity

Effects of Acute Intravenous Injection of Two Growth Hormone-Releasing Hormones (GHRH 1–40 and 1–29) on Serum Growth Hormone and Other Pituitary Hormones in Short Children with Pulsatile Growth Hormone Secretion

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Effect of Acute Intravenous Growth Hormone-Releasing Factor on Plasma Prolactin in Short Children and Patients with Growth Hormone Deficiency

Cited by 7 publications

References 7 publications

Growth Hormone Release in Children after Cranial Irradiation

Growth Hormone Release in Children after Cranial Irradiation

Decreased growth hormone response to growth hormone-releasing hormone in Turner's syndrome: Relation to body weight and adiposity

Effects of Acute Intravenous Injection of Two Growth Hormone-Releasing Hormones (GHRH 1&ndash;40 and 1&ndash;29) on Serum Growth Hormone and Other Pituitary Hormones in Short Children with Pulsatile Growth Hormone Secretion

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Effects of Acute Intravenous Injection of Two Growth Hormone-Releasing Hormones (GHRH 1–40 and 1–29) on Serum Growth Hormone and Other Pituitary Hormones in Short Children with Pulsatile Growth Hormone Secretion