Effect of acute hypernatremia, hyponatremia, and acidosis on bone sodium

Forbes, Gilbert B.; Tobin, Richard B.; Harrison, Anne; McCoord, Augusta B.

doi:10.1152/ajplegacy.1965.209.4.825

Cited by 21 publications

(10 citation statements)

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“…Unlike Nichols & Nichols (1956) and Woodbury (1956). Forbes, Tobin, Harrison & McCoord (1965) reported that loss of sodium from bone after peritoneal dialysis with 5% glucose could be accounted for entirely by the sodium of the fluid phase of bone. Discrepancies between the results of these workers may be due in part to the many methodological problems encountered in experiments of this sort.…”

Section: Discussionmentioning

confidence: 90%

The effects of the production of sodium depletion by peritoneal dialysis with 5% glucose on the volume and composition of the extracellular fluid of dogs

Rampton¹,

Ramsay²

1974

The Journal of Physiology

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Section: Discussionmentioning

confidence: 90%

The effects of the production of sodium depletion by peritoneal dialysis with 5% glucose on the volume and composition of the extracellular fluid of dogs

Rampton¹,

Ramsay²

1974

The Journal of Physiology

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“…1b ). These fi ndings would support the possibility that the skeleton acts as a dynamic buff er in response to acute changes in plasma sodium concentration, perhaps due to a mobilization of sodium from an osmotically inactive crystallized form into an osmotically active form to buff er declining extracellular [Na + ] p [ 14 ] . Conversely, bone mineral density increased in linear proportion to [Na + ] p , suggesting that sodium ions may have mobilized into bone to accommodate rising extracellular [Na + ] p due to a surplus sodium intake ( • ▶ Fig.…”

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confidence: 66%

Bone: An Acute Buffer of Plasma Sodium During Exhaustive Exercise?

2013

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Both hyponatremia and osteopenia separately have been well documented in endurance athletes. Although bone has been shown to act as a "sodium reservoir" to buffer severe plasma sodium derangements in animals, recent data have suggested a similar function in humans. We aimed to explore if acute changes in bone mineral content were associated with changes in plasma sodium concentration in runners participating in a 161 km mountain footrace. Eighteen runners were recruited. Runners were tested immediately pre- and post-race for the following main outcome measures: bone mineral content (BMC) and density (BMD) via dual-energy X-ray absorptiometry (DEXA); plasma sodium concentration ([Na+]p), plasma arginine vasopressin ([AVP]p), serum aldosterone concentration ([aldosterone]s), and total sodium intake. Six subjects finished the race in a mean time of 27.0±2.3 h. All subjects started and finished the race with [Na+]p within the normal range (137.7±2.3 and 136.7±1.6 mEq/l, pre- and post-race, respectively). Positive correlations were noted between change (Δ; post-race minus pre-race) in total BMC (grams) and [Na+]p (mEq/l) (r=0.99; p<0.0001), and between total sodium intake (mEq/kg) and %Δ lumbar spine BMD (r=0.94; p<0.001). Change in [aldosterone]s was positively correlated with: rate of total sodium intake (r=0.84; p<0.05); Δ total BMC (r=0.82; p<0.05); and Δ [Na+]p (r=0.88; p<0.05). No significant pre- to post-race mean differences were noted in BMC or BMD. Robust associations between Δ BMC and Δ [Na+]p suggest that sodium status and bone density may be inter-related during endurance exercise and should be considered in future investigations of athletic osteopenia.

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“…3, bottom line). Bone contains the largest store of non-extracellular sodium, but consensus as to its availability in buffering reactions has not been reached (Bergstrom & Wallace, 1954;Levitt et al, 1956;Forbes, Tobin, Harrison & McCoord, 1965;Pandolfo, Recine, Gemelli & Fama, 1968;Ginsberg, Bettice & Gamble, 1969).…”

Section: Discussionmentioning

confidence: 99%

Intracellular Buffering in the Dog at Varying CO2 Tensions

Gamble¹,

Zuromskis²,

Bettice³

et al. 1972

Clinical Science

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1. The effect of varying the Pco, on the buffering of mineral acid has been investigated. HCl (6 mmol/kg) was infused into anaesthetized-paralysed dogs maintained on a respirator and changes in Pco, (between 20 and 60 mmHg) were arranged by varying the stroke volume.2. No significant interaction between buffering of respiratory and metabolic events was discerned. Variations in Pco, did not alter the efficiency of the buffering of the HCl. The presence or absence of metabolic acidosis did not alter the magnitude of the effect of acute respiratory change on the concentration of extracellular bicarbonate. This response remained between 1.0 and 1.3 mmol/l for changes of 10 mmHg in the PCO,.3. The buffering of HCl achieved outside the blood and extracellular fluids did not correlate with measured changes in extracellular pH or with predicted changes in intracellular pH. This buffering appears to be associated with changes in the H+ ion concentration gradient across the cell membranes.

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Effect of acute hypernatremia, hyponatremia, and acidosis on bone sodium

Cited by 21 publications

References 0 publications

The effects of the production of sodium depletion by peritoneal dialysis with 5% glucose on the volume and composition of the extracellular fluid of dogs

The effects of the production of sodium depletion by peritoneal dialysis with 5% glucose on the volume and composition of the extracellular fluid of dogs

Bone: An Acute Buffer of Plasma Sodium During Exhaustive Exercise?

Intracellular Buffering in the Dog at Varying CO2 Tensions

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