Effect of acute heat stress on rat adrenal cortex — a morphological and ultrastructural study

Petrovic-Kosanovic, Dragana; Veličković, Ksenija; Koko, Vesna; Jasnić, Nebojša; Cvijic̀, Gordana; Milošević, Maja

doi:10.2478/s11535-012-0055-y

Cited by 12 publications

(12 citation statements)

References 27 publications

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“…These studies, performed in humans or in several animal models, present results involving morphological or functional changes in the adrenal glands in response to the studied stressors (20,21,30,31,34,40,44).…”

Section: Introductionmentioning

confidence: 99%

Morphometric and histopathological findings in the adrenal glands of dogs with chronic diseases

Salvagni

Siqueira

María

et al. 2017

Braz. J. Vet. Pathol.

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Salvagni, et al.; Morphometric and histopathological findings in the adrenal glands of dogs with chronic diseases. Braz J Vet Pathol, 2017, 10(2), 69 -78. DOI: 10.24070/bjvp.1983 AbstractProlonged stress suffered by the organism in the presence of chronic diseases can result in functional and morphological changes to the adrenal glands; although the effects of chronic stress on the adrenal gland function in live dogs is well documented, studies focusing on the morphologic changes in the adrenal glands have been lacking. Thus, this study aimed to identify and connect possible morphometric and histopathological changes in the adrenal glands of necropsied dogs in the presence or absence of chronic diseases. Morphological changes in the adrenal glands of 46 necropsied dogs were evaluated through morphometric and histopathological analyses. The morphometric characteristics of the adrenal glands of dogs were influenced more by the animal's body weight (p < 0.0001) and adrenocortical hyperplasia (p < 0.05) than by the stress associated with chronic diseases or acute conditions. Previously healthy animals with sudden death or animals that died from acute diseases had significant severe congestion in the adrenal glands (p = 0.0272), while adrenocortical hyperplasia was more frequent in the chronic diseases group (p = 0.0041). Fibrosis at the corticomedullary junction (p < 0.0001) and inflammatory infiltrate (p = 0.0015) were observed only in animals with chronic diseases. The adrenal glands of dogs with chronic cardiac dysfunction frequently showed significant necrosis (p = 0.0256), fibrosis (p = 0.0002) and lipid depletion (p = 0.0288). Thus, while the weight or dimensions of the adrenal glands of dogs at necropsy should not be used alone as parameters to indicate a relation with the stress suffered prior to death, the histopathological findings could aid and support necropsy conclusions regarding the presence of chronic diseases.

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Section: Introductionmentioning

confidence: 99%

Morphometric and histopathological findings in the adrenal glands of dogs with chronic diseases

Salvagni

Siqueira

María

et al. 2017

Braz. J. Vet. Pathol.

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“…The enlargement of adrenal glands was apparently caused by hyperplasia and/or hypertrophy of the adrenal zona fasciculata and medulla. Chronic stress can lead to adrenal enlargement [ 36 ] and even acute heat stress has been shown to cause a slight increase in adrenal mass in rats [ 37 ]. The observed adrenal hyperplasia may indicate that stress was involved, but adrenal changes related to stress has apparently not been studied in the mink.…”

Section: Discussionmentioning

confidence: 99%

The effect of color type on early wound healing in farmed mink (Neovison vison)

et al. 2017

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BackgroundIndividual differences of mink, including color type, are speculated to affect the course of wound healing, thereby impacting wound assessment and management on the farms, as well as the assessment of wounds in forensic cases. In this study, we examined the effect of color type on early wound healing in farmed mink. Full thickness excisional wounds (2 × 2 cm) were made on the back in 18 mink of the color types Brown, Silverblue and Blue Iris. Gross and microscopic pathology of the wounds was evaluated 2 days post-wounding together with degree of wound size reduction, presence of bacteria and blood analyses.ResultsPathological examination on day 2 showed the greatest mean wound size reduction in Brown mink (11.0%) followed by Blue Iris (7.9%) and Silverblue (1.6%). Bacteria were cultured from all wounds, and predominantly Staphylococcus species were recovered in mixed or pure culture. Histopathology from day 2 wounds showed a scab overlying necrotic wound edges, which were separated from underlying vital tissue by a demarcation zone rich in polymorphonuclear leukocytes. Fibroblasts and plump endothelial cells were more numerous in the deeper tissues. Complete blood count parameters were within normal ranges in most cases, however, the mink showed mildly to markedly decreased hematocrit and six mink of the color types Silverblue and Blue Iris showed moderately elevated numbers of circulating segmented neutrophils on day 2. There was a marked increase in concentration of serum amyloid A from day 0 to day 2 in all color types.ConclusionsWe have described differences in early wound healing between mink of the color types Brown, Silverblue and Blue Iris by use of an experimental wound model in farmed mink. The most pronounced difference pertained to the degree of wound size reduction which was greatest in Brown mink, followed by Blue Iris and Silverblue, respectively.

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“…Most of the studies that are investigating the effect of short-term exposure of rats to elevated ambient temperature (one hour at 38 o C) on the activity of the HPA axis [5,[7][8][9], have found increased blood ACTH and CORT concentrations. On the other hand, there is very few and ambiguous data about the effect of prolonged exposure to moderately high ambient temperature on the activity of the HPA axis, showing absence or increased values of blood ACTH and CORT concentrations after 4-5 days exposure to [35][36][37][38] o C [10,11].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Moderate Heat on Rat Pituitary ACTH Cells: Histomorphometric, Immunofluorescent and Hormonal Study

et al. 2017

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In areas with moderate continental climate, increased average ambient temperature during the summer represents a stressogenic factor that affects the hypothalamo-pituitaryadrenocortical axis in mammals. Therefore, we wanted to examine the effects of 4 days of constant exposure to moderately elevated ambient temperature (35 ± 1 o C) on the histomorphometric and immunofl uorescent characteristics, as well as on the hormonal secretion of pituitary corticotropes (ACTH) cells in adult male rats. In comparison with the controls kept at 20 ± 2 o C, a signifi cant increase (p<0.05) of the absolute and relative pituitary weight (23.1% and 36.1%, respectively) was registered after exposure to heat. The localization, as well as the shape of the ACTH cells in the heat exposed group was not signifi cantly altered, but their immunopositivity was weaker. After 4 days of heat exposure, a weaker signal confi rmed the relative fl uorescence intensity of the ACTH cells (15.3%, p<0.05). In heat exposed rats, an increase of the cellular and nuclear volumes of immunolabelled ACTH cells and decrease of their volume density (6.9%, 14.3% and 20.0%, respectively; p<0.05) was registered. Observed histomorphometric and immunofl uorescent features of the pituitary ACTH cells were in accordance with the increased (p<0.05) value of plasma adrenocorticotropic hormone (ACTH) by 23.7% compared to the control rats. It can be concluded that the 4-day exposure to moderately elevated ambient temperature intensifi es pituitary ACTH secretion in adult male rats.

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Effect of acute heat stress on rat adrenal cortex — a morphological and ultrastructural study

Cited by 12 publications

References 27 publications

Morphometric and histopathological findings in the adrenal glands of dogs with chronic diseases

Morphometric and histopathological findings in the adrenal glands of dogs with chronic diseases

The effect of color type on early wound healing in farmed mink (Neovison vison)

The Effect of Moderate Heat on Rat Pituitary ACTH Cells: Histomorphometric, Immunofluorescent and Hormonal Study

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