Effect of acute gold nanorods on reproductive function in male albino rats: histological, morphometric, hormonal, and redox balance parameters

Hassan, Amr; Abdoon, Ahmed S.; El-Sheikh, Sawsan M.A.; Khairy, Mohamed; Gamaleldin, Amina A.; El‐Nabtity, Sameh M.

doi:10.1007/s11356-019-04884-x

Cited by 8 publications

(13 citation statements)

References 33 publications

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“…Previous studies have reported no MDA changes in plasma, kidneys, and liver 24 h after GNP administration. Our results show that lipid peroxidation is detectable 15 days after GNP injection (Figures − ). , …”

Section: Resultssupporting

confidence: 52%

“…Our results show that lipid peroxidation is detectable 15 days after GNP injection (Figures 2−5). 49,50 The amounts of carbonyl protein in the liver and kidneys after treatment with 25, 100, and 250 mg/kg GNPs were low compared to those in controls, reflecting an imbalance in the redox status. It has previously been demonstrated that when the cell was exposed to oxidative stress, protein glutathionylation was induced.…”

Section: Resultsmentioning

confidence: 99%

“…Our results show that lipid peroxidation is detectable 15 days after GNP injection ( Figures 2 − 5 ). 49 , 50 …”

Section: Resultsmentioning

confidence: 99%

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Histological Injury to Rat Brain, Liver, and Kidneys by Gold Nanoparticles is Dose-Dependent

et al. 2022

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Gold nanoparticles (GNPs) possess various interesting plasmonic properties that can provide a variety of diagnostic and therapeutic functionalities for biomedical applications. Compared to other inorganic metal nanoparticles (NPs), GNPs are less toxic and more biocompatible. However, the in vivo toxicity of gold nanoparticles on humans can be significant due to the size effect. This work aims to study the effect of multiple doses of small-size (≈20 nm) GNPs on the vital organs of Wistar rats. The study includes the oxidative stress in vital organs (liver, brain, and kidney) caused by GNPs and histopathology analysis. The rats were given a single caudal injection of NPs dispersed in PBS at 25, 50, 100, and 250 mg/kg of body weight. After sacrifice, both plasma and organs were collected for the determination of oxidant/antioxidant markers and histological studies. Our data show the high sensitivity of oxidative stress parameters to the GNPs in the brain, liver, and kidneys. However, the response to this stress is different between the organs and depends upon the antioxidant defense, where GSH levels control the MDA and PCO levels. Histological alterations are mild at 25, 50, and 100 mg/kg but significant at higher concentrations of 250 mg/kg. Therefore, histological impairments are shown to be dependent on the dose of GNPs. The results contribute to the understanding of oxidative stress and cellular interaction induced by nanoparticles.

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Section: Resultssupporting

confidence: 52%

Section: Resultsmentioning

confidence: 99%

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Histological Injury to Rat Brain, Liver, and Kidneys by Gold Nanoparticles is Dose-Dependent

et al. 2022

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“…Hence, the AuNRs inhibited the elevated ROS generation and lipid peroxidation, thus restoring the antioxidant system to normal. Similar results were previously reported in rats [54,55], where AuNPs of 10-50 nm diameters did not show any oxidative stress. Furthermore, Leonavičienė et al [56] reported that injection of 50 nm of AuNPs reduced the MDA production and significantly enhanced the activity of the CAT enzyme, which was considered a principal antioxidant responsible for the direct eradication of ROS produced [56,57].…”

Section: Discussionsupporting

confidence: 91%

Effect of gold nanoparticles shape and dose on immunological, hematological, inflammatory, and antioxidants parameters in male rabbit

Mehanna

Kamel²,

Abo-Elmatty

et al. 2022

Vet World

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Background and Aim: Gold nanorods (AuNRs) have gained much attention in recent years due to their promising optical and chemical properties and are hence used in applied research and industrial nanotechnology. This study was designed to investigate the effect of gold nanoparticle shape (Gold nanorods vs. gold nanosphere) on immune response in rabbit. Materials and Methods: Thirty New Zealand white rabbits were divided into six groups (n=5 rabbits). The first group is the control negative received an intravenous (IV) injection of normal saline 0.9%; the second group (vaccinated) is the control positive, and the other four groups were vaccinated and received a single-dose or repeated five consecutive IV doses of 300 μg/kg body weight 50 nm AuNRs or 50 nm gold nanosphere (50 nm AuNSs) dissolved in ultrapure water. Blood and serum were collected for the hematological and biochemical analysis. Results: White blood cells (WBCs) count, lymphocytes, monocytes, eosinophils, and basophils showed significantly (p<0.05) higher values with the repeated-dose AuNRs. γ-globulin levels showed a significant difference after 15 days in the single-dose AuNSs. Single-dose AuNSs significantly (p<0.05) increased the immunoglobulin G (IgG) and significantly (p<0.05) decreased the tumor necrosis factor-alpha. In addition, it elicited a significant (p<0.05) decrease in the malondialdehyde levels and a significant (p<0.05) increase of the superoxide dismutase, glutathione peroxidase, and catalase levels. Moreover, evoked red blood cells count, mean corpuscular volume, and mean corpuscular hemoglobin were significantly (p<0.05) lower than the control group. The platelet count, lysozymes, and nitric oxide were significantly (p<0.05) higher in repeated-dose AuNRs. Conclusion: The effect of AuNPs is shape and dose-dependent. The repeated 5 days IV 50 nm AuNRs doses over 15 days showed a significant antioxidant effect, with no considerable toxicity or vascular reactions.

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“…In another study conducted on porcines, sperm motility, membrane integrity and morphology parameters were not affected by nanoparticles (Tiedemann et al, 2014). Conversely, in another study conducted on rats the number of epididymal spermatozoa was found significantly higher after AuNR injection (Hassan et al, 2019). There is no study conducted on humans in the literature.…”

Section: Gold (Au)mentioning

confidence: 92%

Seminal trace elements and their relationship with sperm parameters

et al. 2022

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Male reproductive problems may derive from many reasons including the environmental toxicants which may either intaken by occupational exposure, nutrition or bad air quality. The increased exposure to these substances due to rapid industrial development and technology has raised the questions: Is there a relationship between sperm parameters and these substances, and if so, in what extent? Results of studies on the subject reported conflicting results, many of which were not investigated in the seminal plasma. The aim of the current study was to evaluate the relationship between 23 metals and trace elements in human seminal plasma and semen parameters many of

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Effect of acute gold nanorods on reproductive function in male albino rats: histological, morphometric, hormonal, and redox balance parameters

Cited by 8 publications

References 33 publications

Histological Injury to Rat Brain, Liver, and Kidneys by Gold Nanoparticles is Dose-Dependent

Histological Injury to Rat Brain, Liver, and Kidneys by Gold Nanoparticles is Dose-Dependent

Effect of gold nanoparticles shape and dose on immunological, hematological, inflammatory, and antioxidants parameters in male rabbit

Seminal trace elements and their relationship with sperm parameters

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