Effect of Acute Extremely Low Frequency Electromagnetic Field Exposure on the Antioxidant Status and Lipid Levels in Rat Brain

Martínez-Sámano, Jesús; Torres-Durán, Patricia Victoria; Juárez-Oropeza, Marco Antonio; Verdugo-Dı́az, Leticia

doi:10.1016/j.arcmed.2012.04.003

Cited by 42 publications

(31 citation statements)

References 45 publications

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“…In SH-SY5Y cell cultures and a number of other cell types exposed to ELF-EMF, genes involved in the stress response, cell growth and differentiation or protein metabolism have been reported to be generally down-regulated, whereas genes involved in Ca 2+ metabolism, the PI3-kinase pathway, trascription and it's modulation by splicing are up-regulated [41], [54]–[61]. Such actions are reported to often be accompanied by changes in cell growth and oxidative balance [41], [54], [61]. In our experimental conditions, timed continuous ELF-EMF (1 mT (rms)), 50 Hz) exposure likewise impacted cellular oxidative status, causing an early rise in NOS activity and O 2 − levels in SH-SY5Y cells.…”

Section: Discussionmentioning

confidence: 99%

Neuronal Cellular Responses to Extremely Low Frequency Electromagnetic Field Exposure: Implications Regarding Oxidative Stress and Neurodegeneration

et al. 2014

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Neurodegenerative diseases comprise both hereditary and sporadic conditions characterized by an identifying progressive nervous system dysfunction and distinctive neuopathophysiology. The majority are of non-familial etiology and hence environmental factors and lifestyle play key roles in their pathogenesis. The extensive use of and ever increasing worldwide demand for electricity has stimulated societal and scientific interest on the environmental exposure to low frequency electromagnetic fields (EMFs) on human health. Epidemiological studies suggest a positive association between 50/60-Hz power transmission fields and leukemia or lymphoma development. Consequent to the association between EMFs and induction of oxidative stress, concerns relating to development of neurodegenerative diseases, such as Alzheimer disease (AD), have been voiced as the brain consumes the greatest fraction of oxygen and is particularly vulnerable to oxidative stress. Exposure to extremely low frequency (ELF)-EMFs are reported to alter animal behavior and modulate biological variables, including gene expression, regulation of cell survival, promotion of cellular differentiation, and changes in cerebral blood flow in aged AD transgenic mice. Alterations in inflammatory responses have also been reported, but how these actions impact human health remains unknown. We hence evaluated the effects of an electromagnetic wave (magnetic field intensity 1mT; frequency, 50-Hz) on a well-characterized immortalized neuronal cell model, human SH-SY5Y cells. ELF-EMF exposure elevated the expession of NOS and O2 −, which were countered by compensatory changes in antioxidant catylase (CAT) activity and enzymatic kinetic parameters related to CYP-450 and CAT activity. Actions of ELF-EMFs on cytokine gene expression were additionally evaluated and found rapidly modified. Confronted with co-exposure to H2O2-induced oxidative stress, ELF-EMF proved not as well counteracted and resulted in a decline in CAT activity and a rise in O2 − levels. Together these studies support the further evaluation of ELF-EMF exposure in cellular and in vivo preclinical models to define mechanisms potentially impacted in humans.

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Section: Discussionmentioning

confidence: 99%

Neuronal Cellular Responses to Extremely Low Frequency Electromagnetic Field Exposure: Implications Regarding Oxidative Stress and Neurodegeneration

et al. 2014

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“…NO • can function as an anti-inflammatory/antioxidant and even a cytoprotective molecule at low concentrations, like the NO • produced by constitutive endothelial and/or neuronal nitric oxide synthases. However, in inflammatory conditions, induction of the iNOS yields high amounts of NO • that become cytotoxic, mainly due to the inhibition of mitochondrial respiration and the nitration/nitrosylation of proteins [52,53].…”

Section: Discussionmentioning

confidence: 99%

Preliminary evidence suggesting that nonmetallic and metallic nanoparticle devices protect against the effects of environmental electromagnetic radiation by reducing oxidative stress and inflammatory status

Ortiz

Fernández-Gil

Guerra‐Librero

et al. 2016

European Journal of Integrative Medicine

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“…For example, an experimental study has reported that a toxic effect that was induced in a rat's brain by impairing CAT activity (Akdag et al, 2010). Also, it is suggested that chronic exposure to a 60 Hz EMF leads to CAT activity impairment and lipid peroxidation in the brains of Wistar albino rats (Martínez-Sá mano et al, 2012). Another study has observed increased levels of SOD and malondialdehyde (MDA) in the serum activity of the hippocampus in eight-week-old Wistar albino rats exposed to 900 MHz of radiation (Kerman and Ş enol, 2012).…”

Section: Disequilibrium Oxidative Stress Antioxidant Enzymes and Emmentioning

confidence: 97%

Different methods for evaluating the effects of microwave radiation exposure on the nervous system

Altunkaynak

Altun

Yahyazadeh

et al. 2016

Journal of Chemical Neuroanatomy

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Effect of Acute Extremely Low Frequency Electromagnetic Field Exposure on the Antioxidant Status and Lipid Levels in Rat Brain

Cited by 42 publications

References 45 publications

Neuronal Cellular Responses to Extremely Low Frequency Electromagnetic Field Exposure: Implications Regarding Oxidative Stress and Neurodegeneration

Neuronal Cellular Responses to Extremely Low Frequency Electromagnetic Field Exposure: Implications Regarding Oxidative Stress and Neurodegeneration

Preliminary evidence suggesting that nonmetallic and metallic nanoparticle devices protect against the effects of environmental electromagnetic radiation by reducing oxidative stress and inflammatory status

Different methods for evaluating the effects of microwave radiation exposure on the nervous system

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