Effect of Acute Cocaine Injection on the Extracellular Level of Dopamine, Blood Flow, and Oxygen Pressure in Brain of Newborn Piglets

Yonetani, Masahiko; Huang, Chao; Lajevardi, Nasser S.; Pastuszko, Anna; Delivoriapapadopoulous, M.; Anday, Endla K.

doi:10.1006/bmmb.1994.1013

Cited by 7 publications

(2 citation statements)

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“…Stein and Fuller (29) reported results similar to our studies, in that they observed an increase in CBF in the rat model as well as a transient increase in blood pressure. Yonetani et al (33) showed that an acute cocaine injection caused a persistent decrease in cortical O 2 pressure with a decrease in CBF and blood pressure. We observed an increase in arterial blood pressure in all three groups; the fetal results were similar to our previous observations after maternal cocaine injection (11).…”

Section: Discussionmentioning

confidence: 99%

Comparison of cerebrovascular effects of intravenous cocaine injection in fetal, newborn, and adult sheep

Robinson¹,

O'Brien²,

Pane³

et al. 2000

American Journal of Physiology-Heart and Circulatory Physiology

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Cocaine may cause stroke, intracranial hemorrhage, seizures, and neurobehavioral abnormalities in fetuses, newborns, and adults, and there could be developmental and/or species differences in mechanisms for these cocaine-induced cerebrovascular effects. To evaluate developmental differences in responses to cocaine, we compared the cerebrovascular and metabolic responses to a 2 mg/kg iv cocaine dose in unanesthetized fetal (n = 8, previously reported, direct fetal injection), newborn (n = 6), and adult (n = 12) sheep. We measured cerebral blood flow, mean arterial blood pressure, and arterial and venous O(2) content, and we calculated cerebral O(2) consumption and cerebral vascular resistance at baseline and at 30 s and at 5, 15, and 60 min after cocaine injection. Cerebral blood flow increased 5 min after injection in the fetus and newborn, but not until 15 min in the adult. In the fetus, cocaine caused a transient cerebral vasoconstriction at 30 s; in all three groups, cocaine caused cerebral vasodilation, which was delayed in the adult. Cerebral metabolic O(2) consumption increased 5 min after injection in the fetus and newborn, but not until 15 min after injection in the adult. Arterial O(2) content decreased 5 min after injection in the fetus and 15 min after injection in the adult. We speculate that clinical differences in response to cocaine injection may be explained, in part, by these developmental differences in the cerebrovascular and metabolic responses to cocaine.

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Section: Discussionmentioning

confidence: 99%

Comparison of cerebrovascular effects of intravenous cocaine injection in fetal, newborn, and adult sheep

Robinson¹,

O'Brien²,

Pane³

et al. 2000

American Journal of Physiology-Heart and Circulatory Physiology

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“…Microdialysis sampling has been applied to the study of the regional effects of pharmacologic manipulation with respect to extracellular levels of amino acids and neurotransmitter binding and release in specific regions of the brain. [65][66][67][68][69][70][71][72][73][74] Because drug mechanisms usually involve interactions among many different interrelated systems, this method is invaluable in that i t allows simultaneous measurement of analyte release and metabolism in a tissue environment under normal physiologic conditions. For example, one group of investigators used in vivo brain microdialysis in an anesthetized rat model to simultaneously measure endogenous and exogenous analytes after peripheral administration of Concentrations of monoamines and their metabolites, drug and drug metabolites, and amino acids were measured in dialysates by HPLC and detection on a series of electrodes using coulometric array technology.…”

Section: Central Nervous System Drug Transport and Pharmacologymentioning

confidence: 99%

The Use of Microdialysis in Pharmacokinetics and Pharmacodynamics

Johansen,

Newman,

Madden

1997

Pharmacotherapy

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Microdialysis is a new in vivo sampling technology applied to the study of pharmacokinetics and drug metabolism in the blood and soft tissues of living systems. A small‐diameter probe containing a dialysis membrane is implanted into tissue and perfused with a suitable fluid. Low‐molecular‐weight substances passively diffuse through the semipermeable membrane along a concentration gradient, resulting in the collection of purified dialysate samples. The advantage of this approach over blood sampling and dissection of tissues is the ability to sample blood and extracellular fluid with minimal tissue damage or alteration of fluid balance. Sampling several tissues simultaneously and continuously in animal models allows data to be obtained that more directly reflect interactions of drugs at their sites of activity and detoxification. Techniques such as this will have a tremendous impact on preclinical and clinical pharmacologic research.

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Neurologic Complications of Psychomotor Stimulant Abuse

Sanchez‐Ramos

2015

International Review of Neurobiology

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Effect of Acute Cocaine Injection on the Extracellular Level of Dopamine, Blood Flow, and Oxygen Pressure in Brain of Newborn Piglets

Cited by 7 publications

References 0 publications

Comparison of cerebrovascular effects of intravenous cocaine injection in fetal, newborn, and adult sheep

Comparison of cerebrovascular effects of intravenous cocaine injection in fetal, newborn, and adult sheep

The Use of Microdialysis in Pharmacokinetics and Pharmacodynamics

Neurologic Complications of Psychomotor Stimulant Abuse

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