Effect of acute and chronic inhaled furosemide on bronchial hyperresponsiveness in mild asthma.

Abstract

We determined whether chronic administration of furosemide aerosol would be beneficial for the treatment of asthma. First, we showed that furosemide aerosol delivered from a metered-dose inhaler (10 and 20 mg) significantly protected against sodium metabisulfite (MBS) challenge by 0.6 and 1.3 doubling dilutions respectively in 12 volunteers with mild asthma. In a double-blind cross-over study, we examined the effect of furosemide aerosol from a twice more efficient metered-dose inhaler (10 mg four times per day) inhaled over 4 wk versus placebo in 12 other asthmatic subjects. There was no significant effect of furosemide on bronchial responsiveness to methacholine or MBS. Treatment with furosemide over 1 mo did not improve bronchial hyperresponsiveness in subjects with mild asthma.

Nebulized Furosemide for the Management of Dyspnea: Does the Evidence Support Its Use?

“…Increased diuresis has only been reported in four studies in adults. 29,43,46,47 The effect of the increased diuresis has been reported to last for up to 24 hours. 29 There was a nonstatistically significant increase in diuresis in the study from Rodriguez et al 47 in the furosemide group compared to placebo.…”

Inhibitory effect of furosemide on activation of human peripheral blood polymorphonuclear leukocytes stimulated with n-formyl-methionyl-leucyl-phenylalanine

“…The weak effect of Fu following preincubation compared to incubation may explain the lack of evident asthma controlling properties [38]. From our experiments, one may conclude that some of the clinical actions of Fu that resemble the cromones may be explained by inhibition of Ca 2 + influx, ROS production and chemotaxis in/of inflammatory cells.…”

The Acute Haemodynamic Effect of Nebulised Frusemide in Stable, Advanced Heart Failure

“…These data suggest that there may be a diuretic effect of nebulised frusemide. Previous studies have reported both a diuretic effect [25][26][27][28] and no diuretic effect [26,29] The Acute Haemodynamic Effect of Nebulised Frusemide in Stable, Advanced Heart Failure pharmacokinetic data available we are unable to determine if a sufficient amount of frusemide was available systemically to produce a diuretic effect. This controversy demands pharmacokinetic studies in controlled situations to demonstrate effect.…”