Effect of acute amiodarone loading on energy requirements for biphasic ventricular defibrillation

Incidence and clinical predictors of low defibrillation safety margin at time of implantable defibrillator implantation

“…Some authors found that chronic oral amiodarone therapy had no significant effect on DFT in animal studies [18] or clinical studies [12,[19][20][21][22][23], as well as acute amiodarone loading did not change the DFT in animal studies [24]. However, other authors found that chronic oral amiodarone significantly increased DFT in animals [25][26][27] and patients [7,8,11,15,17,21,[28][29][30][31]. Also, Jung et al [32] reported that DFT significantly decreased after stopping oral amiodarone.…”

Japanese Randomized Trial for Investigation of a Combined Therapy of Amiodarone and Implantable Cardioverter Defibrillator in Patients With Ventricular Tachycardia and Fibrillation

“…[13][14][15] The Nippon ICD Plus Pharmachologic Option Necessity (NIPPON) pre-study demonstrated that the VT/VF event rate in ICD patients with class I agent adjunctive therapy was significantly higher than that in patients with amiodarone. 16 Furthermore, no fatal side-effect of amiodarone was observed in the NIPPON pre-study.…”

Sotalol as Adjunctive Therapy to Implantable Cardioverter‐Defibrillators in Heart Failure Patients

“…The DFT may be influenced by many factors, including pharmacologic therapy with commonly used agents such as amiodarone 17 and carvedilol, 18 which are known to increase the threshold. The DFT may be influenced by many factors, including pharmacologic therapy with commonly used agents such as amiodarone 17 and carvedilol, 18 which are known to increase the threshold.…”