Effect of acupuncture on lung cancer-related fatigue: study protocol for a multi-center randomized controlled trial

Wang, Zhaoqin; Li, Shanshan; Wu, Luyi; Qi, Qin; Liu, Huirong; Jin, Xiaoming; Tian, Jie; Zhang, Ming; Ma, Xiao-peng; Sun, Dong; Xu, Shi‐Hai; Wu, Huangan

doi:10.1186/s13063-019-3701-0

“…Lung cancer is a primary lung tumor with a high incidence rate among middle-aged persons and the maximum death rate in my nation; clinical data suggest that the prevalence of this illness is climbing year by year [ 1 ]. Non-small cell lung cancer and small cell lung cancer are the two most frequent types of lung cancer.…”

Section: Introductionmentioning

confidence: 99%

To Explore the Effects of Acupuncture and Medical Treatment at Different Times on the Gastrointestinal Reaction and White Blood Cell Count of Patients with Lung Cancer Chemotherapy

Du

¹

,

Liu

²

,

Hua

³

et al. 2022

Applied Bionics and Biomechanics

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Objective. To explore and analyze the effects of acupuncture and medical treatment at different times on the gastrointestinal reaction and leukocyte count of patients with lung cancer undergoing chemotherapy. Methods. Select 224 lung cancer chemotherapy patients admitted to our hospital and randomly divide them into three groups: control group ( n = 76 ), study 1 group ( n = 78 ), and study 2 group ( n = 70 ). The control group was treated with tropisetron hydrochloride for 30 minutes before chemotherapy. Study 1 group was given tropisetron hydrochloride and acupuncture combination therapy 30 minutes before chemotherapy. Study 2 group was given tropisetron hydrochloride treatment 30 min before chemotherapy and acupuncture treatment 30 min after chemotherapy. Collect patients’ general information and compare the three groups of white blood cell count, G-CSF, GM-CSF levels, quality of life and KPS score, platelets, neutrophils, hemoglobin levels, TCM symptom scores, and the degree of digestive tract reaction. Results. The data of the control group and study groups 1 and 2 are comparable in gender, age, pathological type, etc. ( P > 0.05 ). Before treatment, the white blood cell counts of the three groups were not significantly different ( P > 0.05 ), significantly reduced after treatment, but the difference between the groups was not statistically significant ( P > 0.05 ). The levels of G-CSF and GM-CSF in the three groups were not substantially different before treatment ( P > 0.05 ). The levels of G-CSF and GM-CSF were considerably lowered in all three groups, although the drop in the study group was more significant ( P > 0.05 ) when compared to that in the control group. Before treatment, the quality of life and KPS score of the three groups were not statistically different ( P > 0.05 ). The three groups’ quality of life and KPS scores fell after treatment, with the study 1 group experiencing the greatest reduction, followed by the study 2 group and the control group. The levels of platelets, neutrophils, and hemoglobin in all three groups declined dramatically, with the most noticeable reduction in the control group, followed by study 2 and study 1. The difference between the three groups was statistically significant ( P < 0.05 ). The TCM symptom scores of the three groups showed an upward trend, but compared with those of the study 1 group and study 2 group, the TCM symptom scores of the control group increased significantly and the difference between the three groups was statistically significant ( P < 0.05 ). The effective rates of the control group, study group 1, and study group 2 were 42.11%, 82.05%, and 62.86%, respectively; compared with that of the control group, the treatment efficiency of study groups 1 and 2 was higher and the difference between the three groups was statistically significant ( P < 0.05 ). Conclusion. Tropisetron hydrochloride is an effective treatment for patients with lung cancer before chemotherapy, which can effectively improve the side effects of nausea and vomiting caused by chemotherapy, reduce the white blood cell count, and improve the quality of life of patients; it plays an important role in the improvement of prognosis.

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“…Nowadays, there has been a growing interest in managing fatigue with complementary health approaches. As a part of these approaches, Mind-Body Interventions (MBIs) have recently gained much interest in managing CRF (Gok Metin et al, 2019;Wang et al, 2019;Zetzl et al, 2019). MBIs are a variety of interventions designed to facilitate the mind's capacity to affect physical function (Astin et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Many studies reported that MBIs were effective for CRF (Gok Metin et al, 2019;Wang et al, 2019;Zetzl et al, 2019), but contradictory findings yielded at the same time (Kieviet-Stijnen et al, 2008;Chandwani et al, 2010;Moran et al, 2019). In addition, some systematic reviews, which summarized the results of the available evidence, provided heterogeneous results, which make it difficult to draw conclusions on the potential effectiveness of MBIs in CRF management (Zeng et al, 2014;Duong, et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Cancer-related fatigue: Systematic reviews and meta-analyses of mind–body intervention

Anshasi¹,

Ahmad

²

2020

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Objectives This study aimed to evaluate the methodological quality of systematic reviews and meta-analyses of mind–body interventions (MBIs) for the management of cancer-related fatigue. Methods A comprehensive search on multiple databases was conducted to identify relevant systematic reviews and meta-analyses published from January 2008 to December 2019. Two authors independently selected reviews, extracted data, and evaluated the methodological quality of included reviews using Assessing the Methodological Quality of Systematic Reviews (AMSTAR). Results Sixteen reviews published between 2010 and 2018 were eligible for inclusion. The methodological quality of the 16 included systematic reviews was moderate (score 4–7) to high (score ≥ 8) on the 11-point AMSTAR scale. The most common methodological weaknesses were the lack of a list of excluded studies (n = 15, 93.8%) and a priori protocol (n = 2,87.5%). Furthermore, most of the systematic reviews did not search the gray literature for eligible studies (n = 13, 81.3%). Significance of the study This study has revealed the need for high methodological quality systematic reviews on the MBIs for the management of cancer-related fatigue. Thus, further research should focus on methodologically strong systematic reviews by providing a priori design, not limiting the publication type, and providing an excluded primary studies list. Additionally, the researchers should conduct systematic reviews according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline.

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“…In China, acupuncture is a traditional treatment that has been in use for more than two millennia ( 23 ). The application of acupuncture has recently witnessed a revival in cancer-related clinical research, where acupuncture is mainly used for cancer-related pain ( 24 , 25 ), insomnia ( 26 ), psychological symptoms ( 27 ), fatigue ( 28 ), hot flashes ( 29 ), chemotherapy-induced peripheral neuropathy ( 30 ), breast cancer-related lymphedema ( 31 ), dyspnea in lung cancer ( 32 ), radiation-induced xerostomia ( 33 ) and other symptoms related to cancer. With regard to bowel function, acupuncture has shown potential in terms of ameliorating postoperative ileus ( 34 ) and gastroparesis syndrome in patients who undergo abdominal surgery ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of electroacupuncture on chemotherapy-induced diarrhea: study protocol for a randomized controlled trial

Wang¹,

Zhou²,

Shen³

et al. 2021

Transl Cancer Res TCR

1

0

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Background: Chemotherapy-induced diarrhea (CID) is one of the side effects of chemotherapy. Diarrhea not only affects the overall treatment effectiveness but also reduces patients' quality of life. Severe diarrhea can lead to electrolyte imbalance and even be life-threatening. Although acupuncture has been widely used in clinical practice and its effectiveness for managing functional diarrhea has been recognized, there is no sound evidence of its efficacy in managing CID. Therefore, the aim of the proposed randomized controlled trial is to examine the effectiveness and potential risks of using acupuncture for the management of CID and to describe its protocol herein.Methods: This trial will be conducted in a double-blinded manner and comprise two arms that will be investigated across multiple centers in parallel. The study cohort will comprise 168 outpatients who have CID from six Chinese hospitals. The patients will be randomly and equally divided between an intervention group (electroacupuncture) and a control group (micro-electroacupuncture). In the former, acupuncture will be performed with the conventional method to induce the de qi sensation, and in the latter group, acupuncture will be performed with a sham procedure that does not involve the insertion of needles.The acupoints ST25, SP14, SP6, and ST37 will be applied in the two methods. These procedures will be performed three times a week for four consecutive weeks. The number of days on which CID occurred, the incidence of CID, and fecal characteristics are considered as the primary outcomes, and the Functional Assessment of Chronic Illness Therapy for Patients with Diarrhea subscale score and the World Health Organization Quality of Life assessment are considered as secondary outcomes. The patients will be closely observed for complications and fluctuations in vital signs.Discussion: If the findings from the trial demonstrate the effectiveness and safety of using acupuncture to treat CID, they could serve as evidence for the clinical application of acupuncture as a complementary treatment for cancer patients during chemotherapy.

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Effect of acupuncture on lung cancer-related fatigue: study protocol for a multi-center randomized controlled trial

Cited by 11 publications

References 33 publications

To Explore the Effects of Acupuncture and Medical Treatment at Different Times on the Gastrointestinal Reaction and White Blood Cell Count of Patients with Lung Cancer Chemotherapy

To Explore the Effects of Acupuncture and Medical Treatment at Different Times on the Gastrointestinal Reaction and White Blood Cell Count of Patients with Lung Cancer Chemotherapy

Cancer-related fatigue: Systematic reviews and meta-analyses of mind–body intervention

Effect of electroacupuncture on chemotherapy-induced diarrhea: study protocol for a randomized controlled trial

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