Effect of acupuncture on hippocampal mitochondrial proteome expression in SAMP8 mouse model with Alzheimer disease

Ma, Liang; Li, Guangcheng; Zhu, Hong; Gong, Qiong; Dong, Keli; Long, Cong; Li, Ya-yue; Sayrash, Jiengisnur

doi:10.1007/s11726-018-1026-2

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…Acupuncture intervention in SAMP8 mice significantly upregulated the expression of mitochondria-related proteins [ 51 ]. Liang et al [ 52 ] found that DEPs were involved in the regulation of mitochondrial function as well as structure after proteomic analysis. One of them, NFL, was one of the biomarkers of neurodegeneration and was closely associated with cognitive dysfunction [ 53 ].…”

Section: Application Of Proteomics In Acupuncture Researchmentioning

confidence: 99%

Proteomics and its application in the research of acupuncture: An updated review

Zhong,

Sun,

et al. 2024

Heliyon

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Section: Application Of Proteomics In Acupuncture Researchmentioning

confidence: 99%

Proteomics and its application in the research of acupuncture: An updated review

Zhong,

Sun,

et al. 2024

Heliyon

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“…Researches show that mitochondrial damage and dysfunction are the early pathological changes of AD and precede the development of Aβ and tau pathology [96]. MA at GV20, SP10, BL23 and Geshu (BL17) can affect the hippocampal mitochondrial proteome expression to regulate the structure and function of hippocampus mitochondria in SAMP8 mice, therefore realizing the potential therapeutic effect on AD [97]. Studies have con rmed that the accumulation of oligomeric Aβ in neurons can cause increased mitochondrial ssion and reduced fusion, thus ultimately leads to neurodegeneration [98].…”

Section: Brain Energy Metabolismmentioning

confidence: 99%

The Effectiveness and Mechanisms of Acupuncture in Treating Alzheimer's Disease

Kang

Zhao

et al. 2023

Preprint

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Alzheimer's disease (AD), which mainly manifested by cognitive decline, affects millions of elderly people around the world. With the global aging continues to accelerate, the incidence of AD is also increasing year by year. The chronic, persistent, and irreversible decline of learning and memory ability of AD brings serious harm and economic burden to families and society. Because of its complex of pathogenesis, there is still a lack of effective treatment for AD. Acupuncture, as one of the complementary and alternative therapies, has provided a promising avenue for the treatment of AD. This study comprehensively reviews literature from the last ten years, showing that acupuncture indeed exerts strong beneficial effects on AD. Acupuncture can regulate the species and structure of the intestinal flora, repair the intestinal barrier and the brain blood barrier, prevent inflammatory cytokines and harmful substances in the intestine from entering the blood and brain to improve the cognitive impairment of AD. In addition to this, acupuncture can treat AD by regulating Aβ deposition (including inhibiting Aβ production and promoting Aβ clearance), inhibiting tau protein phosphorylation, improving the structure and function of neurons and synapses, promoting nerve regeneration, relieving chronic neuroinflammation, regulating energy metabolism and cerebral blood flow of the brain, etc. It is worth noting that the effect of acupuncture on AD is related to the selections of acupoints, the form and frequency of acupuncture, etc. Some special acupuncture methods, such as Sanjiao acupuncture and "olfactory three-needle" therapy, also provide new perspectives for AD. The therapeutic effect and potential mechanism of acupuncture on AD summarized in this study provide scientific and reliable evidence for acupuncture application for AD.

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Acupuncture Treatment for Alzheimer’s Disease

Pei

2022

Advanced Acupuncture Research: From Bench to Bedside

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Effect of acupuncture on hippocampal mitochondrial proteome expression in SAMP8 mouse model with Alzheimer disease

Cited by 3 publications

References 22 publications

Proteomics and its application in the research of acupuncture: An updated review

Proteomics and its application in the research of acupuncture: An updated review

The Effectiveness and Mechanisms of Acupuncture in Treating Alzheimer's Disease

Acupuncture Treatment for Alzheimer’s Disease

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