Effect of acupuncture at ST36 on motor cortical excitation and inhibition

Sun, Zhongguang; Pi, Yanling; Zhang, Jian; Wang, Miao; Zou, Jun; Wu, Wei

doi:10.1002/brb3.1370

Cited by 47 publications

(43 citation statements)

References 33 publications

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“…Therefore, acupuncture at PC6 can produce a protective cardiovascular effect and increase gastric motility related to the inhibition of GABA. Acupuncture at ST36 during the remaining needle phase can increase motor cortical excitation and reduce motor cortical inhibition through transcranial magnetic stimulation 9 . A transcriptomic analysis in mice revealed that EA at ST36 involves the GABAergic neurotransmission network of the brain 10 .…”

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confidence: 99%

Electroacupuncture at Zusanli and at Neiguan characterized point specificity in the brain by metabolomic analysis

Lee

Jiu

Hsieh

2020

Sci Rep

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Different point stimulations can induce brain activity in specific regions, and however whether these stimulations affect unique neurotransmitter transmission remains unknown. Therefore, we aimed to investigate the effect of point specificity to the brain by resolving the metabolite profiles. Eighteen Sprague-Dawley rats were randomly divided into three groups: (1) the sham group: sham acupuncture at Zusanli (ST36) without electric stimulation; (2) the Zusanli (ST36) group: electroacupuncture (EA) at ST36; and (3) the Neiguan (PC6) group: EA at PC6. Then, the metabolites from rat brain samples were measured by LC-ESI-MS. The results of a partial least squares discriminant analysis revealed the differences among the sham, ST36, and PC6 groups regarding the relative content of metabolites in the cerebral cortex, hippocampus, and hypothalamus. EA at PC6 resulted in downregulation of adenosine, adrenaline, γ-aminobutyric acid, glycine, and glutamate majorly in hippocampus, and then in cerebral cortex. Otherwise, EA at ST6 resulted in upregulation of adrenaline and arginine in hippocampus, and all stimulations showed barely change of identified neurotransmitters in hypothalamus. These differential metabolite and neurotransmitter profiles prove that brain areas can be modulated by point specificity and may provide a maneuver to understand more details of meridian. Acupuncture stimulation can affect brain activity, including the somatosensory system, motor area, and limbic system; additionally, it can modulate the activity of specific brain areas. Hence, different points produce different effects, which is a phenomenon referred to as point specificity 1. Different points on the same meridian produce brain activity in similar area. For instance, acupuncture at the liver meridian Taichong (LR3) and Zhongdu (LR6) induces activity in the ipsilateral superior parietal lobe 2. Acupuncture at adjacent points LR3 and Neiting (ST44) at different meridians induces distinct cerebral activation patterns, and this accounts for the mechanism of point specific therapeutic effects 3. Overall, acupoints are specific to induce certain downstream modulation. A possible mechanism of acupuncture is the regulation of dopamine release to affect other neurotransmitters such as γ-aminobutyric acid (GABA), glutamate, serotonin, and opioids, which contribute to the balance of the central nervous system (CNS) 4. Acupuncture facilitated synaptic dopamine release in a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease 5. Acupuncture, including manual acupuncture, electroacupuncture (EA), transcutaneous electrical nerve stimulation, and laser stimulation at PC6, can reduce the incidence of postoperative nausea and vomiting, which is a similar effect to that observed from the use of antiemetics 6. Acupuncture at PC6 modulates activity in the cardiovascular system by influencing the brain to secrete inhibitory neurotransmitters such as GABA, opioids, and 5-hydroxytryptamine to attenuate the activity of sympathetic n...

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confidence: 99%

Electroacupuncture at Zusanli and at Neiguan characterized point specificity in the brain by metabolomic analysis

Lee

Jiu

Hsieh

2020

Sci Rep

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“…It was reported in a study that stimulation of ST 36 with using anatomical tracers revealed that there is a specific relationship and connection between the central nervous system (CNS) and the ST 36. Additionally, it was demonstrated that acupuncture therapy at ST36 alleviated pain, reduced gastric dysrhythmia, and improved stomach emptying, which were mainly mediated by the neuro-transmitters pathways and opioids pathways [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of laser acupuncture tele-therapy for rheumatoid arthritis elderly patients

Adly

et al. 2021

Lasers Med Sci

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Rheumatoid arthritis (RA) is a progressive common autoimmune disorder and is one of the most functional limiting diseases in elderly. Until recently, its treatment is mainly based on physical locations and meetings while being face to face. However, laser acupuncture tele-therapy approaches can significantly provide the patient with safety during the COVID-19 pandemic as well as changing the disorder’s prognosis. Sixty patients were assigned randomly into 2 groups with 1:1 ratio. Patients in group A are treated remotely by laser acupuncture in addition to methotrexate and a tele-rehabilitation program in the form of aerobic exercise training. Patients in group B are treated by methotrexate and a tele-rehabilitation program in the form of aerobic exercise. There was a statistically significant difference in health assessment questionnaire (HAQ) pre- and post-treatment in group A ( p < 0.05). The C-reactive protein (CRP) and interleukin-6 (IL-6) inflammatory markers as well as the malondialdehyde (MDA) oxidative marker showed a significant reduction pre- and post-treatment in group A ( p < 0.05). Additionally, there was a significant increase in the adenosine tri-phosphate (ATP) antioxidant marker pre- and post-treatment in group A ( p < 0.05). The comparison between groups A and B showed a statistically significant post-treatment difference in RAQoL, CRP, IL-6, ATP, and MDA in group A than group B. Considering the significant improvement that was found in the laser acupuncture group, it can be concluded that the use of laser acupuncture as adjunctive was effective in the treatment of elderly patients with RA. ClinicalTrials.gov Identifier: NCT04758689

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“… 41 In addition, Zusanli, a main acupoint of the “stomach meridian,” has been reported to promote recovery from neurologic diseases. 42 In our previous study, we reported that EA pretreatment with Hegu, Neiguan, and Zusanli significantly alleviated postoperative cognitive decline in geriatric patients with silent lacunar infarctions 15 and in patients following spine surgery. 43 In the current study, we found that EA pretreatment with Hegu, Neiguan, and Zusanli in aged rats also significantly increased crossing platform times in the Morris maze test and elevated the time with a novel object in a model of tibial fracture surgery.…”

Section: Discussionmentioning

confidence: 87%

Electroacupuncture Pretreatment Ameliorates Anesthesia and Surgery-Induced Cognitive Dysfunction via Activation of an α7-nAChR Signal in Aged Rats

Wang¹,

Liu²,

Yin³

et al. 2021

NDT

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Objective Postoperative cognitive dysfunction (POCD) after anesthesia and surgery (AS) is a common complication in the elderly population. A cholinergic-dependent signal, the alpha7-nicotinic acetylcholine receptor (α7-nAChR), has been suggested to regulate cognitive processes in a variety of neurologic diseases. In the current study, we determined whether electroacupuncture (EA) pretreatment ameliorates AS-induced POCD in aged rats, as well as the underlying mechanism. Methods Male Sprague-Dawley rats (20 months old) were randomly assigned to the following 5 groups (n=12): vehicle; POCD (tibial fracture surgery); EA plus POCD; EA plus POCD and alpha-bungarotoxin (α-BGT); and POCD plus α-BGT groups. Alpha-bungarotoxin (1 μg/kg), a selective antagonist of α7-nAChR, was administrated via intraperitoneal injection before EA. Thirty days post-AS, the Morris water maze and a novel objective recognition test were used to evaluate cognitive function. Neuronal amount, apoptosis, microglial activation, percentage of high mobility group box 1 (HMGB1)- and nuclear factor-κB (NF-κB)-positive microglia, and levels of HMGB-1 downstream factors, including NF-κB, interleukin-6 (IL-6), and IL-1β, were detected by Nissl staining, immunofluorescence, and Western blot assays. Results EA pretreatment significantly increased crossing platform times and elevated the time with a novel object, restored the quantity of neurons, decreased TUNEL-positive neurons, alleviated activation of microglia, downregulated expression of HMGB1 and NF-κB in the microglia, and reduced levels of phosphor-NF-κB, IL-6, and IL-1β 35 days after AS, while α-BGT partially reversed these changes. Conclusion EA pretreatment improved AS-induced POCD in aged rats, and the underlying mechanism may be associated with inhibition of HMGB1–NF-κB via an α7-nAChR signal in the microglia.

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Effect of acupuncture at ST36 on motor cortical excitation and inhibition

Cited by 47 publications

References 33 publications

Electroacupuncture at Zusanli and at Neiguan characterized point specificity in the brain by metabolomic analysis

Electroacupuncture at Zusanli and at Neiguan characterized point specificity in the brain by metabolomic analysis

Effects of laser acupuncture tele-therapy for rheumatoid arthritis elderly patients

Electroacupuncture Pretreatment Ameliorates Anesthesia and Surgery-Induced Cognitive Dysfunction via Activation of an α7-nAChR Signal in Aged Rats

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