Effect of actual long-term spaceflight on BDNF, TrkB, p75, BAX and BCL-XL genes expression in mouse brain regions

Науменко, В. С.; Куликов, А. В.; Кондаурова, Е. М.; Цыбко, А. С.; Kulikova, Elizabeth A.; Краснов, И. Б.; Shenkman, Louis; Sychev, Vladimir; Bazhenova, Ekaterina; Sinyakova, N. A.; Попова, Н. К.

doi:10.1016/j.neuroscience.2014.10.045

Cited by 42 publications

(32 citation statements)

References 52 publications

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“…It was reported that one-month spaceflight did not change BDNF gene expression in the brain regions including the frontal cortex, visual cortex, caudate putamen, hippocampus, hypothalamus and midbrain raphe nuclei [16]. The effects on 5-HT1AR, 5-HT2AR and 5-HT3R were also examined in the same spaceflight, and it was reported that the spaceflight decreased 5-HT2AR gene expression in the hypothalamus without any significant effects on the expression of 5-HT1AR, 5-HT2AR and 5-HT3R in other brain regions [17].…”

Section: Discussionmentioning

confidence: 99%

“…However, the molecular mechanisms underlying the effects of gravity changes on behavior have not been extensively investigated [11–15]. Recently, spaceflight experiments using the Russian biosatellite Bion M1 reported that one-month of spaceflight affected gene expression of several trophic factors and monoaminergic systems in selected mouse brain regions [16–18]. For example, the expression of glial cell line-derived neurotrophic factor was reduced in the striatum and hypothalamus, while increased in the frontal cortex by the spaceflight [18].…”

Section: Introductionmentioning

confidence: 99%

“…For example, the expression of glial cell line-derived neurotrophic factor was reduced in the striatum and hypothalamus, while increased in the frontal cortex by the spaceflight [18]. The expression of brain-derived neurotrophic factor (BDNF) was not affected in the same condition [16]. Among monoaminergic systems, the expression of serotonin 2A receptor (5-HT2AR) and dopamine D1 receptor was reduced in the hypothalamus [17].…”

Section: Introductionmentioning

confidence: 99%

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Effects of gravity changes on gene expression of BDNF and serotonin receptors in the mouse brain

Ishikawa

Ogura

et al. 2017

PLoS ONE

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Spaceflight entails various stressful environmental factors including microgravity. The effects of gravity changes have been studied extensively on skeletal, muscular, cardiovascular, immune and vestibular systems, but those on the nervous system are not well studied. The alteration of gravity in ground-based animal experiments is one of the approaches taken to address this issue. Here we investigated the effects of centrifugation-induced gravity changes on gene expression of brain-derived neurotrophic factor (BDNF) and serotonin receptors (5-HTRs) in the mouse brain. Exposure to 2g hypergravity for 14 days showed differential modulation of gene expression depending on regions of the brain. BDNF expression was decreased in the ventral hippocampus and hypothalamus, whereas increased in the cerebellum. 5-HT1BR expression was decreased in the cerebellum, whereas increased in the ventral hippocampus and caudate putamen. In contrast, hypergravity did not affect gene expression of 5-HT1AR, 5-HT2AR, 5-HT2CR, 5-HT4R and 5-HT7R. In addition to hypergravity, decelerating gravity change from 2g hypergravity to 1g normal gravity affected gene expression of BDNF, 5-HT1AR, 5-HT1BR, and 5-HT2AR in various regions of the brain. We also examined involvement of the vestibular organ in the effects of hypergravity. Surgical lesions of the inner ear’s vestibular organ removed the effects induced by hypergravity on gene expression, which suggests that the effects of hypergravity are mediated through the vestibular organ. In summary, we showed that gravity changes induced differential modulation of gene expression of BDNF and 5-HTRs (5-HT1AR, 5-HT1BR and 5-HT2AR) in some brain regions. The modulation of gene expression may constitute molecular bases that underlie behavioral alteration induced by gravity changes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of gravity changes on gene expression of BDNF and serotonin receptors in the mouse brain

Ishikawa

Ogura

et al. 2017

PLoS ONE

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“…A number of studies in mice [30][31][32] suggest attenuation of neurotrophic factors associated with neurotransmission, it remains unclear how these changes may affect alteration in behavior and how such changes may translate into humans. It is essential to develop a deeper understanding on the potential for attenuation of brain function given the striking effect of spaceflight on structural plasticity and changes in grey matter volume [33], some of which may be attributable to fluid shifts.…”

Section: Brain Functionmentioning

confidence: 99%

Ergonomic Challenges for Astronauts during Space Travel and the Need for Space Medicine

Braddock¹

2017

J Ergonomics

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“…Although hindlimb suspension did not significantly increase the weight of the adrenal gland and plasma corticosterone level in the latter studies 44,45) , the increasing trends did not exclude the possibility that this was a false-negative result. A recent study examined whether long-term spaceflight, an extreme form of physical inactivity, affects gene expression in mouse brain, and found no significant changes in hippocampal mRNA levels of BDNF or its receptors (TrkB and p75) 48) . However, it should be noted that these mice were decapitated about 6 h after landing.…”

Section: Impacts Of Physical Inactivity On Rodent Hippocampusmentioning

confidence: 99%

Deleterious effects of physical inactivity on the hippocampus: New insight into the increasing prevalence of stress-related depression

Nishijima

Kita

2015

JPFSM

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Populations worldwide are increasingly becoming physically inactive, which is related to somatic and psychological health problems that are prevalent in modern society. Recent epidemiological studies have indicated that the associations between physical inactivity and depression are bidirectional. Numerous animal studies have demonstrated that exercise improves hippocampal function. Because the hippocampus is a pivotal brain region that exerts inhibitory control over stress responses by affecting the hypothalamus-pituitary-adrenal axis, enhanced hippocampal function by exercise can increase stress resilience, which helps prevent stress-related depression. In contrast, physical inactivity is difficult to model in animal studies, and little is known about the effects of physical inactivity on the rodent hippocampus. To fill this gap, we previously developed a mouse model of habituated voluntary wheel running cessation as a reverse intervention to control physical activity. We found that reducing physical activity by cessation of wheel running impairs hippocampal neurogenesis in mice. Thus, this review discusses the relevant literature and provides a hypothesis that physical inactivity can be a potential risk factor for stress-related depression as it increases stress vulnerability by impairing hippocampal function.

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Effect of actual long-term spaceflight on BDNF, TrkB, p75, BAX and BCL-XL genes expression in mouse brain regions

Cited by 42 publications

References 52 publications

Effects of gravity changes on gene expression of BDNF and serotonin receptors in the mouse brain

Effects of gravity changes on gene expression of BDNF and serotonin receptors in the mouse brain

Ergonomic Challenges for Astronauts during Space Travel and the Need for Space Medicine

Deleterious effects of physical inactivity on the hippocampus: New insight into the increasing prevalence of stress-related depression

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