Effect of Active and Passive Smoking on Retinal Nerve Fibre Layer and Ganglion Cell Complex

El-Shazly, Amany Abd El-Fattah; Farweez, Yousra Ahmed Thabet; Elewa, Lamia S; Elzankalony, Yasser Abdelmageuid; Farweez, Botheina Ahmed Thabet

doi:10.1155/2017/6354025

Cited by 29 publications

(13 citation statements)

References 25 publications

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“…Potential biologic explanations could be reduced axonal flow or axonal swelling in the course of axonal degeneration due to intake of neurotoxins and cytotoxins from cigarette smoke. However, our results are in contrast with findings of earlier studies 27,28 , which reported reduced pRNFLT in smokers. Suggested mechanisms leading to decreased pRNFLT were toxic damage through free radicals, increased IOP and reduced perfusion [27][28][29] .…”

Section: Discussioncontrasting

confidence: 99%

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

et al. 2018

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Section: Discussioncontrasting

confidence: 99%

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

et al. 2018

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“…23 In the present study, PERG-P50 amplitude and latency did not show significant differences between both groups, while PERG-N95 demonstrated statistically significant differences between the smokers and control groups. These results are comparable to studies by El-Shazly et al, 22 Gűndogân et al 24 and Holder 25 which reported that smoking affects PERG amplitude and latency significantly in heavy smokers compared with non-smokers. We also found significant reduction of phNR amplitude and prolonged latency in heavy smokers compared with control group.PERG-N95 and phNR are objective tests for ganglion cell functions.…”

Section: Figuresupporting

confidence: 90%

“…Although El-Shazly et al 22 concluded that total RNFL and GCC were not significantly influenced when they compared active and passive smokers, the sub-analysis of the quadrants showed that superior and inferior quadrants of RNFL were thinner in the active smokers than passive smokers, with no change in temporal or nasal quadrants. These findings were fairly similar to our results.…”

Section: Figurementioning

confidence: 90%

<p>Functional and Structural Changes of the Retinal Nerve Fiber Layer and Ganglion Cell Complex in Heavy Smokers</p>

Abdelshafy¹,

Abdelshafy²

2020

OPTH

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Purpose: To assess the functional and structural changes in the retinal nerve fiber layer (RNFL) and the ganglion cell complex (GCC) in heavy smokers using pattern electroretinogram (PERG), photopic negative response(PhNR) and spectral domain optical coherence tomography (SD-OCT). Patients and Methods: Sixty eyes of 30 heavy smokers (at least 15 cigarettes/day for 10 years) (study group) and 60 eyes of 30 age and gender-matched healthy non-smoker subjects (control group) were included. After full ophthalmologic examination (PERG), (PhNR) using RETI-port/scan 21 (Roland Consult, Brandenburg, Germany) and (SD-OCT using Topcon 3D OCT model 2000 FA version.8.30) were tested for all participants. Statistical analysis was performed to compare GCC, RNFL thicknesses, PERG and phNR values between groups. Results: The mean age was 36.67±4.13 years in the study group and 36.0±4.76 years in the control group. There were no statistical significant differences between the two groups regarding intraocular pressure (p=0.43), axial length (p=0.37), and central corneal thickness (p=0.86). There were significant differences of GCC thickness values between the study group (88.4±6.6 µm) and control group (94.83±5.25 µm) (p<0.001). The mean RNFL values of study and control groups were 97.87±5.88 and 106.43±6.59 µm, respectively (p<0.001). In the study group the superior and inferior quadrants of RNFL were significantly thinner, but there were no significant differences between the two groups in nasal and temporal quadrants. There were no significant differences of PERG-P50 amplitude (p=0.49) and latency (p=0.71); however, PERG-N95 amplitude and latency showed significant differences between the two groups (p<0.001).There were significant differences of phNR amplitude and latency between the two groups (p<0.001). Multiple regression analyses demonstrated that the PhNR, PERG amplitude and latency are the most important determinants for both RNFL and GCC thicknesses. Conclusion: In heavy smokers RNFL thickness was decreased, the PhNR, PERG-N95 amplitudes were diminished and the implicit times were prolonged compared to non-smokers. PhNR and PERG reflect both dysfunction and loss of ganglion cells and their axons.

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“…Dizygotic (DZ) twins were pooled with siblings because the genetic sharing within DZ twin pairs is similar to the genetic sharing between siblings, and the number of DZ twin pairs was too small to be separated 19 . While estimating ICCs, age, sex, axial length, presence of diabetes, and hypertension, and smoking history were adjusted as they may influence macular thickness [33][34][35][36][37] .…”

Section: Statistical Analysesmentioning

confidence: 99%

Heritability of Inner Retinal Layer and Outer Retinal Layer Thickness: The Healthy Twin Study

Kong

Hwang

et al. 2020

Sci Rep

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the purpose of the study is to evaluate the heritability of inner retinal layer (iRL) and outer retinal layer (ORL) thicknesses in the healthy Korean population. This was a cross-sectional, twin and family study. We included 374 Korean adults with healthy eyes from 89 families. IRL thickness (from the internal limiting membrane to the external limiting membrane) and oRL thickness (from the external limiting membrane to the outer border of the retinal pigment epithelium layer) were measured in the nine macular subfields as defined by the Early Treatment of Diabetic Retinopathy Study using optical coherence tomography. the heritability on iRL and oRL thicknesses were investigated using a variance decomposition model. The heritability of IRL thickness was 0.87, 0.58, 0.85, 0.89, and 0.74 for the central, inner superior, inner inferior, inner temporal, inner nasal subfields, respectively; and 0.62, 0.83, 0.62, and 0.60 for the outer superior, outer inferior, outer temporal, outer nasal subfields, respectively. The heritability of ORL thickness was 0.56, 0.75, 0.66, 0.72, and 0.56 for the central, inner superior, inner inferior, inner temporal, inner nasal subfields, respectively; and 0.64, 0.63, 0.73, 0.54 for the outer superior, outer inferior, outer temporal, and outer nasal subfields, respectively. The heritability estimates of iRL thickness and oRL thickness ranged from moderate to high. the iRL thickness at the central, inner temporal, and inner inferior subfields had particularly high heritability.

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Effect of Active and Passive Smoking on Retinal Nerve Fibre Layer and Ganglion Cell Complex

Cited by 29 publications

References 25 publications

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

<p>Functional and Structural Changes of the Retinal Nerve Fiber Layer and Ganglion Cell Complex in Heavy Smokers</p>

Heritability of Inner Retinal Layer and Outer Retinal Layer Thickness: The Healthy Twin Study

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