Effect of Acrocomia aculeata Kernel Oil on Adiposity in Type 2 Diabetic Rats

Nunes, Ângela Alves; Buccini, Danieli Fernanda; Jaques, Jeandre A.; Portugal, Luciane Candeloro; Guimarães, Rita Ca; Favaro, S. P.; Caldas, Ruy A.; Carvalho, Cristiano Marcelo Espínola

doi:10.1007/s11130-017-0648-8

Cited by 26 publications

(26 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The aqueous extract of A. aculeata (EA-Aa) is mainly composed by phenolic compounds and flavonoids, which are probably involved in the therapeutic effects of the extract. Similar data have already been described for the fruit pulp [ 23 ] and kernel of A. aculeata [ 24 , 25 , 26 ]. Plants of the same family, Arecaceae, have similar composition as EA-Aa, namely caffeic acid, rutin and quercetin [ 27 , 28 , 29 , 30 ].…”

Section: Discussionsupporting

confidence: 81%

Hypoglycaemic and Antioxidant Properties of Acrocomia aculeata (Jacq.) Lodd Ex Mart. Extract Are Associated with Better Vascular Function of Type 2 Diabetic Rats

et al. 2021

View full text Add to dashboard Cite

Oxidative stress is involved in the metabolic dysregulation of type 2 diabetes (DM2). Acrocomia aculeata (Aa) fruit pulp has been described for the treatment of several diseases, and recently we have proved that its leaves have phenolic compounds with a marked antioxidant effect. We aimed to assess whether they can improve metabolic, redox and vascular functions in DM2. Control Wistar (W-Ctrl) and non-obese type 2 diabetic Goto–Kakizaki (GK-Ctrl) rats were treated for 30 days with 200 mg.kg−1 aqueous extract of Aa (EA-Aa) (Wistar, W-EA-Aa/GK, GK-EA-Aa). EA-Aa was able to reduce fasting glycaemia and triglycerides of GK-EA-Aa by improving proteins related to glucose and lipid metabolism, such as GLUT-4, PPARγ, AMPK, and IR, when compared to GK-Ctrl. It also improved viability of 3T3-L1 pre-adipocytes exposed by H2O2. EA-Aa also increased the levels of catalase in the aorta and kidney, reduced oxidative stress and increased relaxation of the aorta in GK-treated rats in relation to GK-Ctrl, in addition to the protective effect against oxidative stress in HMVec-D cells. We proved the direct antioxidant potential of the chemical compounds of EA-Aa, the increase in antioxidant defences in a tissue-specific manner and hypoglycaemic properties, improving vascular function in type 2 diabetes. EA-Aa and its constituents may have a therapeutic potential for the treatment of DM2 complications.

show abstract

Section: Discussionsupporting

confidence: 81%

Hypoglycaemic and Antioxidant Properties of Acrocomia aculeata (Jacq.) Lodd Ex Mart. Extract Are Associated with Better Vascular Function of Type 2 Diabetic Rats

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Furthermore, Nunes et al demonstrated that experimental diabetic animals presented a reduction of glycemic levels when treated with Bocaiuva (Acrocomia sp.) oil, 39 which corroborates our results.…”

supporting

confidence: 91%

High-Protein Diet Associated with Bocaiuva Supplementation Decreases Body Fat and Improves Glucose Tolerance in Resistance-Trained Rats

Almeida

Santana

Motta‐Santos

et al. 2020

Journal of Medicinal Food

View full text Add to dashboard Cite

High-protein diets (HPDs) are widely used for health and performance. However, the combination of whey protein and natural foods (i.e., fruits) is still unclear. Thus, we evaluated the role of supplemental HPD with Bocaiuva (Acrocomia sp.) in metabolic and body composition parameters of rats submitted to resistance training (RT). Wistar rats (203.3 -30 g) were randomly allocated to five groups: normoproteic control (CON, n = 5), sedentary high-protein (SH, n = 5), RT + H (trained high-protein [TH], n = 5), sedentary+Bocaiuva (SH+B, n = 4), and RT+Bocaiuva (TH+B, n = 4) diet groups. After 12 weeks of RT, the maximal strength increased in both trained groups (P < .05). The TH + B group had lower values of adiposity index (AI) (3.8 -0.7% vs. 6.8 -1.3%) and visceral fat (0.038 -0.004 g/g vs. 0.067 -0.012 g/g) compared with the SH group, respectively (P < .05). The other groups did not show differences in values of AI (CON, 5.4 -1.6%, TH, 5.4 -1.3%, and SH+B, 5.5 -1.2%). In addition, the fasting glucose of trained groups (TH, 106.0 -4.5, and TH+B, 100.4 -13.5 dL/mg) was significantly lower when compared with controls (SH, 120.0 -14.4, and SH+B, 119 -6.4 dL/mg) (P < .05). Bocaiuva combined with an HPD reduced visceral fat and AI in addition to improving glucose tolerance of rats submitted to RT.

show abstract

“…So, the nematode survival was improved, by the prevention of Juglone-induced oxidative damage [66]. A. aculeata fruit pulp and kernel have shown similar results, in particular the in vitro antioxidant activity and absence of cytotoxicity [67], besides hypoglycemic [68] and anti-inflammatory and diuretic effects [69].…”

mentioning

confidence: 96%

Acrocomia aculeata(Jacq.) Lodd. ex Mart. Leaves Increase SIRT1 Levels and Improve Stress Resistance

Alfredo

Matafome

Iacia

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Oxidative stress is a metabolic disorder linked with several chronic diseases, and this condition can be improved by natural antioxidants. The fruit pulp of the palm Acrocomia aculeata (Jacq.) Lodd. ex Mart. is widely used in the treatment of various illnesses, but as far as we know, there are no reports regarding the properties of its leaves. Thus, we aimed to evaluate the antioxidant activity of A. aculeata leaf extracts obtained with water (EA-Aa), ethanol (EE-Aa), and methanol (EM-Aa) solvents. The extracts were chemically characterized, and their antioxidant activity was assessed through the scavenging of the free radicals DPPH and ABTS. EE-Aa and EM-Aa showed the highest amounts of phenolic compounds and free radical scavenging activity. However, EA-Aa was more efficient to protect human erythrocytes against AAPH-induced hemolysis and lipid peroxidation. Thus, we further show the antioxidant effect of EA-Aa in preventing AAPH-induced protein oxidation, H2O2-induced DNA fragmentation, and ROS generation in Cos-7 cells. Increased levels of Sirt1, catalase, and activation of ERK and Nrf2 were observed in Cos-7 treated with EA-Aa. We also verify increased survival in nematodes C. elegans, when induced to the oxidative condition by Juglone. Therefore, our results showed a typical chemical composition of plants for all extracts, but the diversity of compounds presented in EA-Aa is involved in the lower toxicity and antioxidant properties provided to the macromolecules tested, proteins, DNA, and lipids. This protective effect also proven in Cos-7 and in C. elegans was probably due to the activation of the Sirt1/Nrf2 pathway. Altogether, the low toxicity and the antioxidant properties of EA-Aa showed in all the experimental models support its further use in the treatment of oxidative stress-related diseases.

show abstract

Effect of Acrocomia aculeata Kernel Oil on Adiposity in Type 2 Diabetic Rats

Cited by 26 publications

References 22 publications

Hypoglycaemic and Antioxidant Properties of Acrocomia aculeata (Jacq.) Lodd Ex Mart. Extract Are Associated with Better Vascular Function of Type 2 Diabetic Rats

Hypoglycaemic and Antioxidant Properties of Acrocomia aculeata (Jacq.) Lodd Ex Mart. Extract Are Associated with Better Vascular Function of Type 2 Diabetic Rats

High-Protein Diet Associated with Bocaiuva Supplementation Decreases Body Fat and Improves Glucose Tolerance in Resistance-Trained Rats

Acrocomia aculeata(Jacq.) Lodd. ex Mart. Leaves Increase SIRT1 Levels and Improve Stress Resistance

Contact Info

Product

Resources

About