Effect of Acetyl-&lt;i&gt;L&lt;/i&gt;-Carnitine on Serum Levels of Cortisol and Adrenocorticotropic Hormone and Its Clinical Effect in Patients with Senile Dementia of Alzheimer Type

Parnetti, Lucilla; Gaiti, Alberto; Mecocci, Patrizia; Gottfries, Carl Gerhardt; Santucci, Carla; Reboldi, Gian Paolo; Senin, Umberto

doi:10.1159/000107137

Cited by 6 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result was coincided with Laboni et al, (1987) who reported that Lcarnitine deficiency may play a major role in Na-K pump dysfunction in uremic patients. There was significant decrease in serum cortisol with L-carnitine injection which is agreed with Parnetti et al (1990).…”

Section: Discussionsupporting

confidence: 84%

Evaluation of L-carnitine in the treatment of experimentally induced hypomagnesemia in sheep

Helal

Hefnawy

Abo-Kora

et al. 2018

Benha Veterinary Medical Journal

View full text Add to dashboard Cite

The aim of this study was to evaluate the role of L-carnitine in the treatment of experimentally induced hypomagnesemia in sheep. This study was carried out on 10 ossimi rams aged 10-12 months old with an average live weight of 35±1.1 kg that were used for experimental induction of hypomagnesemia. Rams with induced hypomagnesaemia were divided into two groups according to the line of treatment. The first group (n=5) was treated by the traditional treatment alone while the second group (n=5) was treated by the traditional treatment in addition to L-carnitine (20 mg/kg I/V). The symptoms of hypomagnesemia appeared gradually until complete appearance of symptoms at day 28 post induction. There was significant decrease (P < 0.05) in serum magnesium (Mg), calcium (Ca), glucose and parathyroid hormone (PTH) in experimentally induced hypomagnesemic rams. However, there were significant increase (P < 0.05) in serum sodium (Na), potassium (K), urea, creatinine, cortisol, creatine phosphokinase (CPK) and troponin I (cTnI) in experimentally induced hypomagnesemic rams. Treatment of hypomagnesemia with traditional treatment and L-carnitine resulted in significant elevation (P < 0.05) of serum Mg, Ca, glucose and PTH in hypomagnesemic rams than traditional treatment only. However, there were significant reduction (P < 0.05) in serum K, urea, CPK and cTnI than traditional treatment only at 24 hour after treatment. Based on the results of this study we concluded that the addition of L-carnitine to the traditional treatment of hypomagnesaemia in sheep is effective and produced earlier and more pronounced recovery.

show abstract

Section: Discussionsupporting

confidence: 84%

Evaluation of L-carnitine in the treatment of experimentally induced hypomagnesemia in sheep

Helal

Hefnawy

Abo-Kora

et al. 2018

Benha Veterinary Medical Journal

View full text Add to dashboard Cite

show abstract

“…ST200 was chosen as the reference drug since consistent evidence exists about its efficacy in improving cognitive functions in SDAT (Calvani & Carta 1991;Cucinotta et al 1988;Parnetti et al 1990;Rai et al 1990). …”

Section: Discussionmentioning

confidence: 99%

Multicentre Study of l-??-Glyceryl-Phosphorylcholine vs ST200 among Patients with Probable Senile Dementia of Alzheimer??s Type

Parnetti

Abate

Bartorelli³

et al. 1993

Drugs & Aging

View full text Add to dashboard Cite

A multicentre, randomised, controlled study compared the efficacy of l-alpha-glyceryl-phosphorylcholine (alpha GPC) and ST200 (acetyl-l-carnitine) among 126 patients with probable senile dementia of Alzheimer's type (SDAT) of mild to moderate degree. Efficacy was evaluated by means of behavioural scales and psychometric tests. The results showed significant improvements in most neuropsychological parameters in the alpha GPC recipients. Improvements also occurred in the ST200 recipients but to a lesser extent. Tolerability was good in both groups. These positive findings require replication in larger, double-blind, longitudinal studies coupling clinical and biological determinations.

show abstract

“…Moreover, ALC has been shown to promote acetylcholine synthesis and induce choline acetyltransferase activity (Imperato et al, 1989). ALC has been shown to be of some benefit in the treatment of AD (Carta & Calvani, 1991;Parnetti et al, 1990;Sano et al, 1992;Spagnoli et al, 1991). Spagnoli and colleagues conducted a randomized, double-blind, placebo-controlled trial, much as described in the present study.…”

mentioning

confidence: 99%

Acetyl L-Carnitine Slows Decline in Younger Patients With Alzheimer's Disease: A Reanalysis of a Double-Blind, Placebo-Controlled Study Using the Trilinear Approach

Brooks

Yesavage

Carta

et al. 1998

Int. Psychogeriatr.

View full text Add to dashboard Cite

Objectives: To assess the longitudinal effects of acetyl-L-carnitine (ALC) on patients diagnosed with Alzheimer's disease. Design: Longitudinal, double-blind, parallel-group, placebocontrolled. Setting: Twenty-four outpatient sites across the United States. Participants: A total of 334 subjects diagnosed with probable Alzheimer's disease by NINCDS-ADRDA criteria. These data were originally reported by Thal and colleagues (1996). Measurements: Cognitive subscale of the Alzheimer Disease Assessment Scale (ADAS) given every 3 months for 1 year. Results: The average rate of change was estimated using the trilinear approach, which allows for periods of both change and stability. Both the ALC group and the placebo group exhibited the same mean rate of change on the ADAS (0.68 points/month). However, a multiple regression analysis revealed a statistically significant Age × Drug interaction characterized by younger subjects benefiting more from ALC treatment than older subjects. Further analyses suggested that the optimal, though not statistically significant, cutpoint for ALC benefit was 61 years of age. Conclusions: ALC slows the progression of Alzheimer's disease in younger subjects, and the use of the trilinear approach to estimate the average rate of change may prove valuable in pharmacological trials.

show abstract

Effect of Acetyl-<i>L</i>-Carnitine on Serum Levels of Cortisol and Adrenocorticotropic Hormone and Its Clinical Effect in Patients with Senile Dementia of Alzheimer Type

Cited by 6 publications

References 5 publications

Evaluation of L-carnitine in the treatment of experimentally induced hypomagnesemia in sheep

Evaluation of L-carnitine in the treatment of experimentally induced hypomagnesemia in sheep

Multicentre Study of l-??-Glyceryl-Phosphorylcholine vs ST200 among Patients with Probable Senile Dementia of Alzheimer??s Type

Acetyl L-Carnitine Slows Decline in Younger Patients With Alzheimer's Disease: A Reanalysis of a Double-Blind, Placebo-Controlled Study Using the Trilinear Approach

Contact Info

Product

Resources

About