Effect of ACE Inhibition on the Fibrinolytic System in Patients Requiring Coronary Artery Bypass Grafting

Walter, Thomas; Szabo, Sebastian; Kazmaier, S.; Süselbeck, Tim; Borggrefe, Martin; Hm, Hoffmeister

doi:10.1055/s-0029-1185596

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…Importantly, the current study was delineated to exclude clinical conditions and pharmacotherapeutics that may interfere on PAI-1 and D-Di levels, such as, diabetes [7,8], hormone replacement [8], use of antihypertensives [9,10], statins [11,12] and smoking [12]. Some authors have demonstrated that hypertensive patients present higher levels of PAI-1 [13,14] and D-Di [15] compared to normotensive individuals.…”

Section: Discussionmentioning

confidence: 97%

“…Some authors have demonstrated that hypertensive patients present higher levels of PAI-1 [13,14] and D-Di [15] compared to normotensive individuals. In addition, antihypertensives may decrease [9,16,17] or not interfere [10,18] on these biomarkers. Our findings demonstrate that the coexistence of hypertension did not increase the values of PAI-1 and D-Di, suggesting that obesity, mainly in morbid obeses (about 70% of our sample), by itself may be responsible by the increase of the plasma levels of these biomarkers.…”

Section: Discussionmentioning

confidence: 97%

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Negative correlation between D-dimer and plasminogen activator inhibitor-1 levels is absent in obese women

Ceo

Petruceli²,

Bosco³

et al. 2012

Blood Coagulation &Amp; Fibrinolysis

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Obesity is characterized by alterations in haemostatic processes that lead to a prothrombotic state. D-dimer (D-Di) is the last product of the fibrinolysis and may reflect the haemostatic balance. As the plasminogen activator inhibitor (PAI)-1 is the main inhibitor of fibrinolysis and it is elevated in obese, we hypothesize that negative correlation exists between PAI-1 and D-Di. In addition, we evaluated if plasma levels of PAI-1 and D-Di may be correlated with clinical parameters of adiposity [waist circumference and waist-to-hip ratio (WHR)]. We measured plasma PAI-1 and D-Di concentrations using ELISA in 60 women: 21 lean women without comorbidities and 39 obese women. We found higher levels of D-Di and PAI-1 in obese groups compared to control group (P < 0.05). No differences were observed between obese and obese untreated hypertensives. PAI-1 levels, but not of D-Di, are positively correlated with BMI (control, r = 0.44) and WHR (all obese, r = 0.40). Negative correlation was found between PAI-1 and D-Di in control (r = -0.56), no association was observed in obese, signalizing to a particular attention regarding the clinical use of D-Di. Our results indicate the magnitude of central obesity as a risk factor for development of disorders related to prothrombotic states.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Negative correlation between D-dimer and plasminogen activator inhibitor-1 levels is absent in obese women

Ceo

Petruceli²,

Bosco³

et al. 2012

Blood Coagulation &Amp; Fibrinolysis

View full text Add to dashboard Cite

show abstract

“…It is also known that ACE is involved in the regulation of fibrinolysis and platelet activation and aggregation, while the I/D polymorphism of ACE affects the fibrino gen and PAI 1 levels [30]. A high ACE level is gener ally considered a risk factor for vascular pathology, first of all, for ischemic heart disease and myocardial inf arction, as well as for IS [31,32]. However, the signif icance of the I/D polymorphism for cerebrovascular pathology is a disputed issue [12,13,33].…”

Section: Discussionmentioning

confidence: 99%

Association of polymophisms of renin-angiotensin and hemostasis system genes with ischemic stroke in Russians from central Russia

et al. 2012

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The allele and genotype frequencies of 14 SNPs of renin-angiotensin (REN, AGT, AGTR1, AGTR2, BKR2, and ADRB2) and hemostasis (FGB, F2, F5, F7, ITGB3, SERPINE1, MTHFR) system genes, as well as of the ACE insertion-deletion polymorphism, were analyzed in patients with ischemic stroke and in healthy controls matched by age, sex, and ethnicity. Genotyping was performed through the amplification of the selected gene sequences and subsequent hybridization of the labeled fragments with SNP specific DNA probes on the biochip. There were no significant differences in the allele frequencies of individual genes between the groups of stroke patients and healthy donors. The contribution of the renin-angiotensin and hemostasis system genes to the genetic susceptibility to ischemic stroke in Russians from central Russia was also assessed using the MDR (Multifactor Dimensionality Reduction) approach. The genotype combination FGB G/-x ACE I/-x MTHFR C/-x SERPINE1 5G/5G, the frequency of which was significantly higher in patients with stroke than in healthy controls, was associated with an increased risk of ischemic stroke (P = 0.03, OR = 2.4, 95%CI 1.1-5.3).

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Effects of mineralocorticoid receptor antagonists on the risk of thrombosis, bleeding and mortality: A systematic review and meta-analysis of randomized controlled trials

Elbers

Sjouke

Zannad

et al. 2016

Thrombosis Research

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Effect of ACE Inhibition on the Fibrinolytic System in Patients Requiring Coronary Artery Bypass Grafting

Abstract: Although PAI-1 activity levels are reduced after short-term treatment with ACE inhibitors in patients with stable angina pectoris while TPA antigen is unaffected, treatment with ACE inhibitors does not lead to a marked change in plasmin activation.

Cited by 3 publications

References 15 publications

Negative correlation between D-dimer and plasminogen activator inhibitor-1 levels is absent in obese women

Negative correlation between D-dimer and plasminogen activator inhibitor-1 levels is absent in obese women

Association of polymophisms of renin-angiotensin and hemostasis system genes with ischemic stroke in Russians from central Russia

Effects of mineralocorticoid receptor antagonists on the risk of thrombosis, bleeding and mortality: A systematic review and meta-analysis of randomized controlled trials

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