Effect of Abutilon indicum in thyroxine-induced hyperthyroidism in rat

Abstract

The study was designed to investigate the antithyroid activity of the crude methanolic (70%) extract of aerial parts of Abutilon indicum in male albino rats. The extract was prepared and analyzed for the presence of phytochemical constituents through preliminary chemical analysis, antioxidant assay and GC-MS. The in vivo antithyroid activities in thyroxine-induced hyperthyroidism were studied. Phytochemical analysis showed the presence of alkaloids, flavonoids and phenols, also verified by the data obtained from GC-MS. Thyroxine increased the levels of triiodothyronine (4.9 ± 0.1 ng/mL) and total thyroxine (9.4 ± 0.2 μg/dL); while, A. indicum at the doses of 300 and 500 mg/kg, showed significant decrease in the elevated levels of triiodothyronine (3.0 ± 0.1 and 2.6 ± 0.2 ng/mL) and thyroxine (7.7 ± 0.2 and 7.1 ± 0.2 μg/dL), respectively. Histopathological studies showed the restoration of filled follicular colloids in extract-treated animals. The results show that A. indicum exhibits dose-dependent antithyroid effects.

Pharmacological Role of Capparis decidua (Forssk.) Edgew in Preventing Cyclophosphamide-induced Myelosuppression and Modulating Innate and Adaptive Immune Response

“… 28 The GCMS analysis showed most important phytoconstituents including isothiocyanate which exhibit anticancer properties, 10 capric acid (decanoic acid) reported to upregulate human TNF-α, IL-1β, IL-6 and IL-8, 30 β sitosterol and phytosterol utilized for immunomodulation, 9 tocopherol famous for antioxidant and anticancer potential, lupeol downregulates proinflammatory signaling in macrophages, linoleic and palmitic acid (fatty acids) possess significant anti-inflammatory actions. 17 …”

“…28 The GCMS analysis showed most important phytoconstituents including isothiocyanate which exhibit anticancer properties, 10 capric acid (decanoic acid) reported to upregulate human TNF-α, IL-1β, IL-6 and IL-8, 30 β sitosterol and phytosterol utilized for immunomodulation, 9 tocopherol famous for antioxidant and anticancer potential, lupeol downregulates proinflammatory signaling in macrophages, linoleic and palmitic acid (fatty acids) possess significant anti-inflammatory actions. 17 The initial response of innate mechanisms is the phagocytosis of antigenic substances by neutrophils, monocytes, macrophages and mast cells. Phagocytic cells recognize the non-self substances using mannose receptors, toll like receptors, complement receptors and Fc receptors, which bind with limited molecular patterns of pathogens, complement proteins after non-selective opsonization and immunoglobulins after selective opsonization.…”

“…Identification of the constituents was carried out by comparing the spectral patterns with NIST 05 and Willey spectral library. 16 , 17 …”

Evaluation of Caralluma edulis for its Potential Against Obesity, Atherosclerosis and Hypertension

“…The antioxidant potential of CE.Cr was measured in terms of free radical scavenging or hydrogen donating ability of stable 1, 1- diphenyl 2-picrylhydrazyl (DPPH) free radical according to the protocol described by Jabeen et al with slight modifications. 22 1 mL of 0.1 mM methanolic solution of DPPH was mixed with 1 mL of each CE.Cr methanolic solution of varying concentration (50-1000 μg/ml). L-Ascorbic acid solution was used as a reference standard, and a mixture of 1 mL DPPH and 1 mL methanol was used as control.…”

Characterization of Sesuvium sesuvioides Using High-Performance Liquid Chromatography and Validation of Its In Vivo Anti-hyperthyroidism Effect via Suppressing Oxidative Stress and Inflammatory Markers

“…It has been observed that many plants that exhibit tyrosine in their constituents are considered responsible for the production of thyroid hormones [triiodothyronine (T 3 ) and T 4 ]. Plants with antihyperthyroidism potential, such as Ficus racemosa, Aloe vera, Hippophae rhamnoides, Luffa acutangula, and Abutilon indicum were previously reported.…”