Effect of abana (a herbal preparation) on the radiation-induced mortality in mice

Jagetia, Ganesh Chandra; Baliga, Manjeshwar Shrinath; Aruna, R; Rajanikant, G. K.; Jain, Vikas

doi:10.1016/s0378-8741(03)00037-0

Cited by 33 publications

(16 citation statements)

References 10 publications

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“…A decline in the effect has been observed earlier for various other extracts. 18,28,29 Earlier studies of radioprotection have shown that an agent being tested for radioprotective action acts only at a particular dose, above which it may not be protective and in some cases can even be toxic. 17,18,27,30,31 A similar action cannot be ruled out in the present study, in which optimal protection by AME at 20 mg/kg was observed while higher doses resulted in a decline in the protective action of AME.…”

Section: Discussionmentioning

confidence: 99%

“…A similar observation has also been reported for Ocimum sanctum, ginger and abana, a polyherbal formulation. 18,29,32 Plants such as O. sanctum, Moringa oleifera, Mentha arvensis, and Syzygium cumini have been reported to protect mice against radiation-induced sickness and mortality. 18,[33][34][35] Similarly, other plants such as Spirulina platensis, Allium sativum, Withania somnifera, O. sanctum, Chlorella vulgaris, Phyllanthus niruri, Panax ginseng, and Ginkgo biloba have also been reported to protect mice against radiation-induced tissue damage.…”

Section: Discussionmentioning

confidence: 99%

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Fruit Extract of Aegle marmelos Protects Mice Against Radiation-Induced Lethality

2004

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The radioprotective effect of a hydroalcoholic extracted material from the fruit of Aegle marmelos (AME) was studied in mice exposed to different doses of gamma radiation. The optimum dose for radioprotection was determined by administering 0, 5, 10, 20, 40, or 80 mg/kg body weight of AME intraperitoneally (ip) once daily, consecutively for 5 days before exposure to 10 Gy of gamma radiation. A total of 20 mg/kg of AME for 5 consecutive days before irradiation was found to afford maximum protection as evidenced by the highest number of survivors after 30 days postirradiation. Animals from all groups were monitored for 30 days postirradiation for development of symptoms of radiation sickness and mortality. Treatment of mice with AME before exposure to different doses of gamma radiation reduced the severity of symptoms of radiation sickness and mortality with all exposure doses. This was accompanied by an increase in number of survivors in the AME + irradiation group when compared with the concurrent sterile physiological saline (SPS) + irradiation group. AME pretreatment protected mice against the gastrointestinal as well as bone marrow deaths, as evidenced by the greater number of survivors on day 10 or 30, respectively. LD50/30 was found to be 8.2 Gy for the SPS + irradiation group, while it was 8.8 Gy for AME + irradiation. The dose-reduction factor (DRF) was found to be 1.1 for AME + irradiation group. The acute toxicity study of AME showed that it was nontoxic up to a dose of 6 g/kg body weight, the highest drug dose that could be administered. Irradiation of animals resulted in a dose-dependent elevation in lipid peroxidation in liver, kidney, stomach, and intestine of mice. Conversely, GSH concentration declined in a dose-dependent manner. Treatment of animals with AME before irradiation caused a significant decrease in the lipid peroxidation accompanied by a significant elevation in the GSH concentration in liver, kidney, stomach, and intestine of mice determined at 31 days postirradiation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fruit Extract of Aegle marmelos Protects Mice Against Radiation-Induced Lethality

2004

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“…In the 30-day survival test, the modulation by the agent of the recovery and regeneration of the gastrointestinal epithelium and the haematopoietic progenitor cells in the bone marrow could be evaluated, which are two of the most radiosensitive organs essential for sustenance of the life [137,138] . The gastrointestinal (GI) syndrome in mice can be assessed by determining the survival up to 10 days (measure of GI death) after exposure of the animals to comparatively high doses of IR, whereas haematopoietic syndrome can be assessed by monitoring the survival of irradiated animals up to 30 days post-IR [137,139,[140][141][142] . The intestinal crypt cell assay or functional changes also serve as indicators of GI damage [143] .…”

Section: Strategies For and Challenge Of Ra Randdmentioning

confidence: 99%

Research and Development of Radioprotective Agents: A Mini-Review

Saaya

Katsube

Xie

et al. 2017

International Journal of Radiology

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The research and development (R&D) of radioprotective agents (RAs) have been conducting since seven decades ago, and the safety and protection against undesirable effects of ionizing radiation (IR) has become an important issue especially for the benefit of patients receiving the radiotherapy, in addition to the applications in nuclear industry, military, outer space exploration and accidental exposures. Although the technology advancement makes the radiotherapy a promising better treatment by maximizing the effect of IR to the cancer cells, there are still needs for improvement in minimizing the toxicity to the normal cells. Aiming at providing the new researchers in the radiation protection field with an overall view for R&D of the RAs, this mini-review elucidates in brief a general understanding of the IR and its effects on the cell, the concepts of radiotherapy and therapeutic ratio, the categories of RAs and their mechanisms, and discusses on the strategies and challenge for R&D of the RAs.

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“…Despite the relatively high sensitivity of bone marrow stem cells to radiation, the peripheral blood cells have longer transit time than the intestinal cells. It is well-known that death within 10 days after radiation is due to GI damage and death from 11 to 30 days caused by hemopoietic damage (Jagetia et al, 2003;Patil et al, 2012). Since all mice in the 10 Gy group died before day 6 and all mice in the SAN + 10 Gy group died before day 12, GI damage is the main cause of death induced by lethal dose of 10 Gy.…”

Section: Discussionmentioning

confidence: 99%

Protection effect of sanguinarine on whole-body exposure of X radiation in BALB/c mice

Zhao

Chong

et al. 2014

Braz. J. Pharm. Sci.

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To investigate the effects of sanguinarine (SAN) on acute radiation induced injury in mice, 45 mice were randomly divided into control, 10 Gy and SAN+10 Gy groups. Mice in the 10 Gy and SAN+10 Gy groups were exposed to single X-ray radiation with an accumulated dose of 10 Gy. Mice in the SAN+10 Gy group were administered intraperitoneally with 2.5 mg/kg body weight of SAN before radiation. Five days after radiation exposure, 5 mice from each group were sacrificed and samples of the small intestine, lung, spleen and liver were fixed for histopathological examinations. Compared with the 10 Gy group, radiation sickness was obviously delayed or attenuated in the SAN+10 Gy group. Survival analysis showed a significant difference between 2 radiation groups (P<0.05) and mean survival time was 3 days longer in the SAN+10 Gy group than in the 10 Gy group (7.21±0.19 vs. 4.20±0.13, P<0.001). Radiation-induced organ damage, based on histopathological examinations, was decreased by SAN pretreatment. Chiu's pathology grading scores, which is an index of intestinal damage, was significantly lower in the SAN+10 Gy group than in the 10 Gy group (2.77±0.48 vs. 4.37±0.31, P<0.01). A similar result was obtained in the pathological score of lung (1.67±0.21 vs. 2.33±0.38, P<0.01). Our preliminary findings demonstrated that SAN protects animals against radiation-induced sickness and acute damage to organs and following animal death.Uniterms: Sanguinarine/radioprotection. X-ray/radiation/effects. Radiation sickness. Radiation/ survival analysis.Para investigar os efeitos da sanguinarina (SAN) em lesões induzidas em ratos por radiação aguda, 45 ratos foram aleatoriamente divididos em grupo controle, grupo 10 Gy e grupo SAN+10 Gy. Os ratos dos grupos 10 Gy e SAN+10 Gy foram expostos à radiação de raio-X simples com uma dose acumulada de 10 Gy. Aos ratos do grupo SAN+10 Gy administraram-se, intraperitonealmente, 2.5 mg/kg de peso de SAN antes da radiação. Aos 5 dias de exposição à radiação, sacrificaram-se 5 ratos de cada grupo e retiraram-se amostras do intestino delgado, pulmões, baço e fígado para exames histopatológicos. Comparando com o grupo 10 Gy, a doença por radiação foi claramente atrasada e atenuada no grupo SAN+10 Gy. A análise de sobrevivência mostrou diferença significativa entre os dois grupos de radiação (P<0.05) e o tempo de sobrevivência média foi de mais 3 dias no grupo SAN+10 Gy do que no grupo 10 Gy (7.21±0.19 vs 4.20±0.13, P<0.001). Danos induzidos nos órgãos por radiação, baseados em exames histopatológicos, foram reduzidos pelo pré-tratamento com SAN. As pontuações de classificação da patologia Chiu, um índice para os danos intestinais, foi significativamente menor no grupo SAN+10 Gy do que no grupo 10 Gy (2.77±0.48 vs 4.37±0.31, P<0.01). Resultado semelhante foi obtido na pontuação patológica do pulmão (1.67±0.21 vs 2.33±0.38, P<0.01). As nossas descobertas preliminares mostram que SAN protege os animais contra doenças induzidas pela radiação e danos agudos nos órgãos seguidos de morte animal.Unitermos: Sanguinari...

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Effect of abana (a herbal preparation) on the radiation-induced mortality in mice

Cited by 33 publications

References 10 publications

Fruit Extract of Aegle marmelos Protects Mice Against Radiation-Induced Lethality

Fruit Extract of Aegle marmelos Protects Mice Against Radiation-Induced Lethality

Research and Development of Radioprotective Agents: A Mini-Review

Protection effect of sanguinarine on whole-body exposure of X radiation in BALB/c mice

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