Effect of a zinc phosphate suspension of a long-acting somatostatin analog on postprandial plasma glucose, triglyceride and glucagon concentrations in alloxan diabetic dogs

Twenty inpatients suffering from diabetes mellitus were given prescribed therapeutic diets containing 1,000-1,500 kcal/day and supplemented with 28 mg zinc phosphate for 3 weeks. Twenty outpatients were untreated and were advised to consume specified diets. The results indicated good response for the inpatient group. Elevated levels for insulin and serum zinc were shown, which proved to be statistically significant. Blood glucose, glucagon, and glucose-6-phosphatase levels were reduced significantly due to the diet management and zinc supplementation, while calcium showed no difference. The control group did not show any significant difference in any parameter throughout the study. Our findings suggest that a controlled dietary regimen together with supplementation with zinc might be useful to suppress plasma glucose and to regulate insulin secretion of diabetics.

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Effect of a zinc phosphate suspension of a long-acting somatostatin analog on postprandial plasma glucose, triglyceride and glucagon concentrations in alloxan diabetic dogs

Cited by 3 publications

References 7 publications

Pharmacological studies of somatostatin and somatostatin-analogues: Therapeutic advances and perspectives

Pharmacological studies of somatostatin and somatostatin-analogues: Therapeutic advances and perspectives

6 Hypoglycaemic Agents Which Do Not Release Insulin

Effect of Zinc Supplementation on Serum Glucose, Insulin, Glucagon, Glucose-6-Phosphatase, and Mineral Levels in Diabetics.

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