Effect of a weight loss program on serum adiponectin and insulin resistance among overweight and obese premenopausal females

Abstract

Background Obesity has emerged as a public health crisis in many populations including Egypt. Adipose tissue produces a number of adipokines, one of them is adiponectin which has attracted much attention because of its antidiabetic and antiatherogenic effects. Objective To determine the effect of a weight loss program on serum adiponectin level and insulin resistance among overweight and obese adult premenopausal females. Study design A pre-postintervention study was carried out among 95 premenopausal overweight and obese females (body mass index ≥ 25 kg/m2) aged 20 to 40 years at the integrated health clinic affiliated to the High Institute of Public Health, Alexandria, Egypt, from February 2016 to February 2017. All participants underwent a weight loss program based on a reduced calorie balanced diet and advised to increase their physical activity. Dietary instructions and follow-up were done weekly throughout 16 weeks. Blood samples were collected to investigate serum adiponectin level and insulin resistance at the beginning and the end of the intervention. Results After 16 weeks, a significant decrease in body weight by 9.7% was associated with a significant increase in serum adiponectin from 13.3 ± 4.9 μg/ml to 18.5 ± 5.6 μg/ml. Both fasting insulin and insulin resistance had decreased significantly by 13.6% and 13.7%, respectively. Conclusion A weight reduction program depending on a reduced calorie diet for 16 weeks was associated with a significant increase in total adiponectin level and reduction in insulin resistance. An emphasis on the importance of keeping normal weight through nutritional education and the promotion of healthy diets is recommended to reduce the risk of occurrence of insulin resistance, type 2 diabetes, and cardiovascular diseases.

Does ( −)-epigallocatechin-3-gallate protect the neurotoxicity induced by bisphenol A in vivo?

“…The present study also showed that pre-treatment with EGCG 2 h before BPA resulted in a considerable reduction in body weight, which is paradoxical to the results of (Foula et al 2020), who stated that there is an inverse relationship between the serum adiponectin level and body weight. Rather than being dependent on adiponectin levels, weight reduction may be triggered by a different mechanism.…”

Effects of aerobic exercise on adiponectin levels potentially mediated by vitamin D in type 2 diabetic patients

“…This result also similar with previous study in large samples revealed lower adiponectin level in subjects with higher BMI (Nielsen et al 2020). This finding indicates that adipose tissue may exert a negative effect on adiponectin secretion as suggested in previous studies (Foula et al 2020).…”

Single Nucleotide Polymorphism in the ADIPOQ Gene Modifies Adiponectin Levels and Glycemic Control in Type Two Diabetes Mellitus Patients

“…The use of such agonists or functionally similar ligands could be tested for their efficacy in achieving glycemic control in well-designed clinical trials. Foula et al [ 47 ] described an interventional study on 95 obese or overweight premenopausal females enrolled in a controlled weight reduction program based on a balanced low-calorie diet. In their report, Foula et al [ 47 ] observed a significant decrease in the weight of females enrolled in the trial accompanied by a substantial increase in serum adiponectin.…”