Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on arterial compliance and distensibility in patients with mild-to-moderate chronic kidney disease

Veringa, Susanna J.E.; Nanayakkara, Prabath W.B.; Ittersum, Frans J. van; Vegting, I.L.; Guldener, Coen van; Smulders, Yvo M.; Wee, Piet M. ter; Stehouwer, Coen D. A.

doi:10.5414/cn107439

Cited by 9 publications

(3 citation statements)

References 42 publications

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“…Arterial stiffness decreased as a result of long-term treatment with vitamin E in combination with vitamin C, coenzyme Q10, and selenium [82]. The effect of vitamin E in combination with pravastatin and hymocysteine on arterial stiffness was studied with the aim to reduce increased aortic and carotid artery stiffness in patients with end-stage renal disease [83].…”

Section: Vitaminsmentioning

confidence: 99%

Role of Changes in State of Bound Water and Tissue Stiffness in Development of Age-Related Diseases

Kerch

2020

Polymers

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An essential effect of environmental stiffness on biological processes in cells at present is generally accepted. An increase in arterial stiffness with advanced age has been reported in many publications. The aim of the present review is to summarize current information about possible chemical reactions and physical processes that lead to tissue stiffening and result in age-related diseases in order to find methods that can prevent or retard time-dependent tissue stiffening. The analysis of published data shows that bound water acts as a plasticizer of biological tissues, a decrease in bound water content results in an increase in biological tissue stiffness, and increased tissue stiffness leads to NF-kB activation and triggered actin polymerization—NF-kB activation is associated with age-related diseases. It can be suggested that changes in bound water content through changing tissue stiffness can affect cellular processes and the development of pathologies related to aging. Both age-related diseases and COVID-19 may be associated with tight-junction disruption and increased tissue stiffness and permeability.

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Section: Vitaminsmentioning

confidence: 99%

Role of Changes in State of Bound Water and Tissue Stiffness in Development of Age-Related Diseases

Kerch

2020

Polymers

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“…In the study of Veringa et al, 93 patients with chronic kidney disease received pravastatin, vitamin E, and homocysteine lowering therapy, resulting in significant improvement of arterial compliance and distensibility, but the effect of vitamin E is not clear because it was combined with pravastatin [ 40 ].…”

Section: Vitamin Ementioning

confidence: 99%

Crosstalk between Vitamins A, B12, D, K, C, and E Status and Arterial Stiffness

2017

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Arterial stiffness is associated with cardiovascular risk, morbidity, and mortality. The present paper reviews the main vitamins related to arterial stiffness and enabling destiffening, their mechanisms of action, providing a brief description of the latest studies in the area, and their implications for primary cardiovascular prevention, clinical practice, and therapy. Despite inconsistent evidence for destiffening induced by vitamin supplementation in several randomized clinical trials, positive results were obtained in specific populations. The main mechanisms are related to antiatherogenic effects, improvement of endothelial function (vitamins A, C, D, and E) and metabolic profile (vitamins A, B12, C, D, and K), inhibition of the renin-angiotensin-aldosterone system (vitamin D), anti-inflammatory (vitamins A, D, E, and K) and antioxidant effects (vitamins A, C, and E), decrease of homocysteine level (vitamin B12), and reversing calcification of arteries (vitamin K). Vitamins A, B12, C, D, E, and K status is important in evaluating cardiovascular risk, and vitamin supplementation may be an effective, individualized, and inexpensive destiffening therapy.

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“…Vitamin E combined with Pravastatin and homocysteine-lowering therapy was evaluated against vascular stiffness progression over 18 months in patients with mild to moderate CKD. This treatment resulted in significant improvement of vascular compliance and distensibility, decrement in common carotid intima-media thickness, and increase in brachial artery flow-mediated dilatation; however, the effect of other confounding variables was unclear [ 88 , 89 ].…”

Section: Vitamin Ementioning

confidence: 99%

Naturally Occurring Compounds: New Potential Weapons against Oxidative Stress in Chronic Kidney Disease

Signorini

Granata

Lupo

et al. 2017

IJMS

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Oxidative stress is a well-described imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system of cells and tissues. The overproduction of free radicals damages all components of the cell (proteins, lipids, nucleic acids) and modifies their physiological functions. As widely described, this condition is a biochemical hallmark of chronic kidney disease (CKD) and may dramatically influence the progression of renal impairment and the onset/development of major systemic comorbidities including cardiovascular diseases. This state is exacerbated by exposure of the body to uremic toxins and dialysis, a treatment that, although necessary to ensure patients’ survival, exposes cells to non-physiological contact with extracorporeal circuits and membranes with consequent mitochondrial and anti-redox cellular system alterations. Therefore, it is undeniable that counteracting oxidative stress machinery is a major pharmacological target in medicine/nephrology. As a consequence, in recent years several new naturally occurring compounds, administered alone or integrated with classical therapies and an appropriate lifestyle, have been proposed as therapeutic tools for CKD patients. In this paper, we reviewed the recent literature regarding the “pioneering” in vivo testing of these agents and their inclusion in small clinical trials performed in patients affected by CKD.

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Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on arterial compliance and distensibility in patients with mild-to-moderate chronic kidney disease

Cited by 9 publications

References 42 publications

Role of Changes in State of Bound Water and Tissue Stiffness in Development of Age-Related Diseases

Role of Changes in State of Bound Water and Tissue Stiffness in Development of Age-Related Diseases

Crosstalk between Vitamins A, B12, D, K, C, and E Status and Arterial Stiffness

Naturally Occurring Compounds: New Potential Weapons against Oxidative Stress in Chronic Kidney Disease

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