Effect of a traditional syrup from Citrus medica L. fruit juice on migraine headache: A randomized double blind placebo controlled clinical trial

Jafarpour, Maasoumeh; Yousefi, Gholamhossein; Hamedi, Azadeh; Shariat, Abdolhamid; Salehi, Alireza; Heydari, Mojtaba

doi:10.1016/j.jep.2015.12.040

Cited by 36 publications

(17 citation statements)

References 35 publications

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“…Overall, there is significant uncertainty about the quality of studies as essential details about study designs were not reported in many publications. Many studies were also likely underpowered due to the recruitment of small sample sizes (Borhani Haghighi et al, 2010;De Weerdt et al, 1996;Delavar Kasmaei et al, 2016;Ferro et al, 2012;Grossman & Schmidramsl, 2001;Jafarpour et al, 2016;Johnson et al, 1985;Niazi et al, 2017;Oelkers-Ax et al, 2008;Palevitch et al, 1997;Parohan et al, 2019).…”

Section: Assessment Of Study Risk Of Biasmentioning

confidence: 99%

“…The efficacy of blinding also posed a potential problem in studies comprising the application of topical preparations (Borhani Haghighi et al, 2010;Niazi et al, 2017;Rafieian-Kopaei et al, 2019;Zargaran et al, 2018), and variability in treatments offered including variances in the number of tablets ingested by groups (Abdolahi et al, 2017;Parohan et al, 2019), differences in treatment administrations (i.e., syrups versus tablets) (Jafarpour et al, 2016), and variability in the intensity of the intervention offered (Ferro et al, 2012;Oelkers-Ax et al, 2008).…”

Section: Assessment Of Study Risk Of Biasmentioning

confidence: 99%

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Herbal treatments for migraine: A systematic review of randomised‐controlled studies

Lopresti

Smith

Drummond

2020

Phytotherapy Research

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Herbal treatments are often used as a treatment for migraine. Therefore, an evaluation of their safety and efficacy is important. Based on the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines, and Cochrane Collaboration's tool for assessing the risk of bias, a systematic literature review of randomised, controlled human trials assessing the effects of herbal treatments delivered as a single ingredient for the acute or prophylactic treatment of migraine were conducted. Studies were identified through electronic database searches on Medline (Pubmed), Cochrane Library, Scopus, and CINAHL. Nineteen studies were identified examining the effects on migraine of feverfew, butterbur, curcumin, menthol/peppermint oil, coriander, citron, Damask rose, chamomile, and lavender. Overall, findings on the efficacy of feverfew were mixed and there was positive, albeit limited evidence for butterbur. There were positive, preliminary findings on curcumin, citron, and coriander as a prophylactic treatment for migraine, and the use of menthol and chamomile as an acute treatment. However, the risk of bias was high for many studies. The results of this systematic review suggest that several herbal medicines, via their multifactorial physiological influences, present as potential options to enhance the treatment of migraine. However, further high‐quality research is essential to examine their efficacy and safety as a treatment for migraine.

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Section: Assessment Of Study Risk Of Biasmentioning

confidence: 99%

Section: Assessment Of Study Risk Of Biasmentioning

confidence: 99%

Herbal treatments for migraine: A systematic review of randomised‐controlled studies

Lopresti

Smith

Drummond

2020

Phytotherapy Research

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“…Headache duration was reduced when compared with placebo only (citron: mean difference 10.72, 4.83 to 16.59 v placebo: mean difference 2.70, −3.0 to 8.4 hours; P<0.0001) but not when compared with propranolol (mean difference 13.23, 5.13 to 21.31; P=0.99). 69 Omega 3 fatty acids are thought to have anti-inflammatory properties and their role in pain and headache has been investigated through supplements and dietary adjustments. An RCT in 183 patients with migraine with or without aura who were given 6 g omega 3 polyunsaturated fatty acids (OPFA) compared with placebo for four months showed no significant decrease in headache frequency from baseline (attacks per month: OPFA 2.79 (standard deviation 1.15) to 1.…”

Section: Mind-bodymentioning

confidence: 99%

Complementary and integrative medicine in the management of headache

Millstine

Chen

Bauer

2017

BMJ

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Headaches, including primary headaches such as migraine and tension-type headache, are a common clinical problem. Complementary and integrative medicine (CIM), formerly known as complementary and alternative medicine (CAM), uses evidence informed modalities to assist in the health and healing of patients. CIM commonly includes the use of nutrition, movement practices, manual therapy, traditional Chinese medicine, and mind-body strategies. This review summarizes the literature on the use of CIM for primary headache and is based on five meta-analyses, seven systematic reviews, and 34 randomized controlled trials (RCTs). The overall quality of the evidence for CIM in headache management is generally low and occasionally moderate. Available evidence suggests that traditional Chinese medicine including acupuncture, massage, yoga, biofeedback, and meditation have a positive effect on migraine and tension headaches. Spinal manipulation, chiropractic care, some supplements and botanicals, diet alteration, and hydrotherapy may also be beneficial in migraine headache. CIM has not been studied or it is not effective for cluster headache. Further research is needed to determine the most effective role for CIM in patients with headache.

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“…Sirup ini biasanya tidak langsung dikonsumsi tapi merupakan bahan baku industri minuman sari buah. Sirup buah adalah jenis yang ketiga, yaitu sirup yang cita rasanya ditentukan oleh bahan dasarnya yaitu buah segar seperti jambu, markisa, nanas, mangga dan lain-lain (Satuhu, 2004;Jafarpour et al, 2016).…”

Section: Pendahuluanunclassified

Analisis Kualitas Sirup Jeruk Baby Java Pada Stasiun Proses Dan Pendugaan Umur Simpan Skala Pilot Plant

Anggarapuri

Wijana

Pranowo

2018

JTP

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Buah jeruk merupakan salah satu buah yang berpotensi tinggi di Indonesia dengan hasil produksi menduduki peringkat ke-10 dunia. Varietas yang cukup banyak dibudidayakan yaitu jeruk manis baby java (Citrus sinensis). Jeruk diproduksi menjadi sirup dengan memperhatikan beberapa aspek, yaitu efektivitas proses terhadap penurunan kontaminasi mikroba dan masa simpan produk. Pengujian efektivitas proses dilakukan dengan mendeteksi kandungan mikroorganisme bahan setelah melewati tiap stasiun proses. Masa simpan produk diuji dengan metode Accelerated Shelf Life Time (ASLT) yang dioptimalkan dengan persamaan Arrhenius. Metode ini menggunakan faktor suhu penyimpanan sebagai penentu kecepatan reaksi kerusakan bahan. Adapun suhu penyimpanan yaitu 35 °C, 40 °C, dan 45 °C dengan parameter yang diamati yaitu total mikroba, kadar vitamin C, total padatan terlarut, dan pH. Hasil penelitian didapatkan bahwa proses produksi dapat secara signifikan menurunkan kandungan mikroba pada bahan dengan kandungan mikroba pada stasiun proses pertama dan akhir masing-masing sebesar 9.87 x 10 2 CFU/ml dan 0 CFU/ml. Pendugaan masa simpan didapatkan pH memiliki energi aktivasi (EA) terendah sebesar 467.46 dengan pendugaan apabila sirup jeruk disimpan pada suhu 7 °C dapat bertahan hingga 42 hari.

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Effect of a traditional syrup from Citrus medica L. fruit juice on migraine headache: A randomized double blind placebo controlled clinical trial

Cited by 36 publications

References 35 publications

Herbal treatments for migraine: A systematic review of randomised‐controlled studies

Herbal treatments for migraine: A systematic review of randomised‐controlled studies

Complementary and integrative medicine in the management of headache

Analisis Kualitas Sirup Jeruk Baby Java Pada Stasiun Proses Dan Pendugaan Umur Simpan Skala Pilot Plant

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