Effect of a toothpaste containing triclosan on dental plaque, gingivitis, and bleeding on probing – an investigation in periodontitis patients over 28 weeks

Abstract

The aim of this double-blind, 28-week study was to evaluate the plaque-inhibitory and antigingivitis efficacy of a fluoride toothpaste containing 0.3% triclosan and essential oil (Dental Kosmetik, Dresden, Germany) in comparison with a control toothpaste. One hundred twenty subjects previously treated for chronic periodontitis were included in the study. At baseline, 8, 18, and 28 weeks, plaque accumulation (PlI) and gingival status (GI) were assessed. Probing pocket depth (PD) and bleeding on probing (BOP) were measured at baseline and week 28 using a Florida probe. No professional hygiene was delivered during the study period. Mean plaque scores decreased between baseline and week 8 in both groups. At the end of the study, a significant increase of mean PlI compared to baseline could be observed in the test and in the control groups. Comparing the two groups, the PlI in the triclosan group was significantly lower than in the control group. Mean gingival scores decreased significantly during the first 8-week period in both groups. This reduction was followed by an increase of GI in the control, while the GI in the test group reached a significantly lower value than in controls after 28 weeks. Furthermore, at week 28, in both groups the PD were decreased as compared to the pre-study data. It is concluded that the triclosan/essential oil additive in a fluoride-containing dentifrice exhibited distinctive antigingivitis as well as plaque-inhibitory effects during a 28-week maintenance period in periodontitis patients.

Efficacy of adjunctive anti‐plaque chemical agents in managing gingivitis: a systematic review and meta‐analysis

“…Two studies included patients in supportive periodontal therapy (Bruhn et al. , Paraskevas et al. ).…”

“…When 6-month data were available, independently of the study length, 6-month data were extracted and used (n = 77). When it was not available, 7-month (n = 7) (Garcia-Godoy et al 1990, Svatun et al 1993a,b, Zimmermann et al 1993, Schaeken et al 1996, Kocher et al 2000, Bruhn et al 2002, 9month (n = 1) (Mengel et al 1996), or 12-month (n = 1) (Spets-Happonen et al 1991) data were used.…”

Assessment of the Effects of Dentifrice on Periodontal Disease Biomarkers in Gingival Crevicular Fluid

“…The active ingredient in CT, triclosan, is a proved therapeutic agent against gingivitis 20 . Most of the clinical studies with triclosan were conducted for 6 months or longer 21‐24 . However, it has been reported that triclosan's antigingivitis effect can be observed in 6 weeks 20 .…”

Use of antimicrobial agents during supportive periodontal therapy

“…However, its use may be valuable as an adjunctive therapy for patients with partial compliance to SPT appointments. Using another formulation, Bruhn et al (2002) were not able to demonstrate any advantage for triclosan regarding BOP and probing depth reduction, which are major outcome variables for SPT. At this stage, no recommendation can be concluded for use of specific toothpastes during SPT for periodontitis patients, but the development of new formulations with more SPT studies is needed.…”