Effect of a Tart Cherry Juice Supplement on Arterial Stiffness and Inflammation in Healthy Adults: A Randomised Controlled Trial

Lynn, Anthony; Mathew, Shilpa; Moore, Catherine; Russell, Jean; Robinson, Erick; Soumpasi, Vithleem; Barker, Margo E.

doi:10.1007/s11130-014-0409-x

Cited by 77 publications

(95 citation statements)

References 33 publications

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“…Lynn et al (2014) found that consumption of a tart cherry juice concentrate evoked a minor increase (p = 0.012) in plasma ferric reducing ability in a group of 25 healthy adults. However, the effect was mostly due to a decreased antioxidant status in the control group.…”

Section: In Vivo Studiesmentioning

confidence: 89%

“…This is particularly so in adipose tissue; animals prone to obesity, insulin resistance and hyperlipidemia; and older adults with compromised resistance to oxidative stress. However, the sample sizes studied are very small and the authors did not provide evidence of sufficient statistical power to detect a true difference between placebo and treatment groups [10][11][12][13][14].…”

Section: In Vivo Studiesmentioning

confidence: 97%

“…tart cherry juice from Montmorency cherries or placebo twice daily for 21 days 2014 [13] RCT parallel open-label intervention in healthy adults given 30 mL of tart cherry juice concentrate diluted to 250 mL (Cherry Active) from Montmorency cherries or control drink daily for 6 weeks…”

Section: In Vitro Studiesmentioning

confidence: 99%

“…It is possible that CVD markers examined were simply not responsive to tart cherry in normal weight, healthy adults. Finger prick capillary blood samples did not render complete data for all analyses [13].…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…The purpose of this review is to summarize and critically examine in vitro and in vivo human and animal studies (Table 1) on the efficacy of tart cherry products for pain relief in chronic diseases. Since the majority of the published human studies [10][11][12][13][14][15][16][17][18][19][20][21][22][23] are insufficiently powered, it is not possible to conduct a meta-analysis to ascertain the role of tart cherry in pain relief.…”

Section: Introductionmentioning

confidence: 99%

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Tart cherry in amelioration of pain in the elderly

Tiernan

Imrhan

Prasad

et al. 2016

NUA

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Abstract. BACKGROUND:Tart cherry, rich in bioactive polyphenols, has received attention in the past decade for reported health benefits due to its high polyphenolic content. OBJECTIVE: To determine whether there is a potential role for tart cherry or its isolated components in amelioration of pain relief in chronic diseases that may affect the elderly. METHODS:In vitro and in vivo human and animal studies that utilized tart cherry or extracts of tart cherry compounds to determine an effect on oxidative stress, inflammation, muscle damage, and pain were reviewed and summarized (Table 1). RESULTS: Tart cherry and its isolated compounds have demonstrated antioxidant and anti-inflammatory effects both in vitro and in vivo which may improve self-reported pain. In humans, these include modest improvements in gout flare incidents, and self-reported pain in fibromyalgia, osteoarthritis (OA), and conditions of induced oxidative stress and muscle damage. Beneficial biochemical changes were also reported for inflammatory and oxidative biomarkers such as serum urate, C-reactive protein (CRP), and interleukin-6 (IL-6). However, most studies reported to date have insufficient sample size, treatment duration, and statistical power to draw any firm conclusions. CONCLUSIONS: Consumption of tart cherries and their bioactive constituents may be a potential novel therapy for reducing the pain associated with chronic diseases particularly common to an aged population. Larger, more rigorous trials are needed to reach any firm conclusions.

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Section: In Vivo Studiesmentioning

confidence: 89%

Section: In Vivo Studiesmentioning

confidence: 97%

Section: In Vitro Studiesmentioning

confidence: 99%

Section: In Vivo Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Tart cherry in amelioration of pain in the elderly

Tiernan

Imrhan

Prasad

et al. 2016

NUA

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Anthocyanins in metabolic health and disease

Overall¹,

Lila²,

Komarnytsky³

2017

Nutrigenomics and Proteomics in Health and Disease

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Impact of increasing concentration of tart and sweet cherries juices concentrates on healthy mice gut microbiota

2020

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Cherries are an excellent source of dietary polyphenols and are marketed as sports and health dietary supplements. However, there are still limited direct evidence for their purported nutritional and health benefits. Gut microbiota modulation ought to be tested because most polyphenols reach the colon where they undergo microbial metabolization to bioactive and bioavailable metabolites. In the present study, varying dilutions of three concentrate cherries juices, Montmorency tart cherry juice, Balaton tart cherry juice, and sweet cherry juice, were examined to determine their potential effect on the murine gut microbiota composition. Forty-five mice were randomly assigned to three different groups. Each group received an increased concentration of its assigned juices (1/20, 1/15, 1/10, 1/7, and 1/4 [v/v]) every 5 days for 25 days. Fecal samples were collected after each concentration change for microbiota characterization by high-throughput 16S rRNA gene sequencing using Illumina Miseq. The results revealed consistent gut microbiota modulation based on concentration regardless of the juice type, but not in a true dose-dependent manner. The two median concentrations and the two highest were significantly different from each other and from the baseline and lowest concentration. Increasing cherries consumption consistently resulted in significant increase of the relative abundance of Barnesiella and Akkermansia, whereas Bacteroides abundance was negatively correlated with the concentration of the juice. Overall, we demonstrate that cherries induce a beneficial modulation of the murine gut microbiota, and that amounts of fruits consumed need to be considered to devise appropriate health and nutrition studies. K E Y W O R D S dietary supplement, gut microbiota, polyphenols, sweet cherries, tart cherries 1 INTRODUCTION Cherry fruits belong to the genus Prunus from the family Rosaceae. The most common types of cherries consumed by humans are Prunus cerasus, designated as sour or tart cherries, and Prunus avium, designated This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Effect of a Tart Cherry Juice Supplement on Arterial Stiffness and Inflammation in Healthy Adults: A Randomised Controlled Trial

Abstract: (2014). Effect of a tart cherry juice supplement on arterial stiffness and inflammation in healthy adults: a randomised controlled trial. Plant Foods for Human Nutrition, 69 (2), 122-127. Copyright and re-use policy

Cited by 77 publications

References 33 publications

Tart cherry in amelioration of pain in the elderly

Tart cherry in amelioration of pain in the elderly

Anthocyanins in metabolic health and disease

Impact of increasing concentration of tart and sweet cherries juices concentrates on healthy mice gut microbiota

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