Effect of a stearic acid-rich, structured triacylglycerol on plasma lipid concentrations

Nestel, Paul J.; Pomeroy, Sylvia; Kay, Sally; Sasahara, Takayuki; Yamashita, Takeshi

doi:10.1093/ajcn/68.6.1196

Cited by 33 publications

(18 citation statements)

References 21 publications

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“…Although animal studies (17,18) and studies in newborns (13) have shown effects of the sn-configuration of fatty acids, this effect could not be confirmed in human studies (14). Zock et al (10) concluded that a large difference in fatty acid configurations (eg, sn position) had little effect on blood lipid and lipoprotein concentrations, which is supported by others (19,20). No significant differences in the total:HDL cholesterol ratio, which is suggested to be a predictor of CVD development rather than LDL per se (21), were found after intake of the different test 2 All values are means 6 SDs.…”

Section: Discussionmentioning

confidence: 99%

Palm olein increases plasma cholesterol moderately compared with olive oil in healthy individuals

Tholstrup¹,

Hjerpsted²,

Raff³

2011

The American Journal of Clinical Nutrition

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Background: Despite the high content of palmitic acid, palm olein has been shown to have a neutral effect on plasma cholesterol concentrations when compared with olive oil, which is suggested to be attributable to palmitic acid in the sn-1 and sn-3 position. In contrast, palmitic acid is in the sn-2 position in lard. Objective: The objective was to investigate the effects of a diet rich in palm olein, fractionated palm oil, olive oil, and lard on plasma blood lipids, inflammatory markers, glucose, and insulin. Design: A controlled double-blinded, randomized 3 · 3 wk crossover dietary intervention study included 32 healthy men who daily replaced part of their habitual dietary fat intake with ;17% of energy from palm olein, olive oil, or lard, respectively. Results: Compared with intake of olive oil, palm olein and lard increased total cholesterol and LDL cholesterol (P , 0.0001). Palm olein resulted in a lower plasma triacylglycerol concentration than did olive oil (P , 0.01). No difference in effects was observed in plasma HDL-cholesterol, high-sensitivity C-reactive protein, plasminogen activator-1, insulin, and glucose concentrations. Conclusions: The current study did not support the previous finding that the effect of palm olein on total plasma cholesterol and LDL cholesterol in healthy individuals with normal plasma cholesterol concentrations is neutral compared with that of olive oil. Thus, snpositioning was not confirmed to be important with regard to the effect on plasma cholesterol. The relatively lower plasma triacylglycerol concentration after the palm olein diet than after the olive oil diet was unexpected. This trial is registered at clinicaltrials.gov as NCT00743301.

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Section: Discussionmentioning

confidence: 99%

Palm olein increases plasma cholesterol moderately compared with olive oil in healthy individuals

Tholstrup¹,

Hjerpsted²,

Raff³

2011

The American Journal of Clinical Nutrition

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“…Furthermore, studies comparing C16:0 with C18:0 demonstrated similar effects on the lipid profile. Nestel et al (1998) compared the effects on plasma lipids of a C18:0‐rich diet versus C16:0 in hypercholesterolemic subjects and demonstrated that plasma TC concentrations with the low‐fat, C18:0‐rich, and the C16:0‐rich diets were not significantly different but lower than those measured during the habitual diet period. Neither HDL‐C nor plasma TAG differed significantly among the three study diets.…”

Section: Effects Of Palm Oil and Its Fractions On Blood Lipids And LImentioning

confidence: 99%

Research advancements in palm oil nutrition

May

Nesaretnam

2014

Euro J Lipid Sci & Tech

102

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Palm oil is the major oil produced, with annual world production in excess of 50 million tonnes. About 85% of global palm oil produced is used in food applications. Over the past three decades, research on nutritional benefits of palm oil have demonstrated the nutritional adequacy of palm oil and its products, and have resulted in transitions in the understanding these attributes. Numerous studies have demonstrated that palm oil was similar to unsaturated oils with regards to effects on blood lipids. Palm oil provides a healthy alternative to trans-fatty acid containing hydrogenated fats that have been demonstrated to have serious deleterious effects on health. The similar effects of palm oil on blood lipids, comparable to other vegetable oils could very well be due to the structure of the major triglycerides in palm oil, which has an unsaturated fatty acid in the stereospecific numbers (sn)-2 position of the glycerol backbone. In addition, palm oil is well endowed with a bouquet of phytonutrients beneficial to health, such as tocotrienols, carotenoids, and phytosterols. This review will provide an overview of studies that have established palm oil as a balanced and nutritious oil.

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“…Salatrim™ had no effect on blood lipids and lipoprotein metabolism, but Caprenin™ was shown to be hypercholesterolemic in men [113,116,117]. The hypercholesterolemic effect of Caprenin™ was discussed previously.…”

Section: Introductionmentioning

confidence: 99%

Effects of stereospecific positioning of fatty acids in triacylglycerol structures in native and randomized fats: a review of their nutritional implications

2007

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Abstract

Most studies on lipid lowering diets have focused on the total content of saturated, polyunsaturated and monounsaturated fatty acids. However, the distribution of these fatty acids on the triacylglycerol (TAG) molecule and the molecular TAG species generated by this stereospecificity are characteristic for various native dietary TAGs. Fat randomization or interesterification is a process involving the positional redistribution of fatty acids, which leads to the generation of new TAG molecular species. A comparison between native and randomized TAGs is the subject of this review with regards to the role of stereospecificity of fatty acids in metabolic processing and effects on fasting lipids and postprandial lipemia. The positioning of unsaturated versus saturated fatty acids in the sn-2 position of TAGs indicate differences in early metabolic processing and postprandial clearance, which may explain modulatory effects on atherogenecity and thrombogenecity. Both human and animal studies are discussed with implications for human health.

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Effect of a stearic acid-rich, structured triacylglycerol on plasma lipid concentrations

Cited by 33 publications

References 21 publications

Palm olein increases plasma cholesterol moderately compared with olive oil in healthy individuals

Palm olein increases plasma cholesterol moderately compared with olive oil in healthy individuals

Research advancements in palm oil nutrition

Effects of stereospecific positioning of fatty acids in triacylglycerol structures in native and randomized fats: a review of their nutritional implications

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