Effect of a Single Prepubertal Injection of Testosterone Propionate on Later Reproductive Functions of the Female Golden Hamster

Alleva, Frederic R.; Alleva, John J.; Umberger, Ernest J.

doi:10.1210/endo-85-2-312

Cited by 22 publications

(12 citation statements)

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“…The effects observed after 40 days might be due to ovarian hormone secretion related to hypothalamic regulation of gonadotrophin production. Alieva et al [1969] have reported that vaginal washings present a predominance of leukocytes over cornified epithelial cells, which is in accordance with our findings of leukocytic infiltration in the epithelium of the common duct.…”

Section: Discussionsupporting

confidence: 93%

“…From the fact that steroid injections at early stages of development do not modify genital organ formation, while perinatal in jections produce striking changes in the matu ration of genital organs, one can assume that steroids interfere with the final stages of vaginal development [Alieva et at., 1969].…”

Section: Discussionmentioning

confidence: 99%

“…The vagina (from Mullerian origin) becomes nar rowed toward the sinovaginal cord an opens into the urogential sinus through a pinhole pore [Brunner andWitschi, 1946: La Velle, 1951] leaving the body with the urethra through a common opening at the base of the clitoris [Brunner andWitschi, 1946: La Velle, 1951;Alieva et at.. 1969;Jus to el al., 1974]. It offered greater than normal resistance to insertion of the dropper used in obtaining vaginal washings [Alieva et al.…”

Section: Hisanomentioning

confidence: 99%

“…Effects of prenatal and postnatal injections of testosterone propionate in hamsters have been reported in different papers by several authors [Brunner andWitschi, 1946: La Velle, 1951;Swanson, 1966;Alieva et al, 1969]. They depend on the stage of differentiation attained by the female, age and the amount of hormones injected [Brunner and Witschi, 1946].…”

Section: Introductionmentioning

confidence: 97%

“…1946 : Alieva et a!., 1969;Justo er a!., 1974], but no abnormalities were found by Swanson [1966]. External ly, experimental females exhibit a perfect male appear ance: (1) the dorsal urethra flexure becomes more pro nounced and male-like [La Velle, 1951]; (2) the clitoris is markedly enlarged because of cavernous bodies, os priapi and glans [Brunner and Witschi, 1964;La Velle, 1951], clitoris enlargement is a precocious phenomenon [Justo et at., 1974]; (3) the anophallic distance is in creased in all cases [Brunner and Witschi.…”

Section: Introductionmentioning

confidence: 99%

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Effects on hamster vaginal development of a single dose of testosterone or estradiol given neonatally

Hisano¹

1977

Cells Tissues Organs

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Postnatal injections of a single dose of testosterone propionate or estradiol benzoate to newborn female hamsters produce a precocious vaginal opening at 5 days of age. Vaginal postnatal development, histologically, has shown that in testosterone-propionate-injected animals sinusal vagina is absent. The Müllerian vagina presented a stimulated epithelium at early ages. After 40 days, the Müllerian epithelium was stratified keratinized, with zones of stratified cuboidal epithelium. In estradiol-benzoate-treated animals, the Müllerian epithelium rapidly changes to stratified keratinized epithelium (10 days), with zones of stratified cuboidal after 20 days of life. The sinusal epithelium was stratified squamous at 10 days, and after 40 days changes to stratified keratinized epithelium were seen. Probably, early changes are due to a direct effect of steroid action. Later effects are due to ovarian secretion. Histologically, no significant changes were observed in the preputial and urethral glands. The clitoris showed malformations.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%