Effect of a single preoperative dose of sublingual misoprostol on intraoperative blood loss during total abdominal hysterectomy

Biswas, Jhuma; Chaudhuri, Picklu; Mandal, Ardhendu; Bandyopadhyay, Sambhu Nath; Dasgupta, Shyamal; Pal, Anirban

doi:10.1016/j.ijgo.2013.03.025

Cited by 17 publications

(11 citation statements)

References 18 publications

(33 reference statements)

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“…Another study also supports our results by Biswas et al [14] , in which 132 patients undergoing total abdominal hysterectomy with or without bilateral salpingo-oophorectomy for symptomatic myomas were randomly allocated to receive either 400 μg of sublingual misoprostol or placebo 30 minutes before surgery. The average blood loss was significantly higher in the placebo group (435 ml) versus misoprostol group (356ml).…”

Section: Discussionsupporting

confidence: 88%

“…In the study by Kalogiannidis et al [11] , the rate of side effects was similar between groups, which agree also with the studies by Shokeir et al [13] and Biswas et al [14] .…”

Section: Discussionsupporting

confidence: 87%

“…Similarly, the study by Biswas et al [14] stated that the postoperative drop in hemoglobin was smaller in the misoprostol group (1.1g/dL) than in the placebo group (1.9 g/dL).…”

Section: Discussionmentioning

confidence: 80%

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The effect of misoprostol on intra-operative blood loss during myomectomy operation: Randomized controlled trial

Mohamed

Mansour

Shaker

2019

Evidence Based Women's Health Journal

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Introduction: Uterine myomas are most prevalent benign tumors in reproductive-aged women. Myomectomy is a surgical treatment for symptomatic uterine myomas for women who want to preserve fertility. Uncontrolled intraoperative bleeding with others life-threatening complications make the surgery risky even more than the hysterectomy and require a skilled surgeon, several methods have been developed to reduce this complications. Misoprostol PE1 analogue, which is recently used as treatment and prophylaxis of postpartum hemorrhage, may reduce intra-operative blood loss during abdominal myomectomies when bleeding constitutes a major problem. Aim of the work: Was to assess the effect part of a single dose of Misoprostol (400 microgram) given rectally one hour preoperative on the amount of blood loss during open Myomectomy. Patients and Methods: In a prospective randomized double-blind placebo-controlled trial which was conducted at Ain shams maternity Hospital in Cairo from October 2017 to May 2018, 50 women undergoing abdominal myomectomy for symptomatic uterine myomas were randomly divided into 2 groups : Group I (control group) consisted of 25 patients, each patient was given 2 tablets of placebo trans-rectally one hour preoperatively and without any intervention to reduce blood loss and Group II (study group) consisted of 25 patients, each patient was given 400 micrograms of misoprostol transrectally one hour preoperatively. The primary outcome was intraoperative blood loss. This clinical trial was registered in clinicaltrial.gov registry with number: NCT03483142. Results: Intra-operative blood loss was significantly lower in those women randomized to receive rectal misoprostol versus the placebo group (460.8-155.2 mL vs. 815.4 -187.7 mL). Misoprostol group showed lower mean blood loss (P<0.01) ; additionally, there was a highly significant statistical difference between Misoprostol group and placebo group as regards the postoperative hemoglobin, hematocrit concentration, operative time and IV fluid infusion during surgery (P<0.01) as Misoprostol group showed a higher postoperative hemoglobin and hematocrit concentration, and less operative time and infused IV fluid. There was no statistical significant difference between both groups as regards the blood transfusion. Conclusion: Preoperative single dose of rectal misoprostol (400 micrograms) is an effective simple method for reducing intra-operative bleeding, operative time, mean post-operative HB and Hct drop.

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Section: Discussionsupporting

confidence: 88%

“…In the study by Kalogiannidis et al [11] , the rate of side effects was similar between groups, which agree also with the studies by Shokeir et al [13] and Biswas et al [14] .…”

Section: Discussionsupporting

confidence: 87%

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The effect of misoprostol on intra-operative blood loss during myomectomy operation: Randomized controlled trial

Mohamed

Mansour

Shaker

2019

Evidence Based Women's Health Journal

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“…who tested the effect of using sublingual 400 μg misoprostol taken 30 min pre‐operatively in 32 women undergoing total abdominal hysterectomy (TAH) versus 32 women receiving placebo with no observed difference in intra‐operative blood loss. However, Biswas et al . showed that single dose of sublingual 400 μg misoprostol 30 min before (TAH) resulted in a significant reduction of intra‐operative blood loss.…”

Section: Discussionmentioning

confidence: 99%

Rectal misoprostol for myomectomy: A randomised placebo‐controlled study

Abdelhafeez

Elnaggar

Ali

et al. 2015

Aust NZ J Obst Gynaeco

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“…A similar conclusion was obtained by Chaiet et al (20) who tested the effect of using sublingual 400 μg misoprostol taken 30 min pre-operatively in 32 women undergoing total abdominal hysterectomy (TAH) versus 32 women receiving placebo with no observed difference in intra-operative blood loss. However, Biswas et al (21) showed that single dose of sublingual 400 μg misoprostol 30 min before (TAH) resulted in a significant reduction of intra-operative blood loss.…”

Section: Kongnyuy and Wiysongementioning

confidence: 99%

A Comparative Study Between Preoperative Use of Misoprostol and Dinoprostone for Reduction of Hemorrhage During Abdominal Myomectomy.

Naggar¹,

Sayed²,

Mohamed³

et al. 2017

IJAR

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Effect of a single preoperative dose of sublingual misoprostol on intraoperative blood loss during total abdominal hysterectomy

Abstract: The results showed that a single dose of misoprostol administered before abdominal hysterectomy resulted in a significant reduction of blood loss with minimal adverse effects. Clinical Trial Registry India (www.ctri.nic.in): CTRI/2011/091/000216.

Cited by 17 publications

References 18 publications

The effect of misoprostol on intra-operative blood loss during myomectomy operation: Randomized controlled trial

The effect of misoprostol on intra-operative blood loss during myomectomy operation: Randomized controlled trial

Rectal misoprostol for myomectomy: A randomised placebo‐controlled study

A Comparative Study Between Preoperative Use of Misoprostol and Dinoprostone for Reduction of Hemorrhage During Abdominal Myomectomy.

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