Effect of a Single Injection of Long-acting Progesterone on the First Ovulation in Early and Late Spring Transitional Mares

Staempfli, Simon A.; Clavier, Sarah; Thompson, Don; Burns, Patrick; Lyle, Sara K.; McKinnon, A. O.

doi:10.1016/j.jevs.2011.06.016

Cited by 17 publications

(12 citation statements)

References 14 publications

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“…Progesterone BioRelease ® LA was firstly used in horses, in which one dose of 1,500 mg maintained progesterone levels below 2 ng/ml (Bingle et al, ). In this work, the profile of plasma progesterone concentrations using the lower dose was similar to that previously reported in equine with a dose of 600 mg (Staempfli et al, ) and in llamas using an intravaginal progesterone‐releasing device (Chaves et al, ). These last authors observed a rapid increase in plasma progesterone concentration immediately after the insertion of the CIDR ® (Day 0), with a peak concentration on Day 1.…”

Section: Discussionsupporting

confidence: 86%

Administration of progesterone BioRelease LA inhibits follicular growth in llamas (Lama glama) regardless of follicle diameter at the start of treatment

Veiga

Trasorras

Bianchi

et al. 2018

Reprod Domestic Animals

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The aims of the study were twofold: first, the comparison of the pharmacokinetics parameters of two doses of Progesterone BioRelease LA, (BioRelease Technologies, Lexington, KY, USA) one of 300 mg and other of 150 mg and their effects on ovarian dynamics in llamas. Based on the results from the first study, the aim of the second study was to evaluate the effect of the doses of 150 mg of progesterone on follicular activity considering the stage of the largest follicle at the beginning of treatment. The results in Study 1 showed that both doses of the formulation induced plasma progesterone concentrations higher than 1 ng/ml during the first 6 days of treatment in all females, progesterone concentrations steadily decline until Day 5 following by a slowly decrease. The total amount of progesterone released during treatment was higher in Group 300 than in Group 150 (p = 0.045). Mean maximum concentrations were 14.9 ± 2.24 and 14.3 ± 2.16 ng/ml for Group A versus Group B (p = 0.58), and they were registered on Day 1.5 ± 0.22 and 1.7 ± 0.34 days, respectively (p = 0.10). None of the animals of Group A showed progesterone concentration below 1 ng/ml during all studied period. The treatment applied in Study 2 was efficient in inhibiting the ovarian follicular dynamics and to start a superestimulatory treatment. The use of progesterone Biorelease LA of 150 mg in comparison with the dose of 300 mg could be more effective in the use of synchronization protocols in llamas for AI or prior to the application of an ovarian superstimulatory treatment.

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Section: Discussionsupporting

confidence: 86%

Administration of progesterone BioRelease LA inhibits follicular growth in llamas (Lama glama) regardless of follicle diameter at the start of treatment

Veiga

Trasorras

Bianchi

et al. 2018

Reprod Domestic Animals

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“…The use of progesterone by parenteral route (Staempfli et al. ) or in microspheres (Jasko et al. ) has also been reported in the literature.…”

Section: Introductionmentioning

confidence: 98%

“…) or progesterone (Staempfli et al. ) administration, to shorten the luteal phase in cycling mares by PGF2a administration (Irvine et al. ), and to synchronize oestrus and ovulation with the use of progestagens, usually combined with ovulation inductors as HCG or deslorelin.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Different Treatments for Oestrous Induction in Seasonally Anovulatory Mares

Vizuete

Diez

Galisteo³

et al. 2012

Reprod Domestic Animals

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The aim of this study was to evaluate the effects of different treatments for induction and synchronization of oestrus and ovulation in seasonally anovulatory mares. Fifteen mares formed the control group (C), while 26 mares were randomly assigned to three treatment groups. Group T1 (n = 11) were treated with oral altrenogest (0.044 mg/kg; Regumate(®) ) during 11 days. Group T2 (n = 7) was intravaginally treated with 1.38 g of progesterone (CIDR(®) ) for 11 days. In group T3 (n = 8), mares were also treated with CIDR(®) , but only for 8 days. All mares received PGF2α 1 day after finishing the treatment. Sonographic evaluation of follicles, pre-ovulatory follicle size and ovulation time was recorded. Progesterone and leptin levels were analysed. Results show that pre-ovulatory follicles were developed after the treatment in 88.5% of mares. However, the pre-ovulatory follicle growth was dispersal, and sometimes it was detected when treatment was not finished. While in mares treated with intravaginal device, the follicle was soon detected (1.5 ± 1.2 days and 2.3 ± 2.0 days in T2 and T3 groups, respectively), in T1 group, the pre-ovulatory follicle was detected slightly later (3.9 ± 1.6 days). The interval from the end of treatment to ovulation did not show significant differences between groups (T1 = 13.1 ± 2.5 days; T2 = 11.0 ± 3.6 days; T3 = 13.8 ± 4.3 days). The pregnancy rate was 47.4%, similar to the rate observed in group C (46.7%; p > 0.05). Initial leptin concentrations were significantly higher in mares, which restart their ovarian activity after treatments, suggesting a role in the reproduction mechanisms in mares. It could be concluded that the used treatments may be effective for oestrous induction in mares during the late phase of the seasonally anovulatory period. Furthermore, they cannot synchronize oestrus, and then, it is necessary to know the reproductive status of mares when these treatments are used for oestrous synchronization.

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“…O fator mais determinante no comportamento hormonal do estro na égua parece ser a ausência de progesterona plasmática, e para tanto, esta deve estar abaixo de 1 ng/ mL (BOTELHO, 2012). Após 24 a 48 horas da ovulação, as concentrações de progesterona aumentam rapidamente para valores máximos em seis dias (6 a 10 ng/ml), permanecendo altas durante o diestro (STAEMPFLI et al, 2011), e então regridem rapidamente até atingirem os valores baixos, correspondente ao período de estro (MELO, 2012).…”

Section: Dosagem Hormonalunclassified

Monitoramento Do Ciclo Estral De Fêmeas Equinas Por Meio De Citologia Vaginal, Ultrassonografia E Dosagem Hormonal

Pimentel

Santos

Dias

et al. 2015

ArqVet

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O ciclo estral é a sincronia entre eventos comportamentais, anatômicos e endócrinos que resultam na ovulação, e pode ser dividido em fase lútea e fase folicular. A identificação das fases do ciclo estral da égua pode ser acompanhada por meio de várias biotécnicas reprodutivas como, por exemplo, citologia vaginal classificando os diversos tipos de células do epitélio vaginal, ultrassonografia para avaliação da dinâmica folicular e a dosagem hormonal no plasma sanguíneo ou das fezes do animal para caracterizar a fase do ciclo estral que o animal possivelmente se encontra. Sendo assim, o objetivo desta revisão foi discutir a fisiologia do ciclo estral de éguas, a fim de favorecer novas pesquisas relacionadas à biotécnicas reprodutivas para equinos.

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Effect of a Single Injection of Long-acting Progesterone on the First Ovulation in Early and Late Spring Transitional Mares

Cited by 17 publications

References 14 publications

Administration of progesterone BioRelease LA inhibits follicular growth in llamas (Lama glama) regardless of follicle diameter at the start of treatment

Administration of progesterone BioRelease LA inhibits follicular growth in llamas (Lama glama) regardless of follicle diameter at the start of treatment

Comparison of Different Treatments for Oestrous Induction in Seasonally Anovulatory Mares

Monitoramento Do Ciclo Estral De Fêmeas Equinas Por Meio De Citologia Vaginal, Ultrassonografia E Dosagem Hormonal

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