Effect of a single dose of phentolamine, MJ 1999 and isoproterenol on histamine-induced gastric ulcer in guinea pigs

Effects of Adrenergic Blocking Agents on Gastric Secretion and Stress-Induced Gastric Ulcer in Rats

“…As a matter of fact, yohimbine (alpha-blocker) and propranolol, MJ 1999, and alprenolol (each beta-blocker) showed significant inhibition of the ulceration with increasing doses. Djahanguiri et al (6) have reported that MJ 1999 10 mg/kg and phentolamine 2 mg/kg (i.p.) did not affect the incidence of histamine-induced ulcer in guinea pigs.…”

“…Hence, if gastric acid is a primary element in experimental ulcer, adrenergic and adrenergic blocking aegnts which have antisecretory effect should inhibit gastric ulceration. However, phentolamine, MJ 1999, and isopro terenol did not affect the incidence of histamine-induced ulcer in guinea pigs (6). More over, propranolol and phenoxybenzamine increased the incidence of ulceration in fasted rats immobilized for 8 hours (7).…”

Effects of Propranolol on Gastric Secretion in Albino Rats

“…Similar controversy exists regarding the effect of ,B-adrenoceptor antagonists on the production of experimental gastric ulcers. Rosoff & Goldman (1968), Djahanguiri, Sadeghi, Pousti, Hemmati & Firouzabadi (1968), , Kohout, Korbova & Svehlova (1970) and Pfeiffer & Sethbhakdi (1971), have reported an increase in the incidence of ulcers but Takagi, Okabe, Yano, Kawashima & Sazaki (1969), Okabe et al (1970 and Danhof & Geumei (1972), have found a significant decrease in the incidence of gastric ulcerations. It was, therefore, thought worthwhile to study the dose-response relationship of the effects of propranolol on both gastric secretion and gastric ulcer production in albino rats.…”

Effect of Atropine, Phentolamine and MJ 1999 on Promethazine-induced Gastric Ulcer in Guinea-pigs

“…It has been demonstrated that the occurrence of histamine-in duced gastric ulcers in the guinea-pigs is not influenced by alpha or beta blocking agents of the sympathetic nervous system [2],…”