2022
DOI: 10.1101/2022.02.22.22271335
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Effect of a single dose of 8 mg moxidectin or 150 µg/kg ivermectin on O. volvulus skin microfilariae in a randomized trial: Differences between areas in the Democratic Republic of the Congo, Liberia and Ghana and impact of intensity of infection

Abstract: Background Community-directed treatment with 150 μg/kg ivermectin (CDTI), the current control strategy, is insufficient for eliminating Onchocerca volvulus transmission across sub-Saharan Africa. Our study in CDTI-naïve areas in Nord Kivu and Ituri (Democratic Republic of the Congo (DRC), Lofa County (Liberia) and Nkwanta district (Ghana) showed that a single 8 mg moxidectin dose reduced skin microfilariae density (microfilariae/mg skin, SmfD) better and for longer than a single 150μg/kg ivermectin dose. M… Show more

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