Effect of a single course of isotretinoin therapy on bone mineral density in adolescent patients with severe, recalcitrant, nodular acne

DiGiovanna, John J.; Langman, Craig B.; Tschen, Eduardo; Jones, Terry M.; Menter, Alan; Lowe, Nicholas J.; Eichenfield, Lawrence F.; Hebert, Adelaide A.; Pariser, David M.; Savin, Ronald P.; Smith, Stacy; Jarratt, Michael; Rodríguez, David Avelar; Chalker, Dan K.; Kempers, Steven; Ling, Mark; Rafal, Elyse S.; Sullivan, Sabra; Kang, Sewon; Shah, Leena; Wu, Emily S.; Newhouse, Julie; Pak, Jonathan; Eberhardt, Douglas; Bryce, Graeme F.; McLane, John A.; Ondovik, Michael S.; Chin, Catherine M.; Khoo, Ko Chin; Rich, Phoebe

doi:10.1016/j.jaad.2004.04.032

Cited by 47 publications

(35 citation statements)

References 32 publications

(32 reference statements)

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“…The largest previously published multicenter study tested the effect of isotretinoin on pediatric spine BMD (g/cm 2 ) using a Lunar DXA in 217 subjects and demonstrated a statistically significant, mean positive effect on the spine after 16-20 weeks of treatment (+1.4 %) [11]. Similar results have been found in other studies of pediatric subjects [2,7,8].…”

Section: Discussionsupporting

confidence: 76%

“…At least two single-center studies have described bone lucency, or osteopenia, in subjects treated with isotretinoin [5,6]. Multiple studies with similar average treatment doses to those reported in this study have not demonstrated a decrease in the lumbar spine and hip BMD using dual X-ray absorptiometry (DXA) in pediatric or adult subjects [7][8][9][10][11]. A single-center study in [17][18][19][20][21][22][23][24][25] year-old men identified no significant difference in the spine or femoral neck BMD; however, a decrease in Ward's triangle BMD was described [2].…”

Section: Introductionmentioning

confidence: 59%

See 1 more Smart Citation

A double-blind, randomized, Phase III, multicenter study in 358 pediatric subjects receiving isotretinoin therapy demonstrates no effect on pediatric bone mineral density

Hoover

Miller²,

Galante

et al. 2015

Osteoporos Int

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 59%

A double-blind, randomized, Phase III, multicenter study in 358 pediatric subjects receiving isotretinoin therapy demonstrates no effect on pediatric bone mineral density

Hoover

Miller²,

Galante

et al. 2015

Osteoporos Int

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“…There is little scientific support for osteoporosis associated with isotretinoin, nor is there support for reduced gains in bone mass in adolescents on isotretinoin. [57][58][59] To date, however, the largest study on bone mass and isotretinoin has been of approximately 200 patients, and this sample size may not be large enough to detect a small change in bone mass.…”

Section: Bone and Musclementioning

confidence: 99%

Preventing and Managing the Side Effects of Isotretinoin

Brelsford¹,

Beute²

2008

Seminars in Cutaneous Medicine and Surgery

123

111

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“…While long term retinoid therapy has been shown to be associated with osteoporosis in some older studies (10, 11) more recent investigations have denied any association (12). Short term acitretin has not been shown to result in decrease in bone density (13). Isotretinoin was shown to have no effect on bone density in a recent double-blind randomized study which followed 358 teenagers for 5.5 months (14).…”

Section: Concomitant Extraspinal Hyperostosis and Osteoporosis In A Pmentioning

confidence: 99%

Concomitant extraspinal hyperostosis and osteoporosis in a patient with congenital ichthyosis

Torkamani

Phal

Savarirayan

et al. 2016

ccmbm

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SummaryIchthyosiform dermatosis is a term referred to a group of disorders that have as their basis a disorder of keratinization (1). These conditions which are present at birth result in a generalized dry, scaly skin without any inflammation. There are several types of ichthyosis based on their clinical presentation and mode of inheritance. The most common types are: ichthyosis vulgaris, X-linked recessive ichthyosis, epidermolytic hyperkeratosis (bullous), lamellar ichthyosis and non-bullous ichthyosiform erythroderma. Lamellar ichthyosis, which is inherited in an autosomal recessive pattern, shows genetic heterogeneity with the most severe type being due to mutations in the transglutaminase-1 gene. This condition presents with skin changes at birth and cases are referred to as collodion babies. Initially, the stratum corneum is smooth and appears as though it is covered with cellophane. This layer is discarded a few days after birth, leaving a generalized inflamed and scaly appearance. The skin is tight at this stage and may cause ectropion, and difficulties in feeding and temperature regulation. Lamellar ichthyosis is characterized by plate-like scales that last for life and can significantly impact the patient's quality of life (2). We report here a case of multiple extraspinal hyperostoses concomitant with marked osteoporosis and vitamin D deficiency in a patient taking acitretin for 20 years due to severe congenital lamellar ichthyosis.

show abstract

Effect of a single course of isotretinoin therapy on bone mineral density in adolescent patients with severe, recalcitrant, nodular acne

Cited by 47 publications

References 32 publications

A double-blind, randomized, Phase III, multicenter study in 358 pediatric subjects receiving isotretinoin therapy demonstrates no effect on pediatric bone mineral density

A double-blind, randomized, Phase III, multicenter study in 358 pediatric subjects receiving isotretinoin therapy demonstrates no effect on pediatric bone mineral density

Preventing and Managing the Side Effects of Isotretinoin

Concomitant extraspinal hyperostosis and osteoporosis in a patient with congenital ichthyosis

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