Effect of a Second Injection of Botulinum Toxin on Lower Facial Contouring, as Evaluated Using 3-Dimensional Laser Scanning

Lee, Hong Hee; Kim, Seong Taek; Lee, Kee Joon; Baik, Hyoung Seon

doi:10.1097/dss.0000000000000291

Cited by 20 publications

(13 citation statements)

References 12 publications

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“…This means that additional injection of BoNT-A is required to sustain its effect in the lower facial contour. In the present study, we found that repeated injections of BoNT-A induced a greater reduction of masseter muscle thickness and cross-sectional area than did a single injection, as reported by Lee et al18 This indicates that repeated injections of BoNT-A were more effective in improving masseteric hypertrophy, and suggests that repeated injections might induce more bony changes.…”

Section: Discussionsupporting

confidence: 89%

Repeated injections of botulinum toxin into the masseter muscle induce bony changes in human adults: A longitudinal study

et al. 2017

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ObjectiveTo evaluate soft- and hard-tissue changes in the mandibular angle area after the administration of botulinum toxin type A (BoNT-A) injection to patients with masseteric hypertrophy by using three-dimensional cone-beam computed tomography (3D-CBCT).MethodsTwenty volunteers were randomly divided into two groups of 10 patients. Patients in group I received a single BoNT-A injection in both masseter muscles, while those in group II received two BoNT-A injections in each masseter muscle, with the second injection being administered 4 months after the first one. In both groups, 3D-CBCT was performed before the first injection and 6 months after the first injection.ResultsMasseter muscle thicknesses and cross-sectional areas were significantly reduced in both groups, but the reductions were significantly more substantial in group II than in group I. The intergonial width of the mandibular angle area did not change significantly in either group. However, the bone volume of the mandibular gonial angle area was more significantly reduced in group II than in group I.ConclusionsThe repeated administration of BoNT-A injections may induce bone volume changes in the mandibular angle area.

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Section: Discussionsupporting

confidence: 89%

Repeated injections of botulinum toxin into the masseter muscle induce bony changes in human adults: A longitudinal study

et al. 2017

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“…75,76 The same is also true on an inter-patient basis. In a comparison of onset and duration of effect in the glabellar region with ABO, ONA, and INCO, Rappl et al noted that subjects with the longest duration of response had mild wrinkles at baseline and very thin corrugator muscles.…”

Section: The Influence Of Muscle Mass On Abo Efficacymentioning

confidence: 65%

Key Parameters for the Use of AbobotulinumtoxinA in Aesthetics: Onset and Duration

Nestor

Ablon

Pickett

2017

Aesthetic Surgery Journal

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Time to onset of response and duration of response are key measures of botulinum toxin efficacy that have a considerable influence on patient satisfaction with aesthetic treatment. However, there is no overall accepted definition of efficacy for aesthetic uses of botulinumtoxinA (BoNT-A). Mechanical methods of assessment do not lend themselves to clinical practice and clinicians rely instead on assessment scales such as the Frontalis Activity Measurement Standard, Frontalis Rating Scale, Wrinkle Severity Scale, and Subject Global Assessment Scale, but not all of these have been fully validated. Onset of activity is typically seen within 5 days of injection, but has also been recorded within 12 hours with abobotulinumtoxinA. Duration of effect is more variable, and is influenced by parameters such as muscle mass (including the effects of age and sex) and type of product used. Even when larger muscles are treated with higher doses of BoNT-A, the duration of effect is still shorter than that for smaller muscles. Muscle injection technique, including dilution of the toxin, the volume of solution injected, and the positioning of the injections, can also have an important influence on onset and duration of activity. Comparison of the efficacy of different forms of BoNT-A must be made with the full understanding that the dosing units are not equivalent. Range of equivalence studies for abobotulinumtoxinA (Azzalure; Ipsen Limited, Slough UK/Galderma, Lausanne CH/Dysport, Ipsen Biopharm Limited, Wrexham UK/Galderma LP, Fort Worth, TX) and onabotulinumtoxinA (Botox; Allergan, Parsippany, NJ) have been conducted, and results indicate that the number of units of abobotulinumtoxinA needs to be approximately twice as high as that of onabotulinumtoxinA to achieve the same effect. An appreciation of the potential influence of all of the parameters that influence onset and duration of activity of BoNT-A, along with a thorough understanding of the anatomy of the face and potency of doses, are essential to tailoring treatment to individual patient needs and expectations.

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“…Perhaps owing to the low incidence rate, reports on the complications of toxin injections for masseter hypertrophy remain rare or even unobserved in certain studies despite the treatment's popularity. 1,[15][16][17][18][19][20][21][22][23][24][25][26][27] Current literature does not offer comprehensive reviews of the time, prognosis, or recovery process of related complications, and the Cochrane review in 2009 and 2013 reported an insufficient amount of high level evidence to accurately assess the efficacy and safety of toxin injections for masseter hypertrophy. 28,29 A previous report by the authors in 2018 outlined masseter toxin injection complication rates from 2036 treatments, 30 though it was limited in scope to a single clinic.…”

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confidence: 99%

Literature review of the adverse events associated with botulinum toxin injection for the masseter muscle hypertrophy

Yeh¹,

Peng²,

Peng³

2018

J of Cosmetic Dermatology

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Botulinum toxin masseter injections are commonly performed procedures with good results and safety profiles. The majority of complications appeared within 2-4 weeks of injection and disappeared within 12 weeks. Despite the temporary nature of these complications, they often decrease patient satisfaction and confidence, so physicians should familiarize themselves with the regional anatomy and injection safety zones.

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Effect of a Second Injection of Botulinum Toxin on Lower Facial Contouring, as Evaluated Using 3-Dimensional Laser Scanning

Abstract: The administration of a second BoNT-A injection is effective for better aesthetic results for the lower facial contour.

Cited by 20 publications

References 12 publications

Repeated injections of botulinum toxin into the masseter muscle induce bony changes in human adults: A longitudinal study

Repeated injections of botulinum toxin into the masseter muscle induce bony changes in human adults: A longitudinal study

Key Parameters for the Use of AbobotulinumtoxinA in Aesthetics: Onset and Duration

Literature review of the adverse events associated with botulinum toxin injection for the masseter muscle hypertrophy

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