Effect of a purine derivative containing selenium to improve memory decline and anxiety through modulation of the cholinergic system and Na+/K+-ATPase in an Alzheimer’s disease model

Pinz, Mikaela P.; Vogt, Ane G.; Rodrigues, Karline da Costa; Reis, Angélica S.; Duarte, Luis Fernando B.; Fronza, Mariana G.; Domingues, William Borges; Blodorn, Eduardo; Alves, Diego; Campos, Vinícius Farias; Savegnago, Lucielli; Wilhelm, Ethel A.; Luchese, Cristiane

doi:10.1007/s11011-021-00703-w

Cited by 18 publications

(13 citation statements)

References 71 publications

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“…(a) studies of selenium, selenoproteins and selenium-containing compounds in relation to anxiety in animal models (n = 16) [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57] (b) observational studies measuring dietary selenium intake, levels of serum selenium or other selenium-related biomarkers in patients with either anxiety disorders or symptoms of anxiety (n = 7) [58][59][60][61][62][63][64] (c) clinical trials of selenium or selenium-containing supplements in the prevention or management of anxiety and related disorders (n = 7), including two studies of selenium and five studies of selenium as one of the components of a nutritional supplement. [65][66][67][68][69][70][71] Due to the heterogeneity in patient populations, study objectives and outcome measures in the clinical trials, a formal meta-analysis was not undertaken for these studies.…”

Section: Methodsmentioning

confidence: 99%

“…Sixteen of the papers included in this review belonged to this category [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57]. Methodological details and results for each of these studies are summarized in Table 1.…”

Section: Selenium Selenoproteins and Selenium-containing Compounds In...mentioning

confidence: 99%

“…Methodological details and results for each of these studies are summarized in Table 1. Fourteen studies examined the effects of selenium or selenium compounds on animal models of anxiety [43][44][45][46][47][48][49][50][51][52][53][54][55][56]. Of these studies, the majority (n = 10) used organic seleniumcontaining compounds as interventions, while two used elemental selenium and two used sodium selenite.…”

Section: Selenium Selenoproteins and Selenium-containing Compounds In...mentioning

confidence: 99%

“…Various procedures were used for the induction of anxiety in experimental animals. In seven studies, anxiety was induced by the administration of a drug or toxin: these included lipopolysaccharide (LPS) (n = 2), streptozotocin (n = 2), corticosterone, kainate and arsenic (n = 1 each) [45,48,50,51,[54][55][56]. In two studies, anxiety was induced by subjecting animals to acute restraint [49,53].…”

Section: Selenium Selenoproteins and Selenium-containing Compounds In...mentioning

confidence: 99%

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Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research

Rajkumar¹

2022

Preprint

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Anxiety disorders are among the most common mental disorders worldwide, and often respond incompletely to existing treatments. Selenium, a micronutrient that is a component of several biologically active selenoproteins, is also involved in several aspects of brain functioning, and may exert antidepressant and anxiolytic effects through multiple pathways. The current paper is a scoping review of translational, observational and interventional evidence on the potential role of selenium and its compounds in the management of anxiety and related disorders. Evidence from animal models suggests that this approach may be promising. Though evidence from observational studies in humans is inconsistent and affected by several confounding factors, the available evidence from randomized controlled trials suggests that selenium supplementation may be beneficial in the management of certain anxiety-related conditions, such as anxiety in medically ill patients, prevention of anxiety following exposure to traumatic stress, and obsessive-compulsive disorder. This paper provides a critical evaluation of the existing evidence base, including unanswered questions that could serve as the focus of further research, and outlines the potential benefits and risks associated with the use of selenium in anxiety disorders.

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Section: Methodsmentioning

confidence: 99%

Section: Selenium Selenoproteins and Selenium-containing Compounds In...mentioning

confidence: 99%

Section: Selenium Selenoproteins and Selenium-containing Compounds In...mentioning

confidence: 99%

Section: Selenium Selenoproteins and Selenium-containing Compounds In...mentioning

confidence: 99%

See 2 more Smart Citations

Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research

Rajkumar¹

2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Sixteen of the papers included in this review belonged to this category [43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58]. Methodological details and results for each of these studies are summarized in Table 1.…”

Section: Selenium Selenoproteins and Selenium-containing Compounds In...mentioning

confidence: 99%

Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research

Rajkumar

2022

Future Pharmacology

View full text Add to dashboard Cite

Anxiety disorders are among the most common mental disorders worldwide and often respond incompletely to existing treatments. Selenium, a micronutrient that is a component of several biologically active selenoproteins, is also involved in several aspects of brain functioning and may exert antidepressant and anxiolytic effects through multiple pathways. The current paper is a scoping review of translational, observational, and interventional evidence on the potential role of selenium and its compounds in the management of anxiety and related disorders. Evidence from animal models suggests that this approach may be promising. Though evidence from observational studies in humans is inconsistent and affected by several confounding factors, the available evidence from randomized controlled trials suggests that selenium supplementation may be beneficial in the management of certain anxiety-related conditions, such as anxiety in medically ill patients, prevention of anxiety following exposure to traumatic stress, and obsessive-compulsive disorder. This paper provides a critical evaluation of the existing evidence base, including unanswered questions that could serve as the focus of further research, and outlines the potential benefits and risks associated with the use of selenium in anxiety disorders.

show abstract

Neuro-amelioration of Ficus lyrata (fiddle-leaf fig) extract conjugated with selenium nanoparticles against aluminium toxicity in rat brain: relevance to neurotransmitters, oxidative, inflammatory, and apoptotic events

Elganzoury

Abdelfattah

Habotta

et al. 2023

Environ Sci Pollut Res

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Effect of a purine derivative containing selenium to improve memory decline and anxiety through modulation of the cholinergic system and Na+/K+-ATPase in an Alzheimer’s disease model

Cited by 18 publications

References 71 publications

Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research

Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research

Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research

Neuro-amelioration of Ficus lyrata (fiddle-leaf fig) extract conjugated with selenium nanoparticles against aluminium toxicity in rat brain: relevance to neurotransmitters, oxidative, inflammatory, and apoptotic events

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