Effect of a protein meal in stomach and jejunum on gastric secretory response to pentagastrin in cats

Abstract

A humoral gastrin potentiating mechanism was previously demonstrated in the upper intestine of cats. The present study was carried out on 10 cats with a gastric fistula (GF) and a Heidenhain pouch (HP). In five of the cats the duodenum and proximal jejunum were excluded as a Roux-en-Y loop, and the other cats were provided with an isolated jejunal Thirty-Vella loop. In the Roux-en-Y loop cats, a protein-rich oral meal augmented the maximal HP acid response to pentagastrin but not the pepsin response. Protein-rich food in the Thirty-Vella loop did not stimulate acid secretion, nor did it augment the maximal GF or HP acid response to pentagastrin. Previous and present results suggest that an unknown humoral gastrin-potentiating mechanism is activated by a protein-rich meal in the stomach and the duodenum but not in the jejunum. The mechanism potentiates pentagastrin-induced acid, but not pepsin, secretion.

Antrum participates in the postprandial augmentation of the acid response to exogenous gastrin in conscious cats

“…Similar results have been reported after antrectomy in dogs (Keuppens et al 1976) and peptic ulcer patients (Saik et al 1977). In cats, meat in the duodenum did not alter serum gastrin concentration (Fernstrom et al 1984), and the gastrin response to oral feeding was not changed by exclusion of the proximal small intestine (Fernstrom et al 1982). The present finding that antrectomy and exclusion abolished the postprandial gastrin response therefore suggests that the response is of antral origin.…”

“…A protein-rich meal potentiated the maximal HP acid response to pentagastrin in cats with the duodenum excluded (Fernstrom & E m i s 1985). These findings (Fernstrom et al 1984, Fernstrom & E m i s 1985) indicated a postprandial humoral gastrin-potentiating mechanism in cats, localized to the stomach and duodenum, but not to the jejunum. T h a t the mechanism is situated in both Correspondence: Sverre Emis, M.D., Department of Surgery, Karolinska Hospital, Box 60500, S-104 01 Stockholm, Sweden.…”

“…the maximal acid response to pentagastrin in gastric fistula and Heidenhain pouch (HP) cats (Fernstrom et al 1984), but food in the jejunum did not (Fernstrom & E m i s 1985). A protein-rich meal potentiated the maximal HP acid response to pentagastrin in cats with the duodenum excluded (Fernstrom & E m i s 1985).…”

“…T h e effect of feeding on the maximal acid response to pentagastrin was studied in HP cats with antrectomy and duodenal exclusion. T h e exclusion was performed to avoid interference with the potentiating mechanism in the duodenum (Fernstrom et al 1984). T h e same experiments were performed on a control group of HP cats 265 with normal gastro-intestinal continuity, in which the pepsin responses were also determined.…”

Gastric Acid Response to Pentagastrin and Gastrin-Releasing Peptide in Conscious Cats

“…In previous studies on cats, protein-rich food in the duodenum potentiated the maxi mal acid response to pentagastrin both in the GF and HP [19] and food in the stomach enhanced the response in the HP [20]. The mechanism for the enhancement is un known, but GRP is an unlikely mediator, since it did not alter the HP response to pen tagastrin in the present study.…”