1999
DOI: 10.2527/1999.7792523x
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Effect of a prolonged low-dose lipopolysaccharide infusion on feed intake and metabolism in heifers.

Abstract: Prolonged infusions of bacterial lipopolysaccharides (LPS) are known to model gram-negative bacterial infections, but the basic mechanisms of the LPS effects on feed intake and metabolism and their potential interdependence are largely unknown. The aim of the present study was to distinguish and to better characterize the feeding suppressive and metabolic effects of LPS. Six heifers were infused intravenously for 100 min with either 1) LPS (2 microg/kg BW) with free access to feed, 2) saline with free access t… Show more

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Cited by 116 publications
(140 citation statements)
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“…The previous studies showed that cytokines secreted by immune cells can activate the hypothalamic-pituitary-adrenal axis (HPA) after dairy cows were subjected to LPS injection (Steiger et al, 1999;Waldron et al, 2003). The results from Karrow et al (2010) also showed that sheep injected with interleukine-6 stimulated cortisol and corticotrophin hormone secretion into the peripheral circulating system, indicating a cross-talk of immune system and the HPA axis.…”
Section: Introductionmentioning
confidence: 77%
“…The previous studies showed that cytokines secreted by immune cells can activate the hypothalamic-pituitary-adrenal axis (HPA) after dairy cows were subjected to LPS injection (Steiger et al, 1999;Waldron et al, 2003). The results from Karrow et al (2010) also showed that sheep injected with interleukine-6 stimulated cortisol and corticotrophin hormone secretion into the peripheral circulating system, indicating a cross-talk of immune system and the HPA axis.…”
Section: Introductionmentioning
confidence: 77%
“…As whole-body insulin resistance was not induced by the LPS infusion, our data showed the liver as a first target of LPS-induced insulin resistance. The role of LPS as a regulator of energy metabolism has been proposed previously (32,33). In most of the studies that described the anorectic and metabolic effects of LPS, endotoxemia was very elevated or given as single shot and witnessed a state of acute phase infection.…”
Section: Discussionmentioning
confidence: 99%
“…Experiments with intravenously administered bacteria (Ruot et al, 2000;Papet et al, 2002), lipopolysaccharide, LPS, (Steiger et al, 1999), and local (nasal or oral) bacterial (Wannemacher et al, 1971;Powanda et al, 1972;Wannemacher et al, 1974), or, bacterial antigen challenges (Klasing et al, 1987;Arnold et al, 1989) have shown reductions in growth that were not accounted for by reduced VFI. Challenges with LPS, while not a 'true' bacterial challenge, stimulate a similar kind of response, but of smaller and shorter magnitude, to that of bacterial challenges.…”
Section: The Characteristics Of Reductions In Growth During Pathogen mentioning
confidence: 99%