Effect of a Probiotic Preparation on Ventilator‐Associated Pneumonia in Critically Ill Patients Admitted to the Intensive Care Unit: A Prospective Double‐Blind Randomized Controlled Trial

Mahmoodpoor, Ata; Hamishehkar, Hadi; Asghari, Roghaieh; Abri, Ramin; Shadvar, Kamran; Sanaie, Sarvin

doi:10.1002/ncp.10191

Cited by 75 publications

(98 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…So, we considered one of the main secondary objectives to estimate the required sample size. Mahmoodpoor and co-workers (35) reported the ICU stay in the two study groups as 18.6±8 and 11.6±6.3 days. Considering alfa error as 0.05 and a power of 80%, the required sample size with a 10% dropout was 20 patients in each group.…”

Section: Sample Size and Randomizationmentioning

confidence: 91%

Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies

Seifi

Safarian

Nematy

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Among critically ill patients, regardless of the heterogeneity of disease state, an extreme and persistent dysbiosis occurs. Dysbiosis in critically ill patients may make them prone to hospital-acquired infections, sepsis, multi-organ failure (MOF), energy homeostasis disturbance, muscle wasting, and cachexia. Modulation of gut microbiota through synbiotics can be considered as a potential treatment for muscle wasting and macronutrients homeostasis disturbances. Methods: This is a prospective, single center, double-blind; a parallel randomized controlled trial that aimed to evaluate the effects of synbiotic supplementation on energy and macronutrient ‎homeostasis and muscle wasting in critical care patients.‎ A total of 40 hemodynamically- stable adult critically ill patients who receive enteral nutrition via nasogasteric tube (NGT) in the 24-48h after admission will be included in this study. Eligible patients will be randomly assigned to receive Lactocare (ZistTakhmir) capsules 500 mg every 12h or a placebo capsule which contains only the sterile maize starch and is similar to synbiotic capsules for 14 days. The synbiotic and placebo capsules will be given through nasogastric tube, separately from gavage, after feeding. Discussion: Gut microbiota modulation through synbiotics is proposed to improve clinical prognosis and reduce infectious complications, ventilator dependency and ICU stay by improving energy and macronutrient homeostasis and reducing muscle protein catabolism.

show abstract

Section: Sample Size and Randomizationmentioning

confidence: 91%

Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies

Seifi

Safarian

Nematy

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…So, we considered one of the main secondary objectives to estimate the required sample size. Mahmoodpoor and co-workers [35] reported the ICU stay in two study groups as 18.6 ± 8 and 11.6 ± 6.3 days. Considering alpha error of 0.05 and power of 80%, the required sample size allowing for 10% dropout is 20 patients in each group.…”

Section: Sample Size and Randomizationmentioning

confidence: 93%

Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies

Seifi

Safarian

Nematy

et al. 2020

Trials

View full text Add to dashboard Cite

Background: An extreme and persistent dysbiosis occurs among critically ill patients, regardless of the heterogeneity of disease. Dysbiosis in critically ill patients may make them prone to hospital-acquired infections, sepsis, multi-organ failure (MOF), energy homeostasis disturbance, muscle wasting, and cachexia. Modulation of gut microbiota through synbiotics can be considered as a potential treatment for muscle wasting and macronutrient homeostasis disturbances.Methods: This is a prospective, single-center, double-blind, parallel randomized controlled trial with the aim to evaluate the effects of synbiotic supplementation on energy and macronutrient homeostasis and muscle wasting in critically ill patients. A total of 40 hemodynamically stable, adult, critically ill patients who receive enteral nutrition via a nasogasteric tube (NGT) in the 24-48 h after admission to critical care will be included in this study. Eligible patients will be randomly assigned to receive Lactocare (ZistTakhmir) capsules 500 mg every 12 h or a placebo capsule, which contains only the sterile maize starch and is similar to synbiotic capsules for 14 days. The synbiotic and placebo capsules will be given through the nasogastric tube, separately from gavage, after feeding. Discussion: Gut microbiota modulation through synbiotics is proposed to improve clinical prognosis and reduce infectious complications, ventilator dependency, and length of ICU stay by improving energy and macronutrient homeostasis and reducing muscle protein catabolism.

show abstract

“…Clinical evidence demonstrates that certain probiotic strains support the prevention of viral infections of the respiratory tract [ 109 , 113 , 115 , 116 ], as is the case of COVID-19. Particularly, studies show that patients on mechanical ventilation who were administered probiotics had significantly less ventilator-associated pneumonia [ 117 , 118 ]. Additionally, probiotic strains have been shown to modify the balance between proinflammatory and immunoregulatory cytokines [ 116 ], which allows viral clearance, while minimizing immune response-mediated lung damage.…”

Section: Therapeutic Opportunities For Covid-19 With Impact On Thementioning

confidence: 99%

Gut Microbiota Dysbiosis–Immune Hyperresponse–Inflammation Triad in Coronavirus Disease 2019 (COVID-19): Impact of Pharmacological and Nutraceutical Approaches

2020

View full text Add to dashboard Cite

Coronavirus Disease 2019 (COVID-19) is a pandemic infection caused by a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients present a complex clinical picture that, in severe cases, evolves to respiratory, hepatic, gastrointestinal, and neurological complications, and eventually death. The underlying pathophysiological mechanisms are complex and multifactorial and have been summarized as a hyperresponse of the immune system that originates an inflammatory/cytokine storm. In elderly patients, particularly in those with pre-existing cardiovascular, metabolic, renal, and pulmonary disorders, the disease is particularly severe, causing prolonged hospitalization at intensive care units (ICU) and an increased mortality rate. Curiously, the same populations have been described as more prone to a gut microbiota (GM) dysbiosis profile. Intestinal microflora plays a major role in many metabolic and immune functions of the host, including to educate and strengthen the immune system to fight infections, namely of viral origin. Notably, recent studies suggest the existence of GM dysbiosis in COVID-19 patients. This review article highlights the interplay between the triad GM dysbiosis–immune hyperresponse–inflammation in the individual resilience/fragility to SARS-CoV-2 infection and presents the putative impact of pharmacological and nutraceutical approaches on the triumvirate, with focus on GM.

show abstract

Effect of a Probiotic Preparation on Ventilator‐Associated Pneumonia in Critically Ill Patients Admitted to the Intensive Care Unit: A Prospective Double‐Blind Randomized Controlled Trial

Cited by 75 publications

References 38 publications

Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies

Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies

Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies

Gut Microbiota Dysbiosis–Immune Hyperresponse–Inflammation Triad in Coronavirus Disease 2019 (COVID-19): Impact of Pharmacological and Nutraceutical Approaches

Contact Info

Product

Resources

About