Effect of a plant-based bioequivalent inorganic nitrate (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.svg"><mml:mrow><mml:msubsup><mml:mtext>NO</mml:mtext><mml:mn>3</mml:mn><mml:mo>−</mml:mo></mml:msubsup></mml:mrow></mml:math>) complex with vitamins, antioxidants and phytophenol rich food extracts in hypertensive individuals - A randomized, double-blind, placebo-controlled study

Cherukuri, Lavanya; Birudaraju, Divya; Kinninger, April; Chaganti, Bhanu T.; Shekar, Chandana; Hamal, Sajad; Shaikh, Kashif; Flores, Ferdinand; Roy, Sion K.; Sotka, William; Green, Shawn J.; Budoff, Matthew J.

doi:10.1016/j.clnesp.2020.08.007

Cited by 8 publications

(3 citation statements)

References 49 publications

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“…3 ) [76], and a reduction of the hepatic glucose production as due to the hormonal regulation [77]. Additionally, a better blood lipid profile increases the lipoproteins lipase activity as ApoB in muscle capillaries and, subsequently, promotes a concomitant oxidation of free fatty acids (FFA) in trained muscle cells, by diminishing the ectopic lipid deposition and lipotoxicity [78].…”

Section: Discussionmentioning

confidence: 99%

Structural Equation Modelling for Predicting the Relative Contribution of Each Component in the Metabolic Syndrome Status Change

Teixeira

Bragada

et al. 2022

IJERPH

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Understanding the factor weighting in the development of metabolic syndrome (MetS) may help to predict the progression for cardiovascular and metabolic diseases. Thus, the aim of this study was to develop a confirmatory model to describe and explain the direct and indirect effect of each component in MetS status change. A total of 3581 individuals diagnosed with MetS, aged 18–102 years, were selected between January 2019 and December 2020 from a community-representative sample of Portuguese adults in a north-eastern Portuguese region to test the model’s goodness of fit. A structural equation modelling (SEM) approach and a two-way ANOVA (age × body composition) were performed to compare the relative contribution of each MetS component using joint interim statement (JIS). Waist circumference (β = 0.189–0.373, p < 0.001), fasting glucose (β = 0.168–0.199, p < 0.001) and systolic blood pressure (β = 0.140–0.162, p < 0.001) had the highest direct effect on the change in MetS status in the overall population and concerning both sexes. Moreover, diastolic blood pressure (DBP), triglycerides (TG) and high-density lipoprotein cholesterol (HDL-c) had a low or non-significant effect. Additionally, an indirect effect was reported for age and body composition involving the change in MetS status. The findings may suggest that other components with higher specificity and sensitivity should be considered to empirically validate the harmonised definition of MetS. Current research provides the first multivariate model for predicting the relative contribution of each component in the MetS status change, specifically in Portuguese adults.

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Section: Discussionmentioning

confidence: 99%

Structural Equation Modelling for Predicting the Relative Contribution of Each Component in the Metabolic Syndrome Status Change

Teixeira

Bragada

et al. 2022

IJERPH

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“…Since the identification of dietary nitrates as a source of NO, numerous clinical trials have been performed, which examined the effect of nitrate supplementation on SBP and DBP. In early clinical trials, nitrates were administered as inorganic salts or beetroot juice to healthy volunteers, whereas later trials explored combinations of concentrated beetroot powder, sodium nitrite, and various phytochemicals given to patients diagnosed with elevated BP [21][22][23][24][25]. In 2013, Siervo et al presented a meta-analysis of 16 early, randomized, placebo-controlled clinical trials.…”

Section: Discussionmentioning

confidence: 99%

“…More recent clinical trials on dietary supplements formulated with nitrate or nitrite decreased SBP and DBP in mostly prehypertensive subjects. A complex formulation by Berkeley Life®, consisting of encapsulated beetroot extract, thiamine nitrate, potassium nitrate, and ascorbic acid, showed a decrease of 6.3 mmHg in SBP and 4.7 mmHg in DBP when given daily to individuals with baseline BP of >120/80 mmHg for 12 weeks [ 25 ]. The source of NO from this formulation is primarily dependent on NO3- derived from potassium nitrate and to a lesser extent from thiamine mononitrate and the beet extract.…”

Section: Discussionmentioning

confidence: 99%

Effects of S-Allylcysteine-Rich Garlic Extract and Dietary Inorganic Nitrate Formula on Blood Pressure and Salivary Nitric Oxide: An Open-Label Clinical Trial Among Hypertensive Subjects

Houston,

Chen,

D'Adamo

et al. 2023

Cureus

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Introduction: The conversion of dietary inorganic nitrate (NO3-) to nitric oxide (NO) is a non-canonical pathway that plays an important role in NO biology, especially under pathological conditions. Inorganic NO3-supplementation is a proven method for controlling mild hypertension. Recent reports have suggested that another gaseous transmitter, hydrogen sulfide (H2S), influences NO biosynthesis and metabolism. Here, data are presented from an open-label clinical trial examining the effect of an encapsulated formulation (Vascanox® HP) that combines dietary sources of inorganic NO3-and S-allylcysteine (SAC), a source of H2S from garlic, on NO bioavailability and blood pressure in subjects experiencing elevated blood pressure or mild hypertension.Methods: An open-label clinical trial was conducted among patients with hypertension. Participants took Vascanox® for four weeks. Blood pressure was measured at baseline, two weeks, and four weeks. Salivary nitrite (NO2-), a surrogate of NO bioavailability, and NO3-were assessed prior to and two, six, and 24 hours after dosing on the first day of the study and prior to and two hours after dosing at subsequent study visits using saliva NO test strips. Changes in study outcomes over time were evaluated via analysis of variance (ANOVA) and paired t-tests.Results: Twelve participants completed the clinical trial. Vascanox® HP decreased systolic blood pressure by ~11 mmHg (p < 0.001) at two weeks and persisted beyond four weeks with daily supplementation. It also decreased the diastolic blood pressure of hypertensive subjects but not normotensive ones. The magnitude of the decrease was 11 mmHg (p < 0.01) at four weeks of study. Measurements of salivary concentrations of NO2-revealed high peak levels (743 uM) at two hours post-administration and a slow decay to elevated levels (348 uM) at 24 hours. NO2-salivary concentrations, a surrogate biomarker of NO bioavailability, remained above baseline for the duration of the study.Conclusions: Vascanox® HP was shown to be a safe, effective, quick-acting, and long-lasting dietary supplement for controlling mild hypertension.

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Bioactive profile, pharmacological attributes and potential application of Beta vulgaris

Bashir,

Tabassum,

Adnan

et al. 2024

Food Measure

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Effect of a plant-based bioequivalent inorganic nitrate (NO3−) complex with vitamins, antioxidants and phytophenol rich food extracts in hypertensive individuals - A randomized, double-blind, placebo-controlled study

Cited by 8 publications

References 49 publications

Structural Equation Modelling for Predicting the Relative Contribution of Each Component in the Metabolic Syndrome Status Change

Structural Equation Modelling for Predicting the Relative Contribution of Each Component in the Metabolic Syndrome Status Change

Effects of S-Allylcysteine-Rich Garlic Extract and Dietary Inorganic Nitrate Formula on Blood Pressure and Salivary Nitric Oxide: An Open-Label Clinical Trial Among Hypertensive Subjects

Bioactive profile, pharmacological attributes and potential application of Beta vulgaris

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