Effect of a PCB-based transformer oil on testicular steroidogenesis and xenobiotic-metabolizing enzymes

Andric, Nebojsa L.; Kostic, Tatjana S.; Zoric, Sonja N.; Stanić, Bojana; Andrić, Silvana A.; Kovačević, Radmila

doi:10.1016/j.reprotox.2005.12.002

Cited by 25 publications

(12 citation statements)

References 37 publications

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“…A low level of this steroid might be due to decreased activity of 20β-HSD, the enzyme responsible for the conversion of 17α-hydroxyprogesterone to 17α,20β-P (Nagahama et al, 1993). There is evidence showing that PCBs as well as other endocrine disrupting chemicals (EDCs) impair steroidogenesis through an influence on the activity of enzymes involved in the steroid biosynthesis cascade in vertebrates (Benninghoff and Thomas, 2005;Wójtowicz et al, 2005;Andric et al, 2006;Hatef et al, 2012). In our study, it is possible that Aroclor 1254 was able to influence gonadal steroidogenesis by acting directly on the gonads.…”

Section: Discussionmentioning

confidence: 99%

“…There is also evidence confirming changes in steroid hormone production (testosterone, progesterone, and estradiol) due to the direct action of PCBs on the activity of specific steroidogenic enzymes, such as 17β-HSD and P450 aromatase (Wójtowicz et al, 2005;Andric et al, 2006). Benninghoff and Thomas (2005) suggest the existence of a novel mechanism of endocrine disruption by PCBs that involves the alteration of calcium-dependent signalling pathways regulating steroidogenesis in fish.…”

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confidence: 99%

“…PCBs have been noted to influence testicular and ovarian steroidogenesis in pigs, cows, and rats (Wójtowicz et al, 2000(Wójtowicz et al, , 2005Andric et al, 2006;Kotwica et al, 2006). There is also evidence confirming changes in steroid hormone production (testosterone, progesterone, and estradiol) due to the direct action of PCBs on the activity of specific steroidogenic enzymes, such as 17β-HSD and P450 aromatase (Wójtowicz et al, 2005;Andric et al, 2006).…”

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confidence: 99%

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Effects of Aroclor 1254 on LH and 17,20β-P secretion in female Prussian carp (Carassius gibelio Bloch) in the spawning season

Socha¹,

Sokolowska-Mikolajczyk²,

Szczerbik³

et al. 2013

CZECH J ANIM SCI

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ABSTRACT:The effects of Aroclor 1254 on the secretion of luteinizing hormone (LH) and 17,20β-dihydroxy-4-pregnen-3-one (17,20β-P) in female Prussian carp (Carassius gibelio Bloch) at the time of their natural spawning were determined. Aroclor 1254 at doses of 0.01, 0.1, and 1 mg/kg body weight was dissolved in 500 ml of oil and was administered three times intraperitoneally or rectally to female Prussian carp every 24 h for three days. Blood samples were collected after 3 days of Aroclor 1254 administration to determine the LH and 17,20β-P concentrations using ELISA. At 6, 12, and 24 h after injection of gonadotropin-releasing hormone analogue (GnRH-A) blood samples were collected for stimulated LH secretion determination. Aroclor 1254 administered intraperitoneally (0.1 and 1 mg/kg) and rectally (0.01 and 1 mg/kg) significantly increased spontaneous LH secretion. In the case of GnRH-A-stimulated LH release, Aroclor 1254 (administered intraperitoneally only) at concentrations of 0.1 and 1 mg/kg significantly decreased gonadotropin release. The intraperitoneal injections of the lowest tested concentration of Aroclor 1254 also significantly decreased 17,20β-P secretion. The results show that Aroclor 1254 can affect the reproductive system of Prussian carp by changing the secretion of two very important hormones, LH and 17,20β-P, at the time of natural spawning.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Effects of Aroclor 1254 on LH and 17,20β-P secretion in female Prussian carp (Carassius gibelio Bloch) in the spawning season

Socha¹,

Sokolowska-Mikolajczyk²,

Szczerbik³

et al. 2013

CZECH J ANIM SCI

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“…There is a substantial evidence that in mammals, as well as in fish, polychlorinated biphenyls influence gonadal steroidogenesis (Yano and Matsuyama 1986, Wójtowicz et al 2000, Benninghoff and Thomas 2005, Gregoraszczuk et al 2005, Andric et al 2006. In fish, in addition to the observed disruptions in hormonal secretion at the HPG axis, exposure to PCBs mixtures suppresses ovarian follicle development, decreases ovarian growth, as well as decreases the quality of semen and eggs , Thomas and Doughty 2004, Coimbra and ReisHenriques 2007, Socha et al 2008a, Daouk et al 2011, Kraugerud et al 2012b.…”

Section: Introductionmentioning

confidence: 99%

The Effects of a Highly Chlorinated Biphenyl—Delor 106—on the in Vivo and in Vitro Luteinizing Hormone Secretion in Female Prussian Carp, <I>Carassius Gibelio</I> (Actinopterygii: Cypriniformes: Cyprinidae)

Socha¹,

Sokolowska-Mikolajczyk²,

Szczerbik³

et al. 2013

Acta Icth et Piscat

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“…Relying on years of high-quality research in the field of animal physiology, specifically in reproductive endocrinology e.g. [1][2][3][4][5][6][7][8][9], the activities of LECOTOX researchers were (and still are) focused on toxic impact of persistent organic pollutants (POPs) on biota with special emphasis on specific sublethal types of toxicity -endocrine disruption, reproductive toxicity, and "dioxin-like" toxicity [10][11][12][13][14][15][16]. Bio analyses based on molecular and cellular biomarkers of effects, such as cytochrome P450 (CYP) enzyme induction and parameters and markers of oxidative stress and early intoxication have been applied in assessment of freshwater ecosystems e.g.…”

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confidence: 99%

REP-LECOTOX: an example of FP 6 INCO project to strengthen ecotoxicological research in WBC (Western Balkan countries)

et al. 2011

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FP6 (2007FP6 ( -2009) presented a crucial milestone for LECOTOX, both in terms of overall research performance and its visibility and presentation to international scientific community. The project enabled upgrading and renewal of S&T equipment, hiring new young researchers to reinforce human resources and it facilitated extensive networking -via workshops, exchange of scientific personnel and trainings of young scientists in some of the finest research institutions in the EU in the field of environmental research: Helmholtz Centre for Environmental Research -UFZ, Leipzig, Germany; School of Bioscience, University of Birmingham, UK and RECETOX, Masaryk University, Brno, Czech Republic. The project enabled LECOTOX, focusing mainly on two research topics, i.e. endocrine disruption/ reproductive toxicity, and identification and characterisation of aquatic toxicity, to form a functional competitive research team ready for combining transcriptomics with the established conventional toxicity tests and traditional function-based biomarkers. LECOTOX became well-equipped and experienced research group confident enough to join any FP or otherwise funded ecotoxicological research project and network.

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Effect of a PCB-based transformer oil on testicular steroidogenesis and xenobiotic-metabolizing enzymes

Cited by 25 publications

References 37 publications

Effects of Aroclor 1254 on LH and 17,20β-P secretion in female Prussian carp (Carassius gibelio Bloch) in the spawning season

Effects of Aroclor 1254 on LH and 17,20β-P secretion in female Prussian carp (Carassius gibelio Bloch) in the spawning season

The Effects of a Highly Chlorinated Biphenyl—Delor 106—on the in Vivo and in Vitro Luteinizing Hormone Secretion in Female Prussian Carp, <I>Carassius Gibelio</I> (Actinopterygii: Cypriniformes: Cyprinidae)

REP-LECOTOX: an example of FP 6 INCO project to strengthen ecotoxicological research in WBC (Western Balkan countries)

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