Effect of a PAF Antagonist, BN52063 on Antigen-Induced Cutaneous Responses in Atopic Subjects

Roberts, NM; Page, Clive; Chung, Kian Fan; Barnes, P. J.

doi:10.1042/cs074064pb

Cited by 2 publications

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“…In man, WEB 2086 and BN 52063, a mixture of ginkgolide PAF receptor antagonists, blocked PAFinduced oedema in the skin of atopic and normal subjects [12,18,19]. Oral administration of BN 52063 also significantly inhibited the late phase of antigen-induced wheal formation in a group of 10 atopic volunteers and attenuated the early phase in 5 of the 10 subjects [13]. Thus, PAF appears to play a role in the antigen-induced oedema response of human atopic subjects as well as sweet itch horses.…”

Section: Discussionmentioning

confidence: 73%

“…In the skin of human atopic subjects intradermal administration of PAF, like antigen, caused local oedema and eosinophil accumulation [11,12]. Moreover, oral administration of a PAF receptor antagonist inhibited oedema produced by injection of antigen into the skin of atopic volunteers [13]. In contrast, intravenous administration of two different PAF receptor antagonists did not inhibit oedema induced by antigen in a guinea pig passive cutaneous anaphylaxis (PCA) model of type 1 hypersensitivity [14,15].…”

Section: Introductionmentioning

confidence: 97%

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Actions of PAF receptor antagonists in horses with the allergic skin disease sweet itch

1995

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Platelet activating factor (PAF) mimics the effects of Culicoides antigen by inducing oedema and inflammatory cell accumulation in the dermis of horses with the allergic skin disease, sweet itch. PAF could therefore contribute to antigen-induced inflammatory changes in these horses. We now report that intravenous administration of the PAF receptor antagonist WEB 2086 (3 mg kg-1), at a dose that inhibited the vascular and cellular responses to PAF in sweet itch horses, reduced Culicoides antigen-induced oedema at 1 h by 73% and at 8 h by 71% (p < 0.05). Neutrophil accumulation and eosinophil recruitment were not significantly reduced by WEB 2086 or a second hetrazepine PAF receptor antagonist WEB 2170 (0.1 mg kg-1). These findings suggest a key role for PAF in oedema formation, but not inflammatory cell accumulation, induced by Culicoides antigen in the skin of sweet itch horses.

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